Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
...ne. Because topoisomerase II is required during cell division, cancer cells, which divide wildly, are more sensitive to drugs that target topoisomerases than normal, more slowly dividing cells, Dr. Wang said. Part of the power of drugs that target topoisomerases is ...Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...no acid glutamine will be inserted intothe protein during its translation from genetic information to protein inthe brain cell. The greater the number of CAG repeats in the gene, the moreglutamines will be added, resulting in a structurally different proteinthat binds strongly to a particular energy enzyme....Researchers Pinpoint Site For Petit Mal Seizures In Brain
... hundreds of seconds-long lapses of consciousness, during which they stare blankly and may blink rapidly or sway before recovering. "Absence seizures usually take hold at a critical period in a child's initial education, and may be interpreted as a learning disability or isolate them from other children," ...Duke Geologists Explore Alternative Way To Measure Ice Age Sea Bottom Temperatures
...uct how bottom sea water temperatures have changed during and between past ice ages. In an article published...otopic record of its composition, those that lived during glacial times should have higher ratios of oxygen 18 than those that didn't. Foraminifera shells als...... that radioisotopes can migrate in and out of bone during the fossilization process, affecting the accuracy of dating. To double-check his data, Ku compared his mass spectrographic age determinations with results obtained from an alternate method - one using the isotopes Proactinium-231/Uranium 235. Though ...Southern Pine Beetle Reaching Outbreak Levels In North Florida
...ing -- of an entire community. Using this approach during anoutbreak in Gainesville in 1994 saved thousands ...eetles dine only on stressed or damaged pines, but during outbreaks theyattack healthy trees. Females may live a month and lay 160 eggs, allowinginfestations ...Nutrition Study Reshapes Strategies For Athletes
... may eventually reshape strategies for nourishment during competition. Seven of the top eight spots on the ...success, said Houtkooper, is replacing fluids lost during practice andcompetition. She adds that this is especially critical in the hot and sultryenvirons of ...Water Recycling Project Tested in Turkey Plant
...e shown that direct applicationof ozone to poultry during immersion chilling can improve the microbiological...ty of the products and can extend their shelf life during refrigeratedstorage. The Food and Drug Administration has not approved direct application ofozone t...Bark Beetle Infestation Spurs Multifaceted Study
...overed in 1859, supplied silver to theUnion troops during the Civil War. Working in the mines, building the roadsand cutting the wood were a conglomerate of immigrants. Included among theseworkers were large numbers of Chinese laborers. "The archaeologists don't want to disturb the archaeological sitesor ...Hawaiian Whales Show 'No Overt Response' To Sounds Of ATOC Simulation
...ired to monitor marine mammal behavior before and during the ATOC experiment, previewed the low-frequency s... observers charted swimming courses of whale pods during sound transmission and during no-sound transmission periods. To ensure scientific objectivity, obs...Salvage Gene Is At The Root Of Many Mutations
...rase enzymes that usually zipalong a strand of DNA during replication. If a cell is unable to replicate its DNA, it will eventually die. Cells usually avoid this fate -- as well as mutations -- by accurately repairing abasic sites in a variety of ways.But very rarely these cellular efforts at quality ...Low-Protein Diet May Reverse Kidney Disease
...of amino acids. The disorder gradually disappeared during the next three to 15 months in five participants, who started the study before kidney failure became severe, the results show. Four of the five people have resumed normal or nearly normal diets and have remained in remission or near remission for six...Ocean Sediments Contain Record of Past Vegetation Fires in Africa
...d shows much more past burning, at least in Africa during the Pleistocene era, than researchers expected. National Science Foundation (NSF)-funded marine geologists David Verardo and William Ruddiman of the University of Virginia in Charlottesville have found in their research on ocean sediments the...Environmental Reform: The Next Generation Project
...e findings of 14 separate research teams that met during the past year on topics ranging from land-use issu...tributing to the debate about environmental reform during this fall's state and federal election campaigns. The full report will be published as a book early...Study Shows Songbirds Switch From Bugs To Berries To Fuel Fall Migration
... that North American migrating birdsconsumed fruit during autumn, but the extent and importance of that shif...any of these migrant birds behave very differently during migrationcompared to the summer breeding season in our forests and backyards where theiractions and ...Duke Ecologist Says Logging Is Creating 'Mahogany Deserts'
...mahogany ecology since first exploring the subject during 1987-92for her doctoral research at the Yale School of Forestry and EnvironmentalStudies. Searching the scant available publications,most dating from several decades earlier, she learned that the only truemahogany species (Swietenia macrophylla) no......ght into what elements of the circuit are modified during learning." The research was funded by the Whitehall Foundation, a private philanthropy that funds biomedical research with an emphasis on neurobehavioral studies....Discovery Of Cell Sites May Shed Light On How Bodily Systems Interact
...), a molecule produced by the body's immune system during a bacterialinfection, on the somatotrope cells in the pars anterior (outside sections)of the pituitary gland. The research, funded by the National Institutesof Health, was done using monoclonal antibodies as a stain to zero in onthe morphology of cel...Researchers Identify A New Cellular Structure: The "Dumposome"
...ng extra DNA." Dumposomes appear only briefly during the life cycle of Tetrahymena. Over a five-hour period during reproduction,molecules of a structural protein known as Pdd1p coalesce to form about a dozen circula...Newly Discovered Gene Halts Cell Division and May Have Cancer Link
...the thread-like fibers that pull chromosomes apart during cell division. After the researchers treated the breast tumor cell line with nocodazole, the cells continued to undergo cell division, which suggests the cells may be defective in the checkpoint. When the investigators looked further, they confirmed...