Tag: "fibrosis" at biology news
Bacterial Toxin Surprises Scientists
... certain toxins, but on diseases like cystic fibrosis
that result from defects in natural membrane channels. "If we could understand how this protein works, we might understand more about how proteins are normally moved across and inserted into membranes," said the stud...
Erodible plastic microspheres could be effective oral drug delivery system
...apy for a number ofgenetic diseases such as cystic fibrosis
and hemophilia. Edith Mathiowitz, who led the study, thinks the enhanced absorption relatesin part to the small size of the spheres and the adhesive nature of thepolymers. The spheres were engineered to stick tightly to and even penetratelinings in...
Cystic Fibrosis Foundation Launches Innovative Therapeutics Development Centers
...d care centers across the country. Cystic fibrosis
is a complex, fatal genetic disease that affects a...lopment of the means to cure and control cystic fibrosis
and to improve the quality of life for those with the disease....
American Society Of Gene Therapy To Hold Its First Annual Meeting
..., cardiovascular diseases, genetic diseases,cystic fibrosis
and lung diseases, neurological and neuromuscular disorders, andstem cell gene therapy. More than 750 abstracts have been submitted for presentation and aplenary session will present the best eight papers selected. In addition, 18sessions of...
Scientists Discover A Secret Of Bacterial Communication
...cal implants, and causes lung infections in cystic fibrosis
patients,secretes two signal molecules that accumulate as the number of bacteria on asurface increase. When the signal molecules reach a specific concentration theyinitiate various cell activities. Both turn on the genetic machinery thatproduces bact...
MSU Scientists Eavesdrop On Bacterial
...nfections and a key player in infections in cystic fibrosis
patients, accordingto Davies. The bacteria are excreting homoserine lactones all the time, but whenenough bacteria gather, something called quorum sensing occurs. The homoserinelactones start to diffuse back into the cells and trigger geneti...
Cystic Fibrosis Gene Protects Against Typhoid Fever
The gene mutation that causes cystic fibrosis
also appears to protect againstinfection with typh... research." Approximately 2,500 babies with cystic fibrosis
are born each year in the UnitedStates. Before the 1950s, most children with the disease died by ag...
Killing Fields: A Bacterial Pesticide May Threaten Human Life
...ost antibiotics and kills around a third of cystic fibrosis
patients it infects within a year. Goldstein has studied an outbreak of B. cepacia at the University of Mississippi Medical Center three years ago, in which 300 patients were hit. DNA analysis suggests that the infection had passed between pa...
False Security: You Can't Always Believe The Results Of A Genetic Test
...any laboratories offering genetic tests for cystic fibrosis
don't test for enough mutations to give reliable r...tify 90 per cent or more of people carrying cystic fibrosis
genes, it may be necessary to test for 20 of the most common mutations, Grody predicts. Gro...
Molecular "Fossils" Of Early Life
...potentialfor treating diseases ranging from cystic fibrosis
to muscular dystrophy andsickle cell anemia. Because DNA lends itself well to test-tube evolution techniques, it canbe synthesized readily in the laboratory, and different strains of enzymes canbe genetically engineered for specific purposes,...
Successful Specialist Care For Cystic Fibrosis Patients From Childhood To Adulthood
... The longer-term prognosis of patients with cystic fibrosis
can be improved if patients are treated at both paediatric and adult cystic fibrosis
centres. Therefore it is the clinical responsibility of all physicians to ensure that specialist ca...
Shellfish Toxin Study Provides Possible Clue To Cystic Fibrosis Therapy
... Europe and Japan. The symptoms of cystic fibrosis
arise from there being a genetic blockof a major p...e lungsand gut and predisposes people with cystic fibrosis
to severe bacterialinfections and early death. Dr. Shears said, "Our group of cooperating sc...
Additional Genetic Influence For Alzheimer's Disease Confirmed
... Unlike genetic diseases such as cystic fibrosis
and Huntington's diseasein which the presence of the gene for these disorders consistently results inhaving the disease, Alzheimer's disease is complex and involves multiplefactors, much like cardiovascular disease. "It's too early to say whether or ...
New Evidence For Growth Factor Role In Crohns Disease
...e wrong cells grow. Thisabberrant growth is termed fibrosis
and is associated with deposition of lots ofcollag...IGFBPs) maybe used therapeutically to help prevent fibrosis
and its complications. An estimated six new Crohn's disease cases per 100,000 population occur in m...
UNC Scientists Succeed In Inserting Gene In Human Cells Via Artificial
...s with variousillnesses such as hemophilia, cystic fibrosis
and sickle cell anemia and improvetreatment. "We have been able to do this with a piece of DNA five to 20 times theusual size scientists work with," said Dr. Jean Michel Vos, associate professorof biochemistry at the UNC-CH School of Medicine...
Debilitating Pancreatic Disorder Linked To Cystic Fibrosis Gene
...ingassociation between the gene that causes cystic fibrosis
and a debilitating formof pancreatitis, inflammati... or 37 percent, showed abnormalities in the cystic fibrosis
gene. "These abnormalities were different from the genetic defects causingclassic cystic fib...
Lack Of Intestinal Bacterium Linked To Kidney Stones In Cystic Fibrosis Patients, University Of Florida Researchers Report
GAINESVILLE, Fla.---Cystic fibrosis
patients who lack a beneficial intestinalbacterium...stals. Previously,many researchers believed cystic fibrosis
patients developed kidney stones inconnection with intestinal malabsorption problems. Cystic fibrosi...
New Drug "Cocktails" Prove Effective Against Hepatitis
...ng the Interferon alfa-2b/ribavirin to treat liver fibrosis
in Hepatitis C patients. The last stage of liver fibrosis
in such patients is cirrhosis, which can be fatal. The huge study of almost 2,000 patients found tha...
UI Researchers Find Potential Gene Therapy For Cystic Fibrosis
...rapeutic genes to the lungs of patients withcystic fibrosis
(CF), the most common fatal hereditary disease in the UnitedStates. The research using human cells in laboratory cultures indicates that the methodcould be used to permanently cure CF and other genetic lung diseases, said PaulMcCray, M.D., associate ...
UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
...king this gene, the lungs do not develop pulmonary fibrosis
inresponse to a drug that normally induces the condition. But there is more to the story. The researchers also discovered that theintegrin must interact with parts of a cell's rigid internal scaffolding, knownas the cytoskleton, before it can activa...
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