JCI table of contents September 15, 2004
...... A whole range of human muscular and neuromuscular diseases, are caused by mutations in the mitochondrial respiratory chain/oxidative phosphorylation system. The problem is that there are about 120 genes involved in this system, some that are found in the mitochondria, and thus inherited through the mother, and some that are found in the nucleus and are inherited from both the mother and...JCI table of contents: 1 September, 2004
EDITOR'S CHOICE:... ... ... ...Cervical cancer is the second most common cancer among women worldwide. Research has shown that progression of the pre-malignant stages to invasive cervical cancer is associated with the onset of new blood vessel growth called angiogenesis. Using a mouse model of cervical cancer to explore the molecular control of angiogenesis in cancer progression, Douglas Hanaha...JCI table of contents, 16 August, 2004
... ...Under conditions of stress, molecular mechanisms stop cells from consuming their source of energy, ATP, and trigger them to begin to produce ATP. This is done by inducing cells to stop any biochemical pathways that use energy and by turning on processes that take up glucose and free fatty acids from their surroundings in order to rebuild their ATP reservoir. The main protein involved in...JCI table of contents, 2 August, 2004
...... Stroke is the second largest cause of death worldwide and the leading cause of long-term neurological disability. Therapies for stroke victims are improving, but remain hampered by the limited repair capacity of nerves in the brain and the unique properties of brain vasculature. Akihiko Taguchi and colleagues, of the National Cardiovascular Center in Japan, make great strides in providi...JCI Table of Contents, 15 July 2004
SUMMARIES OF PAPERS IN THIS ISSUE ...Stem Cells Get a Workout ...Female Infertility camp ...Getting to the HAART of Bone Loss ...ApoA-IV has the Guts to Fight Inflammation ...Not by Mutation Identification Alone...... ...Fat Gets Cut Away from Insulin Resistance ...Pulmonary Fibrosis Polarized by Cytokines ...Anuerysms in Allografted aorta ...IDO says Don't to Asthma ...IDO Can Do Anergy ...HCV M...JCI table of contents, 15 June 2004
......Many potentially effective cancer treatments are undone by the onset of resistance to the treatment. In order to circumvent this problem, D. Gary Gilliland and colleagues, of Brigham and Women's Hospital, have developed a strategy using the latest technologies involving small interfering RNA to enhance cancer treatment even in a situation where drug resistance has developed. Small interf...JCI Table of Contents, January 15 2004
......In the January 15 issue of the Journal of Clinical Investigation researchers from Yale University demonstrate that an outer surface protein, OspC, of the organism Borrelia burgdorferi, which causes Lyme disease, is critical for the organism's ability to invade the tick salivary gland and therefore be transmitted from ticks to humans. ......Lyme disease was first named in 1977, when arthrit...JCI table of contents, 1 July 2004
This press release contains summaries of newsworthy papers to be published online on 1 July 2004, in the including: A Pregnant Pause for Unexpected Interactions; Half at the Wrong Time Creates Bad Blood; Cancer Patient, Heal Thyself; PAF-way to Bone Loss; Immunology Link May Make You Lose Your Appetite; and PPAR for the Course. Contact information is included for all authors as well as a direc...JCI table of contents, 1 June 2004
...... Branch points in the arteries are a common area of atherosclerotic disease, resulting in the occlusion of both branches. These branch points can generally be defined as a main branch and a side branch, and, in treating the disease, the question of what is the optimal course of action, opening the main branch, the side branch, or both, remains uncertain. Studies have shown that using a s...JCI table of contents, 17 May 2004
...... Transmissible spongiform encephalopathies (TSEs), such as bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease (CJD) in humans, are all fatal neurological disorders resulting from the deposition of a misfolded form of the prion protein (designated PrPSc) in the central nervous system. Accumulation of PrPSc can also be found in other tissues th...JCI table of contents, 2 April 2004
...... Major diseases of the heart, brain, and kidney all have one thing in common: high-blood pressure as a major risk factor. Hypertension afflicts nearly 50 million people in USA, and over 1 billion worldwide. Although hypertension weighs in heavily on world health, its underlying cause for the vast majority of cases is unknown. One of the known components involved in regulating blood pres...JCI table of contents, 15 March 2004
...... Determining proper treatment for individuals diagnosed with prostate cancer suffers because of the current unreliability of methods to predict the clinical course of the disease. Existing procedures for patient stratification include a series of clinical, biochemical, and histopathological examinations, such as prostate specific antigen (PSA) levels, tumor stage, Gleason score, and gene...JCI table of contents, March 1 2004
...... Preneoplastic lesions, detectable by breast cancer screening, are made up of altered cells that are not themselves cancerous but indicate an increased likelihood that a benign or cancerous tumor may subsequently form. In the March 1 issue of the Journal of Clinical Investigation, Federica Cavallo and colleagues from the University of Turin, Italy, evaluated vaccine strategies for treating...JCI table of contents, 16 February 2004
