Heart gene yields insights into evolution, disease risk
...rch, and that of other evolutionary biologists, is directing us toward a new, more nuanced view of genetic variants which is that, in fact, variation is part of what it means to be human. And that this variation is not just harmful mutation but really a process that contributes to the health of populations." S...Women who have donated eggs sought for national study
...professor of psychology and women's studies who is directing the research. "There have been many studies on the efficacy of reproduction using donated eggs and on the health of children born from this procedure, but women who donated eggs have been generally ignored. No one knows what has happened physically...Study explains spatial orientation differences between sexes
...ually is, they tend to pull up to compensate, thus directing the plane away from the ground." Tremblay says his finding has good potential for practical applications such as designing gender-specific training for extreme situations such as piloting and space flight. "It's important to identify how men and wo...Casanova or caveman: Scientists isolate nerve cells that choreograph male fly's courtship behavior
...hat control sexuality in flies also play a role in directing human sexuality? "If you look at the basics of fly behavior, you find an innate ability to recognize somebody who is the right species and is the right sex," Baker said. "You tap them and get their attention, you play them a love song and so on. So t...K-State researchers share $1 million grant to study insect pests
...ne mutations and identifying regions important for directing patterns of gene activity," Brown said. The study has potential to form the basis of new strategies of insect control, as well as important advances in understanding insect genetics and development, Brown said. The K-State research team recently won ...Gene at root of urban air pollution's lung effects
...ne, he added. The new study expands TLR4's role in directing the lung's response to environmental exposures by highlighting its potential importance in exacerbation of asthma following ozone inhalation. The researchers found that ozone levels comparable to those experienced during consecutive red alert days --...New insight into how tumors resist radiation
...results indicate that HIF-1 acts as a major factor directing resistance of tumor vasculature to radiation therapy. According to Dr. Dewhirst, "We believe that by understanding how this protective response is activated, we can discover an effective means of inhibiting it. This work takes a major step toward ac...Researchers string together players in pesticide resistance orchestra
...y identify a 'conductor' gene that is critical for directing the biochemical processes that allow insects to detoxify pesticides," Pittendrigh said. "A gene or genes that may be critical for resistance, in turn, may become targets, enabling us to develop compounds to control pesticide-resistant insects." The s...Betty Ann Forbes wins 2004 ASM Founders Award
...al accomplishment. Well known for her expertise in directing large-volume clinical microbiology and diagnostic virology laboratories, Forbes maintains highly productive research and publication programs, focusing most recently on methods of detecting Mycobacterium tuberculosis and other pathogens. She is an aw...Malignant breast cancer cells to revert to normal with manipulation
...lling the nucleus of the cells what to do and thus directing gene expression in conjunction with these other factors. She had chosen the breast to study the critical role of the ECM in normal breast tissue, a model she had selected because it continues to change throughout life of women in puberty, pregnancy, ...Chemical that turns mouse stem cells into heart muscles discovered by Scripps researchers
...r studies. Cardiogenol C proved to be effective at directing embryonic stem cells into cardiomyocytes. Using Cardiogenol C, the scientists report that they could selectively induce more than half of the stem cells in their tests to differentiate into cardiac muscle cells. Existing methods for making heart musc...Studies suggest brain injury results from developmental exposure to alcohol, anesthesia, and lead
...matically activates a signal within the nerve cell directing it to commit suicide, a form of cell death known as "apoptosis." Olney noted that the apoptosis mechanism operates only during synaptogenesis, a developmental period "when nerve cells are growing rapidly and forming synaptic contacts required for be...Small-molecule inhibitors of anthrax lethal factor identified
...ilt. This pharmacophore will serve as a basis for directing future efforts to develop LF inhibitors with enhanced potency. "These studies have provided us with a road map to the rational design of more potent, highly selective lethal factor inhibitors," said lead author Sina Bavari of USAMRIID. "I believe ...Small-molecule inhibitors of botulinum neurotoxin identified
...ilt. This pharmacophore will serve as a basis for directing future efforts to develop BoNT/A LC inhibitors with enhanced potency. Testing in cell culture will be followed by animal modeling once the most promising candidates have been identified. Study collaborators were Sina Bavari, James J. Schmidt, and Ro...Michigan receives NCRR grant for tomorrow's proteomics technology
...e as they age. Proteins also serve as traffic cops directing complex biochemical signaling pathways in the body." Detecting trace amounts of a protein, which may exist in cells only for fractions of a second, requires extremely sensitive and expensive equipment to rapidly separate, analyze and identify all pro...White House awards National Medal of Science to Rockefeller University's James Darnell
...al and transfer RNA, molecules that assist mRNA in directing protein formation, showed that both these molecules are chemically "processed" -- chemical groups are added after synthesis and a long initial product is cut into usable pieces -- before their use in the cell's cytoplasm, the component of the cell th...Fourteen Grand Challenges in Global Health announced
... global health and direct funds to solve them. By directing substantial and carefully targeted resources toward key health-related research questions pertinent to developing countries, the Grand Challenges initiative is intended to attract talented investigators to address these issues and significantly accel...Soldier or worker what do the genes say?
... also discovered two genes that may be involved in directing termite development. These genes are related to two genes, called bric-a-brac and bicaudal, which regulate patterning in the fruit fly, Drosophila. Bric-a-brac works by inhibiting the expression of other genes. Increasing the expression of such a gen...Splitting hairs: GATA-3 function in hair follicle development
...tem, posited GATA-3 as an attractive candidate for directing epidermal stem cells to become IRS cells. To investigate the precise role of GATA-3 in hair follicle morphogenesis, Dr. Fuchs and colleagues turned to a strain of GATA-3-deficient mice to observe what defects, if any, appeared in these mice. Howeve...Main regulator of membrane trafficking not what researchers once thought, scientists discover
... Golgi can't function." PI4P acts as a zip code by directing proteins to the Golgi. An understanding of this system gives researchers insight into membrane trafficking, a vital process for cell survival. "If the Golgi does not have PI4P it can't perform vital functions necessary for cell survival," Dr. Yin sai...