Phase II trials of second-generation antisense cancer drug planned following successful early study
... (mRNA) was down to a mean 8% level as compared to historical controls. The drug was well tolerated by patients. Said Dr. Chi: "We designed the Phase I trial in such a way that we could identify the biologically active dose in the tumour tissue. Being able to identify the active dose in this way gives us confid...'Most recent common ancestor' of all living humans surprisingly recent
... barriers of geography and migration, and recorded historical events. Although such complexities make pure mathematical analysis difficult, it was possible to integrate them into an elaborate computer simulation model. The computer repeatedly simulated history under varying assumptions, tracking the lives, move...Bronfenbrenner book sums up human development
... together and published a new book that traces the historical development of his groundbreaking bioecological model of human development and detailing how it can be applied via programs and policies. Making Human Beings Human: Bioecological Perspectives on Human Development (Sage Publications, 2004) is Bronfe...USC study links historical increases in life span to lower childhood exposure to infection
...biology of Aging. "Our main point is that in historical times when there was a lot of childhood mortality, even kids that didn't die got chronic infections. Those chronic infections from childhood onward accelerated vascular and other diseases," he said. Finch and Crimmins, holder of the Edna M. Jon...Complex cells likely arose from combination of bacterial and extreme-microbe genomes
...ciplines of science and engineering--to re-examine historical schemes for classifying Earth's living creatures, a process that was once based on easily observable traits. Microbes, plants or animals were said to be related if they shared certain, mostly physical, characteristics. DNA technology now allows much...Do genes respond to global warming?
...adly et al. asked how the two species responded to historical climate-induced habitat alterations in northwestern Wyoming. They gathered fossils from Yellowstone National Park's Lamar Cave, and compared genetic material extracted from fossil samples taken from different time points over the past 3,000 years to ...New hypoxic event found off Oregon coast
...s in 2002 were just off the charts compared to the historical norm, and already this year we have had some readings in that same range," Chan said. "One recent measurement taken at a 30 meter depth station just 1.2 miles off Newport found dissolved oxygen at 0.8 milliliters per liter. Further offshore and to th...Parasitic cowbirds thrive with a less ruthless strategy than cuckoos
... cowbird. The study notes that among the cowbird's historical hosts, you typically find two eggs with a single cowbird egg. The phoebe is a new host, with an average clutch size of five eggs. "This was a very experimental study, combining some specific predictions from the literature with a purely experimental ...Climate change could doom Alaska's tundra
.... Temperatures have already been above the historical norm in Alaska for the past 17 years. But about 100 years from now, the average annual temperature in Alaska may soar up to 13 degrees Fahrenheit higher in the worst case scenario predicted by climate models.Tundra is a cold, comparatively dry ecosys...APS/IUPS launch PHYSIOLOGY bimonthly
...sions of opposing viewpoints Timelines: brief historical articles describing how a particular field developed to where it is today, sometimes linked to current reviews in Physiology. Dale Benos, chair of the APS Publications Committee, said: "Walter Boron has assembled an outstanding, enthusiastic and ...Satellites are tracing Europe's forest fire scars
... scar mapping product from Risk-EOS to have a good historical basis of information," Raffalli added. "The benefit is that it makes possible a much more effective protection of the forest." Characterising the sites of past fires to a more thorough level of detail should mean that service users can better foreca...Myths surrounding Cuyahoga River fire 35 years ago
... 22, 1969, a river started on fire. So begins the historical event that has turned into the fable of the Cuyaho...f the Clean Water Act of 1972. Adler also laid the historical groundwork of how Cleveland had passed a $100-million bond issue in 1968 to clean up the water (the ...All ecosystems are equally productive under drought conditions
...xman said, "For any ecosystem, if rain falls below historical minimums, our model predicts pretty substantial reductions in productivity." Plants won't buffer the effect of climate change on ecosystems, but rather exacerbate it, making the world a more uncertain place, he said. "There's enhance...International research conferences at the Villa Vigoni
...ious aspects of this topic using, for example, the historical parks of the Villa Vigoni itself. Another objectiv... and spread of these religions in Antiquity from a historical perspective (for further information contact: Professor Jrg Rpke, University of Erfurt, Tel.: 49-0-3...Computer model shows increased US threat from soybean rust
...the same places every year," Isard said. "Based on historical weather data over the last 30 years, we predict that there would be outbreaks in about three of every four years in the major soybean areas."...Promising research: From employment issues to virology
...ians hope to achieve a better understanding of the historical development of Europe by studying transcultural relationships. (Coordinators: Professor Dr. Michael Borgolte, Humboldt University of Berlin and Dr. Bernd Schneidmller, University of Heidelberg) Engineering Sciences In the future, demands will be m...Archaeologists announce discoveries at the ancient Maya site of Waka' in northern Guatemala
...ed research serves to both test and supplement the historical record. The project's excavations have focused on a number of important areas of the site, looking into the past activities at locations of both ritual and residential activity. The large ceremonial complex in the southeast portion of the site cente...DFG establishes first German-Sino Research Training Group
...he relationship between history and the media. The historical starting point are the radical changes caused by n...he 19th century as well as the emergence of modern historical concepts that have developed from the tension between events and process since the end of the 18th c...U.S. President's budget proposal means 5-year cuts 'well below historic levels'
... leave key programs with budgets well below recent historical levels," said Kei Koizumi, who handles federal R&D budget analysis for AAAS. "Particularly during a Presidential election year, it's important for policymakers and taxpayers to understand the impacts of any federal budget changes, especially any prop...2004 Wistar Institute Science Journalism Award winners announced
...the future of genetics rather than dwelling on the historical importance of the earlier research. The award is given jointly because the judges wanted to acknowledge the parallel achievement of the writers for the clear and informative presentation of epigenetics to a general audience by Ambrose and the sophist...