Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
...n importance. Here we havethe lungs synthesizing a compound and delivering it to tissue where it ismetabolized, just as oxygen is." In addition, the research shows that NO has a regulatory "allosteric"function that has not been described before, Stamler said. Allosteric regulationis when one molecul......d to mate, the females checked their heads for the compound and, finding none, curled their abdomens and rebuffed their advances. "Isn't it ironic that a compound with a misplaced reputation in human sexual behavior is actually used for a sexual purpose by insect...Researchers Use Hydrated Lime To Reduce Toxic Selenium Emissions
... this reactionhas been documented," Fan said. "The compound is thencaptured by the dry sorbent and can be disposed of with the flyash." The researchers found that the hydrated lime was most effectiveat 400 to 600 degrees Celsius, and able to "capture"up to five percent of its weight in selenium. At higher tem...Component In Soy Products May Be Substitute For Estrogen Treatment
...one-mineral density, providing evidence that a key compound in soy products-- isoflavones -- could be a substitute for estrogen treatment. The findings were presented Sept. 16 in Brussels, Belgium, by Universityof Illinois researchers attending the second International Symposium onThe Role of Soy in Preventi...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...an-Kettering Cancer Center have created apromising compound that recruits the body's immune system totarget and wipe out cancer cells in the liver. In a study withlaboratory rats, the majority of animals injected with thevaccine were cancer-free, while similar animals that did notreceive the vaccine typically...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...ochester's Cancer Center have created a promising compound that recruits the body's immune system to target a...y cancer cells that escaped the surgeon's knife. A compound that does this, such as the vaccine cocktail put together by Drs. Federoff and Fong, is known as an ......ential target for therapeutics," said Katze. "If a compound can be identified that inhibits or prevents the as...ion, interferon response could be restored. If the compound were administered in combination with interferon, it could potentially bring the virus under control...Project Shows Native Bacteria Can Destroy Widespread Pollutant In Groundwater
...ring petroleum product, causes them to produce the compound toluene monoxygenase that initiates the breakdown of TCE into carbon dioxide, water and chloride. Despite the success of the pilot study, there were questions that could only be answered by a full-scale test. There was concern, for example, that the ...Duke researchers find existing drugs can stop fungus that attacks AIDS patients
...did not suppressthe immune system. One of these, a compound called L-685,818, a close analog of the U.S. Food and Drug Administration-approveddrug FK506, proved toxic to the fungus, while sparing normal immune systemfunction. The Duke researchers are now testing the compound, produced bythe pharmaceutical co...Female Fireflies Lure Males For Defense Chemical
...nly tasted them. Because the fireflies' defensive compound was found to have a close chemical resemblance to ...lies -- unless they were artificially fed with the compound or were able to attract and eat Photinus fireflies. "To many of us, there's something intriguing and...Chemists Develop High-Throughput Method To Synthesize And Screen Novel Antibiotics
...Professor Richard Day, uses apatented intermediate compound (a Leuchs anhydride) for rapidsynthesis of novel antibiotics. It is coupled with a high-throughput method for screening the compounds' activity. Thecomplete process takes about two days. "We have over 1,000 novel beta lactams," said Day. "Most ofthem...Plant-Based Therapies Examined For Colon Cancer Prevention
...ed for centuries as anantiinflammatory agent. The compound is the pigment that gives the yellow colorto the seasoning curry, mustard and turmeric, the powdered form of the root ofCurcuma longa Linn. Curcumin is an approved additive for foods in the UnitedStates. Quercetin can be naturally found in most frui...New, Environmentally Friendly Technique For Separating Liquids Invented At UNC-CH
...the desiredcompound away from whatever undesirable compound it is mixed with, workers caneasily vent the harmless CO2 into the atmosphere or recycle it for further use.What remains is the product chemists are trying to isolate. Research published in the latest Nature describes how the team used itstec......rchers conducted experiments with theantisteroidal compound RU-486, perhaps better known for its use in Europe as anabortion-inducing agent, to see if that drug could counter the effects of Vpr.They added Vpr to populations of cultured lymphocytes in the laboratory,documented its impact, and then added RU-486...Scientists Find New Trigger For Nerve Cell Death
...aside effect, Yu blocked potassium channels with a compound called TEA(tetraethylammonium). The potassium channel blocker reduced the number of cellsthat died after serum withdrawal, suggesting that potassium loss is indeed atrigger for apoptosis. Reducing potassium loss by increasing the amount of po...First Selenium-Based Orally-Active Antihypertensive May Lead To New Family Of Therapeutic Agents
...s metabolized. Levels of the hydroxylatedselenium compound in brain tissue were significantly lower than in o... analytical techniques developed for studying this compound toexplore other aspects of selenium biochemistry. "We'd like to explore other possible applications...Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme
...by forming a short-living Ni-CH3, metal-organic compound rarely found in biological systems. The structure was solved in two different enzyme states which ressemble the coenzyme binding before and after reduction. When comparing the two enzyme states coenzyme M moves more about 4 E and thus pro...Harbor Branch Oceanographic Institution Receives $1.1 Million Grant From National Cancer Institute
...9, 1997. Discodermolide is a promising anti-cancer compound derived from the marine sponge, Discodermia dissol... Harbor Branch team and collaborators revealed the compound to be a potent anti-tumor agent with a mechanism of action similar to that of the clinical anti-canc...Green Tea Ingredient Can Kill Cancer Cells
...ituent of the polyphenols found in green tea. This compound has been shown in previous studies from CWRU and e...his happens, said Mukhtar. "It is likely that this compound conveys a message to cancer cells through a highly ordered and well-regulated signal transduction pa......s. They are N-isopentyl-2-phenylethylamine, a key compound never beforeidentified from nature; anabaseine (3,4,5,6-tetrahydro-2,3'-bipyridine );anabasine [3-(2-piperidinyl)pyridine]; and a fourth chemical never before foundin ants, 2,3'-bipyridyl. Further studies with the ants showed that the four chemical...