Tag: "familial" at biology news

A liking for sweets, combined with novelty seeking, may predict alcoholism

...ic control subjects, as well as in patients with a familial form of alcoholism, compared with patients with nonfamilial forms of alcoholism, said Kampov. It is believed that high novelty seeking causes early experimentation with alcohol and, as a result, higher lifetime rates of heavy drinking, alcohol abuse...

Researchers discover why mutant gene causes colon cancer

... an inherited colon cancer predisposition known as familial adenomatous polyposis (FAP) that occurs in people who have APC mutations. In this inherited syndrome, hundreds to thousands of pre-cancerous growths called adenomatous polyps form in the colon, usually beginning before a person is 16 years old. The l...

Location of potential familial lung cancer gene discovered

...isk for carriers and non-carriers of the predicted familial lung cancer gene. They found that in non-carriers...tinue screening additional families who could have familial lung cancer, to confirm this particular susceptibility region, and perhaps find additional regions. ...

FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition

...cholesterol in patients with primary (heterozygous familial and non-familial) hypercholesterolemia or mixed hy...ol and LDL cholesterol in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g. LDL apheresis) or if su...

Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)

...ty-one infants to this sudden death syndrome. This familial clustering suggested a genetic basis for the syndrome. All infants with SIDDT died before 12 months of age of abrupt cardiac and respiratory arrest. While many of these infants underwent testing at major medical centers, no abnormalities were found. ...

Genetic model for devastating form of paraplegia suggests new treatments

...the inherited genetic disorder. HSP--also known as familial spastic paraparesis and Strumpell-Lorrain syndrome--causes the ends of the nerves that control muscle activity to deteriorate. These nerve cells run from the brain's cerebral cortex to the spinal cord where they connect to "downstream" nerve cells th...

Other highlights in the July 7 JNCI

... syndromes MEN2A and MEN2B or the related disease, familial medullary thyroid carcinoma. Patients with medullary thyroid carcinoma can only be cured through surgery, which is only be performed before the cancer has metastasized clinically, as the cancer does not respond to standard chemotherapy or radiation. ...

Hopkins to found first center for comprehensive study of epigenetics

...ndic Heart Foundation boast great documentation of familial relationships, medical histories and thorough and quantitative medical examination to go along with blood and tissue samples," says Feinberg. "There is great scientific value in what they have and what they do." In particular, Feinberg points out tha...

Study sheds new light on genetic risk for Parkinson's disease

...-4 is a major susceptibility gene for sporadic and familial Alzheimer's disease and has been associated with poor clinical outcome in people with acute head injury and stroke," Huang said. "In the brain, apolipoprotein E-4 may be involved in neuron repair and in the removal of dead cells, so if you have APOE-...

Altered protein involved in a novel link to Alzheimer's disease

...poradic Alzheimer's (as opposed to the less common familial form of the disease) and also why stroke and high blood pressure increase the likelihood of developing Alzheimer's. Dr. Li-Huei Tsai, a Howard Hughes Medical Institute investigator at Harvard Medical School, presented the latest discovery mad...

UCSD finds genetic time bomb in heart that leads to heart failure in some patients

... progressive heart failure occurs in patients with familial forms of congenital heart disease called atrial septal defects, even after the malformation is surgically corrected. The researchers believe that their findings could, potentially, apply to other forms of congenital heart disease, as well. ...

Sodium channel gene mutation identified in case of familial epilepsy

...eat patients and their families who have a type of familial epilepsy called generalized epilepsy with febrile ...ddy. "And, with our recent finding in this form of familial epilepsy, I think we are on the right track." The GEFS+ mutation presentation will be highlighted i...

Gene-rich human Chromosome 19 sequence completed

...ndent diabetes, myotonic dystrophy, migraines, and familial hypercholesterolemia (an inherited form of elevated blood cholesterol), which increases the risk of cardiovascular disease. Beyond the significant revelation that chromosome 19 has more than twice the gene density of the genome-wide average, it also ...

Research on inherited eye disorders uncovers new information about blood-vessel formation

...tudied two inherited disorders, Norrie disease and familial exudative vitreoretinopathy (FEVR), whose underlying genetic defects were already known, but whose mechanistic relationship was not. Norrie disease, caused by a defect in the gene for the protein Norrin, produces congenital blindness and a progressiv...

UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders

...998 researchers localized a human gene that caused familial partial lipodystrophy, called Dunnigan type (FPLD)...utation PPARγ was linked to another type of familial partial lipodystrophy. In 2002 the mutated gene, AGPAT2, linked to congenital generalized lipodystr...

Migraine mouse provides insight into neurobiology of devastating headaches

...n Italy examined a rare subtype of migraine called familial hemiplegic migraine (FHM) that is identical to other types of migraine except it is also associated with hemiparesis, weakness on one side of the body. FHM is associated with specific genetic mutations in a gene for a calcium channel protein that is ...

Cancer rates in teens and early 20s rising

...to undertake international comparisons. Studies of familial patterns will also be important. Then we would have a proper basis for detailed molecular epidemiological studies that could really help us to identify the causes of the cancers that are affecting our young people."...

New findings are a window into the late stages of 'Lou Gehrig's' disease

...nts. The researchers were also able to distinguish familial ALS (FALS) from sporadic ALS (SALS). They believe ...from five individuals with sporadic ALS and 2 with familial ALS. All samples were frozen and frozen tissues were dissected to separate gray and white matter an...

Activation of receptor ups development of precancerous intestinal polyps

...uals with an inherited form of colon cancer called familial adenomatous polyposis (FAP) and is seen in 80 percent of sporadic colorectal cancers, so the mutation is highly relevant to colorectal cancer in humans," DuBois said. In line with published data, the untreated mice developed an average of 30 ...

Other highlights in the January 21 issue of JNCI

...o psychological outcomes of genetic counseling for familial cancer, Dejana Braithwaite, of the Institute of Pu...hat, in controlled studies, genetic counseling for familial cancer was associated with improved knowledge of cancer genetics but did not alter the level of perc...

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