Tag: "embryonic" at biology news
New Study Shows Steps Leading To Colon Cancer
...fied a key signaling mechanism required for normal embryonic
development. When inappropriately activated, studi... other words, turns genes on and off." In normal embryonic
development, by switching genes on and off, the protein tells cells which tissues they should make a...
Scientists Bridge Gap In Cell Communication
... if disrupted, can result in cancer and defects in embryonic
development. By revealing the terminus of the pathway by which cells send and receive messages, the find promises a rational basis for the future treatment of some diseases and, more immediately, gives science a new grasp of a process that t...
Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
...Y chromosome; women carry two Xs. During normal embryonic
development, certain genes of one of the X chromosomes may be turned off, a process called X-inactivation. Normally, there is some damage to the X and other chromosomes when cells duplicate and go through a "cell cycle." Cells have an ...
Doublecortin : A Novel Gene Involved In Cortical Development
...n Cell (January 9th 1998). In the early phases of embryonic
development, the cerebral cortex is formed bythe migration of successive waves of neurons. It is well established thatdefective neuronal migration can lead to severe cortical malformations, but thefactors involved in this phenomenon are poorly unders...
At Life's Most Sensitive Stage, Embryos Cope With Stress
...t how animals and plants cope with stress in their embryonic
stages. "We know surprisingly little at the cellul...1 DNA. The damage can cause mutations and can kill embryonic
cells, butthe embryo has a well-developed rescue mechanism, based on the work of a DNArepair enzyme ...
Cancer Cells Self-Destruct When "Sweet Tooth" Is Thwarted
... Ph.D., apostdoctoral fellow, Dang and others gave embryonic
mouse cells an unusuallyactive form of a gene known as c-Myc. Many cancer cells overuse this gene, mass-producing itsprotein to start chain reactions that help them switch from using oxygen for energy production tousing glucose. "When we bathe...
New Clue To apoE Function
...ed themwith neurons from the hippocampus of normal embryonic
mice, mimicking thecommunity of astrocytes and neurons that exists in the brain. The hippocampus isa seahorse-shaped structure associated with memory and learning, functions thatare compromised in Alzheimer's disease, where connections between nerve ...
Precursors To Red Blood Cells Form Earlier Than Previously Thought
...sors firstarise. "We wanted to know where and when embryonic
cells becomecommitted to blood cell fates, if blood cell precursors originatein the embryo or in the yolk sac, and at what point they show upin the body of the embryo," said Jim Palis, M.D., associateprofessor of pediatrics and the team's lead resear...
Max Planck Scientists Report Molecular Details On The Interaction Of The Stress Hormone Corticotropin-Releasing Factor (CRF) And Its Receptor
...ersa. These constructs were transfected into human embryonic
kidney (HEK) cells. The biological activity was tested by monitoring the production of the second messenger cAMP by the transfected cells in response to increasing concentrations of various CRF analogs. The affi...
Fetal Lead Exposure May Reduce Immunity
...cting parallel studies on early lead exposure with embryonic
chickens as animal models, but have no plans to extend the studies at the university to humans. But humans subjects, they say, would not be hard to find. "Unfortunately, pregnant women even in this country are exposed to these levels of lead throu...
Master Molecule Forms Brains In Frogs And Elbows In Mice
...pping a gene of interest out of the chromosomes of embryonic
mouse cells growing in a petri dish. The altered, "knockout" cells are then introduced into a recipient mouse, ultimately permitting researchers to breed colonies of mice "free" of the particular gene of study and then to observe how the mice fare wi...
Gene Linked To Glaucoma, Hydrocephalus, And Other Birth Defects
...Vanderbilt were workingwith genes important in the embryonic
development of flies. They were searchingfor corresponding genes in mice, which, in turn, offer a good model for studyinggenes in humans. They had zeroed in on a fly gene called forkhead, which whenmutated results in larvae whose heads do not develop...
Who Needs Flowers? Transgenic Plants Sprout Embryos On Leaves
...af surfaces sprouted tinyclusters of glove-shaped, embryonic
tissue. And some ofthose embryos, while still attached to the leaf surfaces,even grew roots. The new research, described in the June 26 issue of thejournal Cell, was the work of researchers in the laboratoryof UC Davis plant biologist John Harada an...
Novel Liver Steroid Slows Brain Tumor Growth
...vessel formation without damaging healthy cells or embryonic
development." Named for the shark genus Squalus, squalamine was discovered in 1992 byscientists who founded Magainin Pharmaceuticals, which processes the chemicaland funded the Hopkins studies. Squalamine is the first of a new class ofnatura...
Cultured Neural Stem Cells Reduce Symptoms In Model Of Parkinsons Disease
...eases by replacingdamaged cells with stem cells -- embryonic
cells from which all other kinds ofcells develop. ...educing the ethical concernsassociated with use of embryonic
tissue. The ability to grow neural stem cellsin the laboratory also provides an excellent opportuni...
First Reproducible Cloning Of Mammals From Adult Cells Reported In Nature
...cy of reproducibility and,when used in genetic and embryonic
development studies, will shed new lighton the cel...ass in preparation to form the first tissues of an embryonic
mouse. "We discovered that a relatively high proportion of the oocytesdeveloped into blastocysts an...
Defects In Embryonic Development In Lunatic Fringe Knockout Mice
...ckson Laboratory has confirmed animportant role in embryonic
development for the Lunatic fringe gene, part of acell communication mechanism known as the Notch signaling pathway that iscritical to the normal implementation of the body "blueprint" in mammals andother organisms. The findings are reported ...
Mechanism Discovered For Determining Early Vertebrate Body Plan: New Zebrafish Mutants Afford Deeper Look Into Embryonic Patterning
...e dorsoventral -- back to abdomen --arrangement of embryonic
tissues, a process called patterning. These genes guide embryonic
cells to become the belly or the back of thedeveloping fish, with mutations resulting in abnormally ...
Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
...ng tissue remodeling, immune system regulation and embryonic
development. Abnormal activation of apoptosis, how... that deletion of Caspase-9 does notinterfere with embryonic
development of other non-neuronal tissues," said Dr.Keisuke Kuida, Staff Investigator at Vertex and ...
Whitehead Study Establishes Role Of DNA Methylation In The Stability Of DNA,
Suggests Possible Role Of Undermethylation In Cancer
...e carrying thismutation die in the womb. However, embryonic
cells carrying the mutation cansurvive and grow in... The Whitehead researchers found that these embryonic
cells have a 6-10times higher mutation rate than normal, which suggests that there may be acausal r...
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