World Congress on Huntington's Disease to meet in Toronto, August 16-19, 2003
(Toronto, Ontario, Canada) -- Huntington's disease (HD) researchers, clinicians, and members of the HD community from around the world will convene August 16-19 in Toronto, Ontario, Canada for the World Congress on Huntington's Disease. A scientific program will feature presentations on the genetics and mechanisms of HD, as well as recent discoveries and experimental treatments. Research clinicia...Link between neuronal calcium channel, mutated gene that causes Huntington's disease identified
DALLAS July 17, 2003 Abnormally high calcium levels spurred on by a mutated gene may lead to the death of neurons associated with Huntington's disease, an inherited genetic disorder, characterized by mental and physical deterioration, for which there is no known cure.... ...This discovery by researchers at UT Southwestern Medical Center at Dallas, published in the current issue of Neuron, sheds...USING gene therapy to switch off genes instead of adding new ones could slow down or prevent the fatal brain disorder Huntington's disease. The method, which exploits a mechanism called RNA interference, might also help treat a wide range of other inherited diseases. ..."When I first heard of this work, it just took my breath away," says Nancy Wexler of Columbia University Medical School, who is...Fasting forestalls Huntington's disease in mice
Decreasing meal frequency and caloric intake protects nerve cells from genetically induced damage, delays the onset of Huntington's disease-like symptoms in mice, and prolongs the lives of affected rodents, according to investigators at the National Institute on Aging (NIA) Intramural Research Program. This animal study* is the first to suggest that a change in diet can influence the course of Hu...Novel gene mutation causes Huntington's-like symptoms, providing window into how brain cells die
"This is a rare version of an already rare disorder, but the mutation that causes it may not only help us better understand Huntington's Disease, but could boost our understanding of many other neurodegenerative disorders . . ." Russell L. Margolis, M.D.... ... Researchers at Johns Hopkins have discovered a gene mutation that causes a condition apparently identical to Huntington's Disease, helpi...Bile acid inhibits cell death in Huntington's disease
MINNEAPOLIS / ST. PAUL (July 24, 2002)--University of Minnesota researchers have found that a nontoxic bile acid produced in the body prevents apoptosis, or programmed cell death, in mice with Huntington's disease. This finding, to be published July 29 in the Proceedings of the National Academy of Sciences USA (PNAS), may eventually lead to a treatment for Huntington's disease (HD) in humans. HD...Stanford researchers home in on Huntington's disease treatment
STANFORD, Calif. - Stanford University Medical Center researchers have discovered a potential treatment for Huntington's disease. By enhancing the brain's natural protective response to the disease, researchers were able to alleviate the uncontrollable tremors and prolong the lives of mice with a neurological disorder that mimics Huntington's. Their finding suggests that a similar treatment str...Trial drugs for Huntingtons disease inconclusive in slowing disease
A large-scale clinical trial that tested the ability of the investigational drugs remacemide and Coenzyme Q10 to slow the progression of Huntingtons disease showed that neither drug resulted in any significant improvement for the patients. Although after one year of treatment, the disease seemed to progress more slowly in patients treated with Coenzyme Q10, the investigators say that overall th.....Stanford researchers have found an answer to a long-standing mystery surrounding Huntingtons, Alzheimers, Parkinsons and other neurodegenerative diseases. . .Their discovery, published in the May 25 issue of the journal Science, focuses on one of the telltale signs of neurodegenerative illness: the mysterious buildup of defective proteins in and around nerve cells. . .Healthy cells have the ab.... . . . Huntington's disease affects nearly 30,000 people nationwide, with another 150,000 at risk for inheriting the disease. Like a genetic time bomb, one abnormal gene in Huntington's victims disrupts the brain's nerve cell functions, slowly degrading physical, intellectual and emotional capability and leading inevitably to death. . . In a collaborative study conducted by the Fred Hu...... ... For more than a century, tremors and jerky movements have been recognized as the... hallmarks of Huntington's disease (HD). Scientists have long known these motor control... disturbances result from damaged brain cells. Now, researchers at Johns Hopkins think they... may have identified the nervous system mechanism linked to these symptoms and the part of... the brain causing them...Weizmann researchers find evidence that links molecular mechanism to Huntington's Disease
.Weizmann researchers have found evidence that an enzyme called transglutaminase.(TGase) may be the "smoking gun" behind the deadly disease Huntington's disease.(HD). Their study is reported in the June 22 issue of the Proceedings of the.National Academy of Sciences.. .TGase occurs naturally throughout the body, and is catalyst for processes.associated with healing, such as skin formation and wo...Mouse Model For Huntington's Disease Developed By NIH, Vanderbilt
. Scientists at the National Institutes of Health, in collaboration with a.Vanderbilt University Medical Center neuropathologist, have genetically.engineered and studied mice that mimic the behavioral and pathological changes.of Huntington's disease.. The achievement holds promise as an important step in understanding the.role of the Huntington's disease (HD) gene, which was disco...New York, N.Y., August 8, 1997- Nearly 20 years ago, Columbia University.researchers observed brain cell changes in Huntington's disease patients. Today,.the significance of those changes has finally been explained--and the new.findings may lead to a treatment or cure for the progressive, degenerative brain.disease. . In the August 7 issue of Cell, Dr. Gillian Bates of the Division of.Med...