Dartmouth engineers closer to mass-producing therapeutic proteins
Hanover, N.H. -- Dartmouth engineers are one step closer to mass-producing therapeutic proteins desperately needed by today's pharmaceutical industry. ... ...Reported in today's early online edition of the Proceedings of the National Academy Of Sciences, the researchers have achieved a major milestone in their efforts to effectively produce human therapeutics using a yeast-based protein expressio...Dartmouth Medical School awarded $9 million grant for genomics research
HANOVER, NH Dartmouth Medical School will lead a $9 million National Institutes of Health grant to direct a collaboration in functional genomics that will be one of the most comprehensive to date within the group of organisms studied. The award to DMS's department of genetics from National Institute of General Medical Sciences will be used primarily to analyze the roles and functions of genes i...Dartmouth study advances prion disease research
Hanover, NH Adding to the paradox of prion diseases, Dartmouth Medical School researchers have discovered that RNA plays a role in converting a normal prion protein into a mutant that leads to mad cow disease and other fatal brain illnesses. ... ...Their study, reported in the Oct. 16 issue of Nature, provides important clues to understanding the role of prions, unorthodox infectious agents who...Dartmouth bioengineers develop humanized yeast
Hanover, N.H. Bioengineers at Dartmouth have genetically engineered yeast to produce humanized therapeutic proteins to address the manufacturing crunch currently confronting the biopharmaceutical industry. Reported in this week's issue of , the researchers have re-engineered the yeast P. pastoris to secrete a complex human glycoprotein--a process offering significant advantages over current pro...Dartmouth researchers find two circadian clocks in the same plant tissue
HANOVER, N.H. Dartmouth researchers have found evidence of two circadian clocks working within the same tissue of the plant Arabidopsis thaliana, a flowering plant often used in genetic studies. Their results suggest that plants can integrate information from at least two environmental signals, light and temperature, which is important in order to respond to seasonal changes. ...... The study, p...Arsenic in drinking water may be linked to cancer Dartmouth study finds
Hanover, NH Exposure to small amounts of arsenic in drinking water may inhibit expression of genes involved in a critical housekeeping function that enables cells to repair damaged DNA, Dartmouth Medical School researchers find. The process, known as DNA repair, is considered a major biological defense in the body's ability to fight cancer. ...... The study, published in the April issue the In...Dartmouth researchers put recycling in perspective
HANOVER, N.H. Three Dartmouth researchers have found that resisting the temptation to buy an SUV can benefit the environment much more than recycling. They say that while recycling of some materials does contribute to overall environmental improvement, other personal decisions, such as what kind of car you drive, have a much greater environmental impact....... Andrew J. Friedland, professor and...Dartmouth Medical School geneticists discover new role for antisense RNA
Hanover, NH Dartmouth Medical School geneticists studying the biological clock have opened yet another window into the role of an unusual form of RNA known as antisense that blocks the messages of protein-encoding genes. ......They found that antisense RNA appears to regulate core timing genes in the circadaian clock that drives the 24-hour light-dark cycle of Neurospora, a model organism better...Dartmouth researchers identify multi-tasking circadian protein
HANOVER, N.H. -- Dartmouth Medical School geneticists have found a molecular shortcut from light reception to gene activation in their work to understand biological clocks. Their research has revealed that the protein called White Collar-1 does double duty: it perceives light and then, in response to light, directly turns on a key gene called frequency, which is a central component of the clock.....New way found to see light through novel protein identified by Dartmouth geneticists
Hanover, NH--Dartmouth Medical School geneticists have discovered a new class of proteins that see light, revealing a previously unknown system for how light works. ...... The novel photoreceptors are part of the gears that drive biological clocks, the cellular timekeepers of the circadian rhythm, which paces life's daily ebb and flow in a 24-hour light-dark cycle. Their identification also open...Cancer killing gene found by Dartmouth researchers
Cancer Killing Gene Found by Dartmouth Researchers...Hanover, NH - Dartmouth Medical School cancer researchers have identified a gene that triggers the death of leukemia cells, opening a novel target for anti-cancer drugs. ...This new genetic switch, reported in the March 19 issue of the Proceedings of the National Academy of Sciences, turns on a program to destroy certain leukemic cells and pos...Dartmouth biologists say algae might be missing mercury link in aquatic food chain
HANOVER, N.H. A team of Dartmouth researchers is one step closer to understanding how toxic metals, specifically methylmercury, move through the aquatic food chain. Their results, to be published in the April 2, 2002, issue of the Proceedings of the National Academy of Sciences (available online March 19), suggest that there is a link between the amount of algae in the water and the amount of me...Dartmouth researchers expose weakness of common parasite
Hanover, NH Dartmouth Medical School geneticists in the Department of Microbiology and Immunology have discovered how to weaken a common human parasite to prevent disease in an animal model after infection by the normal parasite. The work, reported in the February 21 issue of Nature, opens new avenues for the development of vaccines and other treatments for diseases such as toxoplasmosis caused...Seat of cellular bus system for protein passengers found by Dartmouth Medical School researchers
Hanover, NH For some proteins made deep within a cell, those that work elsewhere in the body have a complex journey aboard carrier vessels with many possible stops before they exit the cell and continue through the blood to reach their destination. Now Dartmouth Medical School biochemists have discovered a key receptor for sorting which proteins stay and which leave, documenting for the first t...Geneticists at Dartmouth Medical School have discovered a new family of unusually small genes that act in the finely tuned yet remarkably versatile orchestration of development and behavior, adding still another dimension to the diversity and complexity of the cell. ... ...Unlike most genes, these new-found ones do not encode for proteins, but rather produce tiny regulatory RNAs, dubbed "microRNA...Dartmouth researcher goes to Cape Cod to study cell division
...Hanover, NH Like many who visit Cape Cod in the summer, Roger Sloboda, Ira Allen Eastman Professor of Biology at Dartmouth College, goes for the clams. Not the fried ones, however. He prefers his clams ripe with eggs. ...Slobodas been making this trip since 1980 to study how cells divide, a process called mitosis. With support from the Whiting Foundation, he will embark on his annual journe...What makes cells tick detailed by Dartmouth researchers
...Hanover, NH -- Dartmouth Medical School geneticists have clarified the picture of the way living things maintain robust and stable internal clocks to safeguard the timing of daily activities. ... ...Internal clocks are ubiquitous. In humans they cue circadian rhythms, the ...24-hour cycle that paces life's ebb and flow, from when we wake up to when we go to sleep. They are linked to jet lag,...Dartmouth research offers clues to new anti-microbial treatments
...HANOVER, NH--The race to stay ahead of bacteria that develop resistance to frequently used antibiotics may be paying off. Dartmouth Medical School (DMS) researchers have discovered how to block a pathway many bacteria use to infect organisms. ... ...Dr. Ronald Taylor, professor of microbiology, and Christian LaPointe, a graduate student, report a way to inhibit the enzyme that many types of...Dartmouth Medical School Researchers Discover Heavy Metal Contamination In Northern Mexico
...LEBANON, N.H. -- Dartmouth Medical School (DMS) researchers have discovered...industrial pollution sites in northern Mexico that have higher than ever before...reported levels of heavy metal contamination. Smelters in Torren and Chihuahua...constitute a serious environmental threat to people living near these...industries, according to a report in the April issue of Environmental Health...Pe...