During mammalian reproduction, including that of humans, large amounts of calcium are transferred from mother to offspring through breast milk. Subsequently, adaptive mechanisms are required to maintain a healthy balance of calcium in the mother's body. These involve the breakdown of calcium stores in bone and increased dietary calcium intake in order to maintain a steady supply of calcium to the...JCI table of contents, February 2, 2004
... ...Type 1 diabetes mellitus (T1DM) is the result of immune-mediated destruction of insulin-secreting pancreatic beta cells. For more than 25 years researchers have searched for an environmental agent or event that triggers this autoimmune response. Past research has suggested that T cells that react to islet beta cells can contribute to the autoimmune response in diabetic patients and also p...JCI table of contents, January 2, 2004
Jaundice, the yellowing of the skin and whites of the eyes following accumulation of the bile pigment bilirubin, is extremely common in newborn infants. In Western nations jaundice is most commonly treated with exposure to light (phototherapy), however a drug therapy would also be desirable. In the January 2 issue of the Journal of Clinical Investigation, David Moore and colleagues from Baylor Co...JCI table of contents, December 15 2003
... ...Normal cell growth requires well-coordinated balance between synthesis and breakdown. Autophagy is a regulated lysosomal pathway whereby long-lived cellular proteins and cytoplasmic organelles are degraded. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. However, little is known about the role of au...JCI Table of Contents, November 3, 2003
... ...In the November 3 issue of the Journal of Clinical Investigation, John Mountz and colleagues from the University of Alabama at Birmingham describe a gene-modified cell therapy utilizing the TRAIL molecule that successfully limits the incidence and severity of arthritis in a mouse model of collagen-induced arthritis and joint inflammation. The regime represents a therapeutic option for sys...JCI table of contents, 15 October, 2003
... ...In the October 15 issue of the Journal of Clinical Investigation, Michael Moskowitz and colleagues from Harvard Medical School report that fibroblast growth factor-2 (FGF-2) ...plays a critical role in the ability of the brain to make new cells following traumatic brain injury (TBI). The authors also demonstrate that administration of FGF-2 boosts the production of new brain cells and pro...JCI Table of Contents, 1 October, 2003
...... Ischemic heart disease remains the primary cause of morbidity and mortality in the Western world. Current therapeutic strategies are aimed at relieving the ischemia by opening blocked arteries; however, no current therapies can directly protect the heart and ensure ongoing heart function. Faced with this challenge, Walter J. Koch and fellow researchers at Duke University Medical Center, N...JCI Table of Contents, September 15, 2003
... ...A team of researchers, led by Serge Przedborski, at Columbia University in New York, have demonstrated that infusion of D-beta-hydroxybutyrate (D-beta-HB) to mice suffering from Parkinson disease restored impaired brain function and protected against neurodegeneration and motor skill abnormalities. D-beta-HB, already utilized in the treatment of epilepsy, may represent a cheap and easy w...Analysis of the host response to anthrax lethal toxin suggests some current treatment strategies are inappropriate... ...Anthrax, a disease previously primarily relevant to the livestock-management community recently became a wordwide bioterrorism concern. However, human anthrax infection is primarily a result of direct or indirect contact with infected animals or exposure to contaminated animal...JCI Table of Contents, 15 August 2003
... ...In an unusual paradox, asthmatics that are chronically treated with bronchodilating beta-agonist medications such as albuterol, ventolin, and salbutamol may ultimately develop increased sensitivity to airway constriction and experience exacerbation of their condition. A new study by Stephen Liggett and colleagues at the University of Cincinnati in the August 15 issue of the Journal of Cl...JCI table of contents, July 15, 2003
...... In the July 15 issue of The Journal of Clinical Investigation, Ambrose Cheung and colleagues at Dartmouth School of Medicine in New Hampshire, USA, report that salicylic acid (SAL), the major metabolite of aspirin, downregulates two Staphylococcus aureus genes key to this organism's pathogenesis....... Over 100 years have passed since S. aureus was first described as the organism responsi...JCI table of contents, July 1 2003
...... As premature infants often have under-developed lungs, oxygen is administered following birth. One devastating side effect, however, is the development of retinopathy of prematurity (ROP), whereupon oxygen administration to the infant suppresses the expression of essential growth factors that promote the development of retinal blood vessels, resulting in blindness. In the July 1 issue of...JCI table of contents, 16 June 2003
... ...Graves disease, the most common cause of goiter and hyperthyroidism in the United States, came to national attention in the early 1990s when former United States President and First Lady, George and Barbara Bush, developed the condition. The etiology of Graves disease is multifactorial, and nongenetic factors are thought to play an important role. Sandra McLachlan and researchers at Cedar...JCI table of contents, 2 June, 2003
