International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...red. This was still a subject of research. "We saw independently reviewed partial tumour responses in 12% of patients and a median survival time of 6.6 months," he said. "In total, 87% of patients developed this acne-like rash. Of the 46 patients who did not develop a rash none had a tumour response and their medi...Pollutant causes delayed flowering in plants
...ght, while others are autonomous pathways that act independently of external cues. "However, nobody knew that nitric oxide was involved in these pathways. And nobody knew that plants would be affected by external concentrations of nitric oxide, as might be caused by air pollution." Such biochemical pathways are n...Prion propagation: Avoiding the toxic oligomer
... These results show that amyloid growth can occur independently of oligomers. Since many of the properties observed in Sup35 polymerization are evident in other amyloid-forming proteins, the model presented here may be shared as well. Future studies will have to explore this question, along with the issues of how...Chernobyl study: Risk of thyroid cancer rises with radiation dose
...ct that all cases of thyroid cancer were confirmed independently by a panel of expert pathologists, and the study focused on people exposed as young children and adolescents, a group that is likely to be most susceptible to the effects of radiation exposure to the thyroid gland. Limitations of the study included i...Scientists discover proteins involved in spread of HIV-1 infection
...nting infection from spreading. These results were independently confirmed by another research group led by Harald Stenmark of the Norwegian Radium Hospital in Montebello, Norway. Stenmark's group also discovered the same group of human VPS37 proteins and published their results in the September issue of Molecul......their own way, and they all reset their own clocks independently of one another. The heart, for instance, is like an obsessive-compulsive clock watcher. It monitors the master clock closely and trains its circadian rhythms to changes in the master clock rapidly. The liver, on the other hand, is more slothlike...Using statistics to decipher secrets of natural mutation
... treated all positions in the sequence as evolving independently of each other, rather than taking into account context effects, in which the identity of neighboring nucleotides influences the nature and rate of mutations. "While a few other investigators have been working on how to take into account context eff...You are what you eat: New insight into autophagy
...ion of cell growth and inhibition of autophagy are independently controlled outputs of TOR. ...NRH1 and Wnt signaling come together in convergent extension
...rz7 or NRH1, but it was found that NRH1 functioned independently of Xdsh, another upstream regulator of Rho-family small GTPase activity in the Wnt/PCP pathway. The transduction mechanisms by which NRH1 interacts with Wnt/PCP signaling factors remain to be worked out, as do the specifics of the inter-related but a...Mutant mice lead to memory insights
...ise healthy individuals. Two groups of researchers independently studied mutant mice deficient in "CREB binding protein" (CBP), which is a common target in patients with RTS. CBP is so named because it binds a key gene-regulating protein called CREB that is important for many functions including memory in animals ...Molecule that 'blocks' key bacterial enzyme may lead to new antibiotics
...rs, The State University of New Jersey, discovered independently that MccJ25 uniquely blocks a "tunnel" into the bacterial enzyme, RNA polymerase (RNAP). The "tunnel" is used to bring raw materials for RNA synthesis into the enzyme and to expel byproducts of RNA synthesis. "Closing the crowded, two-way '...Study links diabetes and colorectal cancer
...hat glycated HbA1c could predict colorectal cancer independently of diabetes and such other risk factors as obesity and cigarette smoking and do so at concentrations below those commonly accepted as the standard for a diagnosis of diabetes. For every one percent increase in glycated hemoglobin there was a corresp...Moving targets: when it comes to patterns, motion gets factored in
... visual cortex initially analyzes spatial patterns independently of their movements, but Nishida's observations provide strong evidence against this basic hypothesis. The new work utilized a visual illusion called multi-slit viewing, first reported in the 1970s. During this illusion, a pattern presented through st...Cell division can be halted in multiple ways, with implications for cancer
...nd stop dividing. The team found that p16 operates independently from telomeres. Sedivy said that p16, p21 and the upstream components that regulate senescence switches would all make compelling subjects of study for pharmaceutical companies, biotech firms and other university researchers. "When it comes to develo...Adaptation, niche conservatism, and convergence
...ain these shared features. Did these traits evolve independently in different lineages, in response to the unique Mediterranean-type climate? Alternatively, did the traits evolve first in response to other factors, subsequently promoting the success of these lineages when summer drought conditions arose in the pas...Once a renin cell, always a renin cell
...rmine the precise cellular function of those genes independently of systemic influences."...Scripps scientists look deep inside sharks and their high-performance swimming system
... and tunas from virtually all other fish and arose independently in each, most likely the result of evolutionary selection for fast and continuous locomotion. Shadwick says in this respect lamnids and tunas are more like each other than they are to their closest relatives. The authors believe the study shows that ...Closing in on the cellular culprits of schizophrenia
...paired in schizophrenia. The study's findings were independently replicated, using two collections of postmortem brain tissue, one maintained by Penn and another by the Stanley Medical Research Institute. "The next step is to understand what dysbindin does in the brain," explains Arnold. "We've found that dysbindi...GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
...acknowledged leaders in the field of HIV/AIDS will independently judge and choose the grant recipients. Although GSK will have access to the applications, including proposals, it will not be involved in the selection of recipients. For purposes of the grant program, the judges will define "drug discovery and dev...Newly discovered gene controls levels of 'bad' cholesterol in mice
...u at the Hospital Necker-Enfants Malades in France independently found that mutations in the Pcsk9 gene were linked to autosomal dominant hypercholesterolemia. But the function of Pcsk9 was not determined until now. To find out what Pcsk9 does, Maxwell inserted the Pcsk9 gene into a virus that targets the liver an...