Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...us Corp. in Concord, Calif., employs a genetically engineered listeria bacteria based on a strain created by coa...als. Cerus ultimately hopes to use the genetically engineered listeria vaccine to target cancers such as pancreatic and ovarian cancer, and possibly leukemia and ...No role for simian virus 40 in human pleural mesotheliomas
... in the tissue samples but from SV40 DNA fragments engineered into common laboratory plasmid vectors used in molecular biology research. This source of SV40 DNA fragments may be unrecognized, leading to misinterpretation of assay results as indicating the presence of genuine SV40 in human tumors. Their finding...'Smart antibiotics' may result from UCLA research
...or treating bacterial infections using genetically engineered phages that will efficiently overcome bacterial resistance." Bacteriophages evolve rapidly and are a "treasure-trove of fascinating biological mechanisms," Miller said. His research team studied a bacteriophage that was able to change to recognize...Scientists find nanowires capable of detecting individual viruses
...ect common strains as well as variants genetically engineered by would-be bioterrorists. By making an array sensitive to numerous domains of a given virus, the chances of even a modified virus escaping detection would be very low. In a clinical setting, the extreme sensitivity of nanowire arrays means they coul...Microbes eat their way to better concrete
... Bang and Ramakrishnan plan to develop genetically engineered microorganisms that can produce excess amounts of organic and inorganic biosealant. "This microbial sealant is a smart material that is environmentally safer and economically more feasible than the currently available synthetic sealing materials," Ba...Scientists discover potential new way to control drug-resistant bacteria
...his discovery could lead to the use of genetically engineered phages to treat bacterial infections that have become resistant to antibiotics. "This serendipitous finding underscores the importance of basic research," says Anthony S. Fauci, M.D., director of NIAID. "With our increased understanding of how b...A novel, safer strategy for regulating gene expression
...ssible to develop a gene therapy whereby cells are engineered to secrete insulin in response to a rise in glucose. Such 'biological sensing' could have a wide range of applications." Current methods of gene regulation usually involve a complicated three-part system that requires a "promoter" (a DNA sequence nea...DuPont introduces in-home personal protection from dangers of hurricanes
... storm shelter made with DuPont TM Kevlar that is engineered to help provide residents protection from the dang...ries of tests conducted by an independent lab, the engineered panels built into the room were able to deflect a 12-foot, 15-pound two-by-four piece of wood shot o...Joslin researchers clarify mechanisms for beta-cell formation
...s compensatory growth in two different genetically engineered animal models of insulin resistance called IR/IRS-1 mice and LIRKO mice. Dr. Kahn is the Mary K. Iacocca Professor of Medicine at Harvard Medical School. The results of immunohistochemical staining suggest that these new beta cells are not derived...AACR applauds NCI initiative on nanotechnology
...eractions of cellular and molecular components and engineered materials typically clusters of atoms, molecules and molecular fragments at the most elemental level of biology. Such nanoscale objects can be useful by themselves or as part of larger devices containing multiple nanoscale objects. The new effort i...Can an old gene learn new tricks?
...e researchers found that when mice are genetically engineered to lack Hmx2 and Hmx3, Drosophila Hmx can substitute for the mouse Hmx3 gene in CNS development and, surprisingly, can also direct development of the inner ear. Therefore, a Drosophila gene can direct formation of an organ system that does not even ...Joslin President awarded medal from international diabetes organization
...ve conducted a series of studies using genetically engineered mice with knocked out insulin receptors in classical target tissues, such as liver, muscle and fat. These experiments indicated the important link between obesity, diabetes and longevity. Using these techniques, Dr. Kahn and colleagues in Germany w...OutFoxed! New research may redefine late-stage cardiac development
...s into the four-chamber heart. Using genetically engineered mice, Penn researchers successfully inactivated the Foxp4 binding protein, which resulted in the inability of the bilateral tubes to fuse. They found that each region of pre-cardiac cells still developed into a single tube, and then further developed...Common cold virus can cause polio in mice when injected into muscles
...irus called Coxsackievirus A21 into mice that were engineered to be susceptible to this particular virus. Howeve...CD155 receptor. However, the mice were genetically engineered to have only the Coxsackie A21 receptor, called ICAM-1, and they did not have the poliovirus recepto...Genetic map of important tree genes outlined
...ge part of the unease about the use of genetically engineered crops in agriculture, Strauss said. The researchers in their new report pointed to trees as "a life form of paramount importance for terrestrial ecosystems and human societies," because of their ecological dominance and provision of so much energy an...Single isolated mouse skin cell can generate into variety of epidermal tissues
...hen be expanded in the lab, and grafted on to mice engineered not to reject the cells, to see if new hair and other epidermal tissue will grow. As part of the Robert and Harriet Heilbrunn Center for Stem Cell Research that was established in August 2004 at Rockefeller, Fuchs' laboratory is among the six on Roc...Molecular staples shape a cancer killer
...the peptide to unfold." The researchers dubbed the engineered peptide "stabilized alpha-helix of BCL-2 domains" (SAHB). The BCL-2 family of proteins regulates apoptosis. When the researchers examined SAHB's properties, they found that it assumed a stable alpha-helical shape, bound to the right protein to trigg...Diabodies act as guided missiles targeted to mammary tumor growth
...er, Philadelphia, Pa. Diabodies are genetically engineered dimeric proteins produced in E. coli bacteria that...ch smaller than native antibodies, the genetically engineered protein is cleared much quicker from the body, Adams said. However, the affinity that the diabody ha...Study reveals first genetic step necessary for prostate cancer growth
...issue of Cancer Research, found that when mice are engineered to lose a single copy of a gene called Rb in their...eveloped a system using mice that were genetically engineered to self-destruct one or both copies of its Rb gene in prostate cells. The important difference betwe......s, Stern and Xu, along with Juhie Lee, M.D./Ph.D., engineered cells with reduced microcephalin. They found that when they damaged the DNA in these cells with radiation, the checkpoint response was impaired. They also found that, like other mediator proteins, microcephalin is recruited to sites of DNA breaks. ...