New Study Shows Steps Leading To Colon Cancer
...sort of mistake underlies essentially all cases of colon cancer and many melanomas, a form of skin cancer d...ce in which he discusses closely related papers on colon and skin cancer appearing in that journal. "Science and detective fiction share many features: a m...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
...al College, and co-discoverer of the human MSH2 colon cancer gene, thinks the answer lies with the X chromosome, one of two sex chromosomes responsible for sexual development. Somehow, he theorizes, the missing genes throw off normal cell proliferation and development. He believes that by ge...Finished Your Lunch? Now Eat The Wrapper
...peopleate far more starch, bowel cancers and other colon diseases were virtuallyunknown. Dr Topping says resistant starch may soon have another great benefit:researchers are studying ways to use it as a "taxi" to covey otherbeneficial substances into the lower bowel. For example chemicals or even bacteri...Plant-Based Therapies Examined For Colon Cancer Prevention
...rowths, called polyps, inthe mucosal lining of the colon and rectum, the last part of the digestivetract. ...women aged 18years and older who have a history of colon polyps. Participants may not smokeand should be healthy. People interested in enrolling as partici...Colon Cancer Linked To Genes, Not Lifestyle
...nary care-old monkeys often get colon cancer, Uno discovered. "As in humans, the incidence of colon cancer dramatically increases with aging," he said. Colon c...New Molecular Switch Is The Key That Unlocks DNA Repair
...ismatch repair genes go awry, the result may be colon cancer. Such genes are part of the intricate mo...el, who was a co-discoverer of the hMSH2 and hMLH1 colon cancer tumor suppressor genes, only two genes--MSH2 and MLH1--are altered frequently in Heredi...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...rt another phase 1 trial, using RNA extracted from colon cancercells. The Duke cancer vaccine harnesses two biological powerhouses: thepotency of rare immune cells, called dendritic cells, whose job it is seek outforeign tissue and alert the immune system, and RNA, the agent that transfersinformati...Rapid Progress Reported On New Class Of Anti-Cancer Drugs
...up to 90 percent of pancreatic cancers, half ofall colon cancers and a quarter of all lung cancers. ... inhibitors showed invivo activity against breast, colon and lung cancer cells in culture, he said. Ronald Doll, of Schering-Plough Research In...Researchers Identify A Gene That Causes Juvenile Polyposis
... a disorderthat causes the growth of polyps in the colon or upper gastrointestinal tract,has been identifie... a relatively rare disease. However, 75 percent of colon cancer caseshave chromosomal losses from this region of the genome," Howe says."Understanding this g......s. "Leftuntreated, FAP patients invariably develop colon cancer." He noted that arandomized, placebo-contro...dition, form hundreds tothousands of polyps in the colon and rectum, and face the inevitable developmentof colon cancer from these polyps if the colon is not...Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells
Aspirin's preventive effects on colon cancer may result from itsinfluence on the develop...oidal anti-inflammatory drugs (NSAIDs) helpprevent colon cancer by inhibiting COX-2, which they found to be elevated incolon cancer cells. However, t...Relatives Of People with Colorectal Polyps Face Increased Risk For Colorectal Cancer
...overed that close relatives ofindividuals who have colon polyps (non-cancerous growths, or adenomas) face a...results are positive. A family history ofpolyps or colon cancer can reflect genes that predispose to colorectal cancer,or shared dietary or other lifestyle h...A New Molecular Marker For Prostate Cancer
... shown topredict disease progression in breast and colon cancer. Researchers divided the 96 tumors into three groups, based on the percent oftumor cells in each sample expressing p27 protein. Fifty-three tumors had highlevels of the protein, with more than 50 percent of tumor cells expressing p27;31 tumor...NCI Awards Hopkins $3.8 Million For Cancer Genetics Network
... initial projects willfocus on breast, ovarian and colon cancers, malignancies for which there is aknown genetic predisposition. However, future studies of other familial cancersalso are planned. Such research projects will be enhanced by the establishmentof the network which will accelerate the research...Antisense Therapy Prevents Burkitt's Lymphoma In Mice
...oma, breast cancer, ovarian cancer, lung cancerand colon cancer. The next step, Dr. Wickstrom says, is to test the therapy in humans. "Myclinical colleagues here at Jefferson would like to test this therapy in a smallgroup of patients. We've asked the National Cancer Institute for assistance withth......ation was linked to anincreased risk of developing colon cancer. In that study, published in theSeptember 1997 issue of Nature Genetics, some of the individuals with coloncancer also had a family history of breast cancer. This led Dr. Offit's groupto question whether the APC mutation might appear more fr...Hopkins Researchers Discover Key Target In Molecular Pathway That Initiates Colon Cancer
In the latest of a series of discoveries about colon cancer genes, researchersat the Johns Hopkins Onco...PC and c-MYC, that conspiresto initiate almost all colon cancers. Their findings are reported in theSeptember 4, 1998, issue of SCIENCE. The APC tumor supp...Loss Of Tumor Suppressor Gene Triggers Colon Cancer
...r Vogelstein, who has studied the genetic basis of colon cancer fornearly 20 years, "this ends one chapter ...lyposis coli), and linked mutations inthat gene to colon cancer. Mutations in the APC gene were found in thehundreds of polyps that populate the colons of ...Cattle Diets Could Control E. Coli Danger
...pionic and butyric acidsaccumulate in the animal's colon -- a large fraction of "E. coli" produced arethe acid-resistant type. "Grain does not specifically promote the growth of "E. coli" O157:H7, but itincreases the chance that at least some "E. coli " could pass through thegastric stomach of humans," Rus...Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
...ishel, Rschoff and their colleagues examined human colon cancercell lines with defective mismatch repair ge...r (HNPCC). The scientists then treated the colon tumor cells with two drugs:aspirin and sulindac, which are both nonsteroidal anti-inflammatory drugs...