Tag: "collagen" at biology news

Molecular motor implicated in tissue remodeling

... research team discovered that MMP-1 moves along a collagen filament with a net unidirectional motion. One-way... its energy by breaking the molecular bonds in the collagen filament it is attached to. "In fact," Goldberg says, "with our model, a whole new principle emerge...

Bone marrow cells routinely help with wound healing

...nd found only the green cells in the skin produced collagen type III, which is one of the two most abundant co...agens in skin. The native skin cells produced only collagen type I. Researchers do not know why bone marrow would produce collagen III, which is typically found...

Anticancer drug zebularine specifically targets tumor cells

...al human fibroblasts, which are cells that produce collagen fibers and retain an ability to differentiate and grow. The difference between tumor cells and normal fibroblasts is that the growth of tumor cells tends to continue unchecked. What the researchers found was that, in all seven cancer cell lines, trea...

Long-term heart damage may result from constant confrontation and defeat

...environment) induced myocardial fibrosis, coronary collagen deposition, increase in coronary wall-to-lumen ratio, and coronary collagen-to-vessel ratio. A New Study Most available animal studies focus on cardiac impact after the injection of drugs that mimic the nervous system. A new study ...

Sequential signals choreograph embryonic tubule formation

...ed Madin-Darby canine kidney (MDCK) cells grown in collagen gels and stimulated with HGF. This experimental protocol results in the formation of branching tubules that resemble the development of tubules in many organs in vivo and allows for examination of molecular events that occur during tubulogenesis. "We...

Obesity and hypertension: Two epidemics or one?

...ion, elevated advanced glycation end products, and collagen cross-linking may play a role. Two of the most common causes of chronic renal (kidney) failure, diabetes and hypertension, are closely associated with obesity. Other metabolic factors including hyperlipidemia and hyperglycemia may contribute to alt...

CSIRO research in greatest biotech show on earth

...Engineering novel materials for cartilage repair, collagen technologies, biopolymers. Bioprocessing and Functional Foods - production of high value chemicals for the food, pharmaceutical and other industries Bioinformatics sophisticated statistical analysis of complex data sets generated in biotech...

Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles

...ic cells and fibroblasts, a cell that produces the collagen fibers that make up connective tissue. The dendritic cells displayed signs of stimulation, which opens the question of whether this peptide delivery system could be used to create new vaccines or immune therapies. The paper will appear in the print e...

MGH research team grows long-lasting blood vessels

... of blood vessels. These cells were placed into a collagen gel and grown in culture for about a day. Then the gels were implanted into cranial windows, transparent compartments placed on the brains of mice. Similar gels containing only endothelial cells were also prepared and implanted. Within a few days b...

JCI table of contents, March 1 2004

...ficantly enhanced the production and deposition of collagen fibers associated with the fibrotic process. Finally, this fibrogenic activity could be blocked by neutralizing anti TGF-beta1 antibodies confirming that TGF-beta1 is directly involved in bone marrow fibrosis in HCL. The report also suggests that the...

Two-drug approach might shorten painful labor, reduce Caesarean sections

...at relaxin reduces the density and organization of collagen fibers, which may explain the softening effect on the cervix. However, little is known about the mechanisms whereby it promotes growth of the cervix. Sherwood and colleagues have found that relaxin dramatically increases the accumulation of cells wit...

JCI Table of Contents, January 15 2004

...urnal of Clinical Investigation, suggests that the collagen overproduction and deposition in the lung causing idiopathic pulmonary fibrosis may develop from cells derived from bone marrow stems cells, rather than parenchymal lung fibroblasts. The authors induced pulmonary fibrosis in mice that had been altere...

New roles for protein modifications in cell migration

...srupt components of extracellular matrices such as collagen and proteoglycans (which help to build skin and soft tissue), and their roles in development and differentiation are the focus of interest in many research labs. Nishiwakifs team analyzed a number of mutations that result in aberrant gonadal phenotyp...

Researchers uncover pathway that could lead to plant generation of human-like protein

...r called a macrophage activating factor, a type of collagen and a heat shock protein. They have done the work on three plants -- tobacco, arabidopsis and alfalfa. "What we discovered is that there is a very complex set of reactions that exist in plants and no one knows how it got there or what it is doing th...

UIC researchers create tissue-engineered joint from stem cells

...stic microscopic components: for bone, a matrix of collagen with deposits of calcium salts, and for cartilage, collagen and large amounts of substances called proteoglycans. Mao stressed that much additional work is nee...

JCI Table of Contents, November 3, 2003

...w York report that following T cell activation the collagen receptor very late antigen-1 (VLA-1) is stably exp...tion via NADPH oxidase activity. Ang II stimulated collagen deposition and the secretion of inflammatory cytokines, leading to fibrosis. These effects were atte...

SUCCESS 2002 Student Contest award ceremony

...late their most important physical functions (i.e. collagen synthesis, differentiation) in the ideal weightlessness conditions of the International Space Station. Understanding the molecular mechanisms of the reduced functionality of osteoblasts could lead to new treatments for bone mass loss due to long-term...

Swimming can contribute to rebuilding bone strength

...omposition of the bone (e.g., water content ratio, collagen formation) in addition to the bone mineral density....

Fears of second-hand smoke confirmed

...and proliferation and to alter fibroblast-mediated collagen gel contraction in vitro. Using a human lung fibroblast cell line as a model to study some of the harmful effects of cigarette smoke, the researchers found: Cigarette smoke is able to induce cellular oxidative stress and that the oxidation depends...

JCI table of contents, 16 June 2003

...******************* Streptococcal binding to host collagen aids colonization Acute rheumatic fever is a seri... binding the major extracellular matrix component, collagen type IV. This finding represents a novel colonization mechanism. TITLE: Rheumatic feverassociated St...

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