Brain Protein "Rescues" Neurons From Atrophy
...development and of learning and memory, as well as clinical treatment of neurological disorders such as epilepsy." According to Lo and Katz, future research will aim at understanding in detail the complex machinery by which brain cells produce neurotrophins and translate the chemical signals they represent in...Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
...m amount a chicken could withstand without showing clinical signs-- a dose representing at least three times t...amage. Tests also suggested that the severity of clinical signs depends on howactive a particular blood enzyme is in removing the foreign chemicals fromthe bo......or. Conversely, not enough dopamine contributes to clinical depression.Although therapeutic drugs for schizophrenia block dopamine receptors, theyhave limited effectiveness and produce side effects in many patients. "Years of research by many investigators have helped determine thecellular components that re...Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...ringtheir mice with other animals that had similar clinical signs, the researchershypothesized the animals wer... The findings support preliminary results of human clinical trials beingconducted at Duke and other research institutions of an experimental treatmentfor rheuma...Genetic Alterations Linked To Cancer In Some Blood Samples
...s. These results must be confirmed in much larger clinical trials, Sidransky says. The technique used in this study was developed by Sidransky's team and first used to detect cancer cells in urine. The test uses a series of DNA markers to seek out geneticmutations specific to each patient's cancer. "We dec...New Software Provides Quick Analysis of ion-Channel Activity
...tay open too long or not long enough, resulting in clinical disorders where the muscles are either too weak or too excitable. By analyzing the currents that are produced by the ion channels that bind the transmitter, scientists have been able to tell which part of the channel operation is affected and sugges......ty will make it possible to use brain-mapping as a clinical tool in diagnosis and treatment of brain pathology." Using a technique known as functional MRI (fMRI), Cohen and his colleagues do "brain-mapping" experiments that produce high- resolution images showing what brain sites are active during different k...Prostate Cancer May Be Predicted 10 Years Before Diagnosis
...an predict prostate cancer up to four years before clinical diagnosis," says Dr. James L. Fozard, Associate Sc...prediction of prostatecancer up to 10 years before clinical diagnosis of prostate cancer. The NIA and Hopkins team measured free and total PSA levels on stored,...ORNL Mice Helping Researchers Isolate, Identify Causes Of Cancer
...formation has led to the discovery of the cause of clinical symptoms inhumans. Because of the genetic similarity between mice and humans, researchers hopeto gain a better understanding of the development of certain human cancers,to earlier diagnoses and to better treatment strategies. This research was funded...Blood Test Can Identify Some Children With Strep-Related Behavioral Disorders
...arch tool that may be a few years away fromregular clinical use, said Henrietta Leonard, M.D., the study's second author.But the findings suggest that a subset of children exist--those who may begenetically predisposed to involuntary actions of OCD and tics--whose suddenand acute onset is associated with stre...Prostate Cancer's Aggressiveness May Be Predicted Early By The Ratio Of Free To Total PSA
... will be needed before this finding can be used in clinical practice," says Dr. H. Ballentine Carter, a urologist at Johns Hopkins School of Medicine who worked on the study. Dr. Metter adds, "The next step is to conduct studies of a larger sample of men with prostate cancer to see if these findings are repe...Emory Researchers Advance Gene Therapy Studies For Metastatic Melanoma Treatment
...s coursing through the circulatory system." Most clinical gene therapy for melanoma now being conducted around the country treats patients systemically, and results have not been particularly promising. "We are experimenting not only with injecting the gene directly into the tumor," says Dr. Armstrong, "...Children With AD/HD Have Significant Functional Disabilities Related to Attention Deficit
...Lock, M.D., who presented the results. Lock is UB clinical assistant professor of pediatrics and associate medical director of the Robert Warner Rehabilitation Center at Children's Hospital of Buffalo. Lock said the results could have significant impact now because, as of this month, children diagnosed...Better Peroxidase Improves Disease Diagnosis
...e soybean peroxidase for horseradish peroxidase in clinical diagnostic tests. "I was lukewarm about the idea at first," says Morrow, "but when I tried it, I was converted. I think he's got something that's a nice improvement over current technology." In addition to its superior performance in medical and indu...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...in animal studies and is about to enter phase 1 clinical trials in humans. Dr. Giordano was the first to identify and clone the pRb-2/p130 gene and demonstrate that it could halt the growth of tumors. He has been studying the family of tumor-suppressor genes for nine years. "The...Gene Shears In Cutting Edge Anti-Aids Trial
..., Dr Leigh Farrell announced today. The Phase One clinical trial, conducted at St Vincent's Hospital, Sydney,...ed cells before it can invade healthy cells. The clinical trial uses a harmless virus as a "taxi" to insertthe ribozyme into the target CD4+ cells. The ribozy...Second Gene Responsible For Tuberous Sclerosis Complex Identified
...It is called a complex because of the widerange of clinical manifestations. Clinical signs may be subtle and, as aresult, TSC can go unrecognized or misdiagnosed for many years. Although insome individuals it may take considerable time before symptoms develop, TSC isknown primarily as a childhood disorder. ...New Gene May Intensify Breast Cancer Growth
...he researchers have also begun to design the first clinical studies using thegene as a marker to find out how ...nd differently totherapy, do they have a different clinical outcome, are their tumors different,do they develop at a different age or at a different rate" We do...Study: Device Prevents Epileptic Seizures, Doesn't Damage Hearts
...round the vagus nerve in the neck. After extensive clinical trials,the U.S. Food and Drug Administration approved the stimulator July 16.Cyberonics Inc. manufactures it. By studying the device's effect on the vagus nerve, the UNC-CH team wasable to show no changes in patients' heart rates, or cardiac ...... and guidelines for human-geneticsresearch and its clinical applications. While tests are available for many disordersand can provide information that was not available before, theycan raise new and troubling questions, said Zallen, a geneticistand science policy expert in Science and Technology Studies atVi...