Genetic mutations linked to the practice of burning coal in homes in China
... mutations. Damage to both p53, a tumor suppressor gene that prevents normal cells from turning into tumor cells, and K-ras, an oncogene, is fundamental to the development of a vast majority of cancers. Mutations to both p53 and K-ras are thought to be primarily caused by chemicals called polycyclic aroma...Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
... government to isolate from an indigenous tree the gene for a promising anti-AIDS drug and to share any ro...Samoa's assertion of national sovereignty over the gene sequence of Prostratin, a drug extracted from the bark of the mamala tree (Homalanthus nutans). The ...Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
... government to isolate from an indigenous tree the gene for a promising anti-AIDS drug and to share any ro...Samoa's assertion of national sovereignty over the gene sequence of Prostratin, a drug extracted from the bark of the mamala tree (Homalanthus nutans). The ...Researchers determine genetic cause of Timothy syndrome
.... Studies of the pattern of activity of the gene for the channel in humans and mice revealed that i...particular, said Keating, mouse studies showed the gene to be active in brain regions that were known to show abnormalities in autism. Cell cultur...Rare childhood genetic syndrome identified
... it arises from a single, spontaneous, very subtle gene mutation in the mother's egg or father's sperm su...me, Keating says. Experiments also showed that the gene encoding the calcium channel was active not only in heart muscle cells, but in tissues of the gastro...Gladstone investigator Mike McCune wins prestigious NIH Director's Pioneer Award
... stem cells and the application of stem cell-based gene therapy for the treatment of HIV disease. McCune, who joined the Gladstone Institute of Virology and Immunology in 1995, has been associated with UCSF since the beginning of the AIDS epidemic, first as a resident and subsequently as a faculty m...New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...grammed cell death. It also appears to correct the gene responsible for making a flawed protein (the PMLRA...firm the diagnosis of APL by identifying the rogue gene in their study patients. This further enabled them to establish a new classification for acute myelo...Pack-MULEs are toting a new look at plant evolution
...logy. "Pack-MULEs: transposable elements mediate gene evolution in plants" may sound like a western lost...e element, an element that inserts itself into the gene that is responsible for the purple color. The transposable element jumps out and purple spots appear...UT Southwestern biochemist honored with NIH Director's Pioneer Award
...arly work on transcription factors to the study of gene regulation in the brain. One of his current projec...ries of the mechanisms responsible for controlling gene expression are truly worthy of this recognition by the NIH." Dr. Alfred Gilman, Nobel laureate...New molecular link key to cellular proteins involved in cancer progression, other diseases
...llows greater understanding of how expression of a gene can go awry and may identify a potential target fo...r is to regulate processes involving DNA including gene expression, or transcription." In 1975, histone H2A was the first molecule ever described to be ubiq...Safety of isoflavones in dietary supplements targeted by Illinois initiative
...ell and structural biology, will study patterns of gene activation affected by isoflavones through both es...eceptors in breast tumors. They also will examine gene regulation in breast tumor systems, especially those adapted to changes in hormone responsiveness, a...Phase II trials of second-generation antisense cancer drug planned following successful early study
...s demonstrated that the new drug blocks its target gene in exactly the way it is designed to do. In the Phase I study the drug OGX-011* inhibited the production of clusterin, a protein that protects cell survival and is widely distributed in body tissue. Clusterin is implicated in a range of activities,...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...l. Portnoy thought that if he could eliminate the gene for ActA, he could prevent the bacteria from forming actin motors and spreading from cell to cell. The technique worked, and Cerus adapted one of Portnoy's attenuated strains for its vaccine. The particular strain Cerus plans to use for its clinical ...Award winning researchers reveal potential new role for Glivec
... team published in 1997[4] . This had shown that a gene called the platelet-derived growth factor receptor B (PDGFB) was re-arranged in DFSP, involving a translocation between chromosomes 17 and 22. "It was intuitive to try imatinib in the disease because this translocation results in over expression of ...Trial shows which brain cancer patients benefit from temozolomide
...g which patients will gain from temozolomide was a gene called O-6-methylguanine-DNA methyltransferase (MG... use. If the MGMT promoter is methylated, the MGMT gene is silenced and this means that no MGMT repair enzyme will be produced, thus preventing correction o...New research shows plants can shuffle and paste gene pieces to generate genetic diversity
...rsity in St. Louis, discovered that capturing rice gene fragments is a way of life for one type of TE called MULEs. MULEs with captured gene fragments were called Pack-MULEs. The study identified more than 3000 Pack-MULEs that contained ove...Genetic differences might help distinguish thyroid cancers
...tens of thousands of genes at one time, to compare gene activity in cells from six PTC tumors, nine FTC tumors and 13 samples of normal thyroid tissue. The PTC cells showed over-expression of genes known as CITED1, claudin-10 (CLDN10), and insulin-like growth factor binding protein 6 (IGFBP6). It al...Gene clusters predict atherosclerosis severity, susceptibility
... factors. "Instead of trying to find a specific gene that might be implicated in the development athero...ke atherosclerosis, it is not likely that only one gene is involved, but many different ones that interact with each other," said Seo. Specifically, the...UCSF scientist Joe Derisi named MaCarthur Fellow
...ns and builds microarrays -- a technology in which gene activity is revealed on a glass slide -- to carry ...ir analysis showed that the pattern, or timing, of gene expression was unique, with most genes expressed only once during the stage, and in a certain order,......s Hospital Medical Center have identified a master gene that controls the first breath a newborn infant ta... (PNAS). "It was surprising to us that a single gene was able to orchestrate so many other aspects of lung function we know are critical for survival at ...