JCI Table of Contents, September 15, 2003
...hypertrophy, including class II HDACs, this report elucidates a novel growth-suppressing transcriptional pathway in cardiac muscle that opposes hypertrophic growth. In an accompanying commentary, Yasuo Hamamori and Michael Schneider from Baylor College of Medicine in Houston, Texas, further discuss the roles of...New method for 'visualizing' proteins
...s membranes and proteins. Basically, the technique elucidates how molecules move, react and interact with one another. The protein studied for the JACS report, T4 Lysozyme, is one of the proteins of a bacteriophage, or virus, that is parasitic within a bacterium. The protein degrades the bacterial cell wall ...Cardiovascular system holds a key to circadian clock
...cology and author ofthe study. "However, this work elucidates a molecular mechanism which permits a refinement of such chronopharmacology. Resetting the clock might have obvious application in the treatment of jet lag, but could also combine with existing knowledge to adjust circadian variability in drug respon......how associated with p53 activation. The new study elucidates the mechanism underlying P53 activation induced by DNA damage. "We found that the addition of the phosphate inhibits the export of p53 to the cytoplasm. We found a small sequence or small peptide in p53 that's required for p53 to be exported out. An...