Wisconsin scientists develop quick botox test
...een for (agents) to block any one of those steps," explains Chapman. "We could screen one million drugs at a time, and you can do all the screening using live cells." The potential upshot of such a screening technology could be the development of drugs that act like a prophylactic to confer protection from bo...Certain genes boost fish oils' protection against breast cancer
...k down-were behind the protection. Gago-Dominguez explains that certain enzymes in the body known as glutathione S-transferases (GSTs, for short) help the body flush out and get rid of these lipid peroxidation products. Each person has certain genes that carry the recipe for making GST. But interestingly, th...Experimental drug shown to block mutant protein causing blood disease
...drugs are opening more doors to treating cancers," explains Stone. Tyrosine kinases are molecules that act as biological switches inside cells, regulating processes including cell division and growth. Abnormal kinases have been discovered to be major culprits in many forms of cancer. Because inhibitor drugs s...Targeted therapy knocks out pediatric brain cancer in mice
...improved significantly in the last three decades," explains study author Dr. Tom Curran from St. Jude Children's Research Hospital in Memphis, Tennessee. "This is partly due to the absence of adequate model systems for testing novel therapies." Dr. Curran and colleagues used a mouse model of medulloblastoma t...Researchers develop fast track way to discover how cells are regulated
...with a problem -- the incredible number of genes," explains Susan Mango, Ph.D., an HCI investigator and leader...which shares many genes in common with humans. She explains that although worms appear simple, the worm genome is comprised of 20,000 genes. The human genome ha...Popular Science announces Third Annual 'Brilliant 10'
...sis makes sense over a wide range of scenarios and explains some of what we know about the moon and Earth today. Someday, her simulations may predict which planets outside our solar system contain moons like ours. Maria Chudnovsky , 27, Princeton University, (Princeton, NJ) for her work in the field of ma...New fruitfly model of diabetes has future implications for pancreatic cell transplantation
...es between the insect and human pancreas, Rulifson explains that now the fly can serve as a simple model of ho... grow islet cells for cell-replacement therapies," explains Rulifson. "We're trying to identify a molecular roadmap for a normally developing beta cell, which m...Can an old gene learn new tricks?
... combinations that are specific to the new organ," explains Dr. Lufkin....UCLA molecular biologists uproot the tree of life
...ake, UCLA professsor of molecular biology. "A ring explains the data far better." Lake initially titled the Nature article, "One Ring to Rule Them All." The ring of life has significant implications for eukaryotes (cells with nuclei), the group that includes all multicellular forms of life, such as humans, an...Extreme stretch-growth of axons
...normous growth, you can't just spring it on them," explains Bryan Pfister, PhD a post-doctoral fellow in Smith...he stretch is coming from the whole body growing," explains Smith. "For example, the growing spine bones in the whale likely exert mechanical forces on the axon...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...yzing these two molecules in the lymphoid tissue," explains Giordano, an internationally recognized researcher in the genetics of cancer and gene therapy. "The change of levels of CDK9 and CYCLIN T1 in lymphoid cells shows a correlation with activity of the cancer. The higher the expression of the gene and t...How an insidious mutation fools DNA replication
...the cellular enzyme that copies DNA. Their finding explains how oxidative DNA damage -- a process long believed to underlie cancers and aging -- can create permanent genetic damage. The Duke University Medical Center researchers' findings were published online Aug. 22, 2004, by the journal Nature. The scienti...Humans march to a faster genetic 'drummer' than primates, UC Riverside research says
...s a chemical process within human chromosomes that explains why humans have an explosive expansion of DNA repeats, and primates do not," Dugaiczyk said. Determining the genetic differences between humans and primates is important for several reasons, Dugaiczyk said, including advancing knowledge about how li...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...volves a host-encoded antiviral factor, APOBEC3G," explains Greene. "We all produce this factor. It's quite po...arget since the discovery of chemokine receptors," explains Greene. While the future of HIV therapeutics is brightening, it is essential that these drugs be mad...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...ratus and is stripped off in the course of entry," explains Dormitzer, who also is an assistant professor of Pediatrics at HMS and is affiliated with HMS's Center for Molecular and Cellular Dynamics. "Its job is to get the innermost portions the genes and the replication machinery -- inside the cell." Fro...Computer database being developed at Temple will allow for better inventory of chemicals
...ar individuals who work in the labs have received, explains Rappaport. Some of the training--for people who work with blood-born pathogens, for example--has to be renewed every year. The database would monitor the training certification and send an automatic alert when it is about to expire. The same...Penn scientists identify novel pathway in aneurysms
...the progressive damage may have already occurred," explains Funk. "This is a surprising finding since at first we weren't even looking for aneurysms, we were trying to confirm the arteriosclerosis-leukotriene connection," comments Zhao. The researchers found the 5-lipoxygenase enzyme mainly in macrophages in ...Why damaged DNA gets a case of the bends
... of damaged DNA to date. Further, this flexibility explains how the body's enzymes recognize and fix damaged DNA. "There's a lot of discussion in the literature about how damaged DNA is recognized by the repair enzymes," said Maciej Haranczyk, a staff scientist at the Department of Energy's Pacific Northwest ......"The repeats are read along with the normal gene," explains Schulze-Lefert. "The original reading frame cannot be recognized anymore and the MLO protein is therefore no longer produced in the cells." Even in the rare cases where the reading frame is detected by enzymes, the MLO protein can be produced in mini......pollen and made very few seeds. Davis thinks this explains why Spartina covers only 60 of Willapa Bay's 230 acres, despite having been present in the bay for a century. The study's findings are helping biologists devise new strategies to eradicate invasive species. Davis says inefficient wind pollination cou...