... ...Currently, there is no vaccine available that is able to cure cancer. The success of an antitumor vaccine will depend on its ability to induce robust and sustained tumor-specific immune responses. There is evidence to suggest that antitumor vaccination can induce such responses and even tumor regression. However, to date these regressions have not been long-lasting. Researchers at the Lud...JCI table of contents, May 15, 2003
...... Approximately half of all individuals implanted with pacemakers suffer from sinus node dysfunction. A new study of one such patient reveals a previously unknown mutation in the gene thought to primarily regulate the rhythmicity of the beating heart.... ... TITLE: Pacemaker channel dysfunction in a patient with sinus node disease...... ...Schulze-Bahr, Eric ...Department of Cardiology, Hos...JCI Table of Contents, May 1, 2003
...... Bone marrow or hematopoietic stem cell (HSC) transplantation have recently been used to treat clinically severe autoimmune disease, however they are associated with a high risk of graft rejection or graft-versus-host disease. In contrast, Leonard Harrison and colleagues at the Walter and Eliza Hall Institute of Medical Research, Australia demonstrate that syngeneic transplantation of HSCs...JCI Table of Contents, April 1, 2003
... Expansion of the neointima is a problem in chronic atherosclerosis as well...as in response to acute arterial injury. Smooth muscle cells (SMCs) play a...key role in the pathologic extension of the neointima that ultimately...impinges on the vascular lumen. RAGE, the receptor for advanced glycation...end products, is upregulated at sites of vascular pathology, and its...blockage is beneficia...JCI Table of Contents, March 14, 2003
...... ...... ...David H. Ellison ...Oregon Health Sciences University ...Nephrology/Suite 262 ...3314 SW US Veterans Hospital Rd ...Portland, OR 97201 ...USA ...Phone 1-503-494-8490 ...Fax 1-503-494-5330 ...E-mail: ...... ...... ...... Bone marrow transplantation rev...JCI table of contents, March 3, 2003
... Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient non obese...diabetic mice ...CONTACT: ...Christian Boitard ...INSERM U561 ...Hopital St. Vincent de Paul ...82 Bd Denfert Rochereau ...75014 Paris, ...FRANCE ...Phone 1: 331-4048-8249 ...Fax 1: 331-4048-8352 ...E-mail: ...... ...... ... ...... TABLE OF...JCI table of contents, January 15 2003
Find below two the full Table of Contents for the issue....... ... ... ... HIV Protease Inhibitors Promote Atherosclerotic Lesion Formation Independent...of Dyslipidemia by Increasing CD36-Dependent Cholesteryl Ester Accumulation...in Macrophages ... ...CONTACT: ...Eric Smart ...University of Kentucky ...Department of Physiology ...423 Sanders-Brown ...800 South Limestone ...Lexington, KY 40536 ....JCI Table of Contents, January 2, 2003
...... Cigarettes are addictive, and smoking them causes lung cancer. Of the two..."active ingredients" listed on the packs, scientists had initially assumed...that nicotine was the addictive agent, and tar the carcinogen. Recent...evidence, however, suggests that things are not that simple, and that...nicotine and its derivatives themselves might also promote cancer...development...and progress...JCI table of contents, December 15, 2002
Find below one highlighted articles and the full Table of Contents for...the December 16 issue....... ...... Bone is in a constant state of remodeling, during which osteoclasts remove...old bone (resorption) and osteoblasts form new bone (formation). Calcitonin...is a hormone produced by the thyroid gland and inhibits bone resorption....Following menopause, the rate of bone loss is accelerated, h...JCI Table of Contents, December 2, 2002
**Please mention the Journal of Clinical Investigation as the source of...these articles** ...... Find below two highlighted articles and the full Table of Contents for the...December 2, 2002 issue...... *****************************************************... ...... Angiogenesis (the growth of new blood vessels) requires complex signaling...between multiple cell types, and abnormalities in thes...JCI Table of Contents, November 18, 2002
Find below two highlighted articles and the full Table of Contents for the...November 18, 2002 issue.... ...****************************************************... ... ... ...Most cancer patients are not killed by their primary tumors but succumb to...metastatic disease. The most common human cancers--lung, breast, and...prostate--frequently spread to bone, causing suffering and morbidity through...... ... ... ... Selective parasympathetic innervation of subcutaneous and...intra-abdominal fat - functional implications ... ...CONTACT: ...Felix Kreier ...Netherlands Institute for Brain Research ...Meibergdreef 33, 1105 AZ ...Amsterdam ...THE NETHERLANDS ...Phone: 31-20-566-5500 ...Fax: 31-20-696-1006 ...E-mail: ... ...View the PDF of this article at: ... ... ... ......Please find below two highlighted articles and the full table of contents for the October 1 issue....... **************************************************...... ...... If biologists have learned anything over the past decade, it is how similar all mammals are at the genetic level. Greater than 90% of the genes found in mice are also found in humans, and we even share a significant amount of gene...