Jefferson Lab detector technology aids development of cystic fibrosis therapy
Newport News, Va. To study the structure of the nucleus of the atom, DOE's Thomas Jefferson National Accelerator Facility develops and employs a wide range of cutting-edge detector technologies. Now, Jefferson Lab scientists have used their expertise to build a small animal medical imager that's helping researchers develop a new gene therapy technique for cystic fibrosis.... ..."Our core e...Jefferson scientists find gene expression pattern may predict behavior of leukemia
The expression pattern of certain genes may someday help doctors to diagnose and predict whether or not an individual has an aggressive form of B-cell chronic lymphocytic leukemia (CLL), Jefferson cancer researchers have found. ...Scientists, led by Carlo Croce, M.D., director of Jefferson's Kimmel Cancer Center and professor and chair of microbiology and immunology at Jefferson Medical College...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
MicroRNAs (miRNAs), tiny pieces of genetic material that can serve as stop signs for gene expression and protein synthesis, are thought to be important in the development of cancer. Now, researchers at Jefferson Medical College and the Kimmel Cancer Center of Thomas Jefferson University in Philadelphia have developed a technique that allows them to find which miRNA genes are expressed and how i...Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
Researchers at Jefferson Medical College and Duke University have used gene therapy to help damaged heart cells regain strength and beat normally again in the laboratory. The work takes the scientists one step closer to eventual clinical trials in humans.... Walter Koch, Ph.D., director of the Center for Translational Medicine of the Department of Medicine at Jefferson Medical College of Thomas J...Jefferson researchers uncover biochemical clues to how cells migrate in embryos
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center are gaining a better understanding of the cues that help guide cells to the right places in developing embryos. ...Steven Farber, Ph.D., assistant professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers have found that statins, the grou...Jefferson and Brigham and Women's researchers find blue light important for setting biological clock
Researchers from Brigham and Women's Hospital (BWH) in Boston and Jefferson Medical College have found that the body's natural biological clock is more sensitive to shorter wavelength blue light than it is to the longer wavelength green light, which is needed to see. ...The discovery proves what scientists have suspected over the last decade: a second, non-visual photoreceptor system drives the b...Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
Experiment generates THz radiation 20,000 times brighter than anyone else; breakthrough lights way for application development ...... An experiment conducted with Jefferson Lab's Free-Electron Laser has shown how to make a highly useful form of light -- called terahertz radiation -- 20,000 times brighter than ever before. Jefferson Lab is a Department of Energy laboratory located in Newport News,...Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
Biologists at Jefferson Medical College have shown for the first time in the laboratory that they can convert some human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson's disease. If the researchers can better understand the process and harness this ability, the work may someday lead to new strategies in treating neurodegenerative diseases such...Jefferson scientists show how collagen gene mutation leads to osteoarthritis
Scientists at Jefferson Medical College have shown how a genetic alteration in a type of collagen can lead to osteoarthritis....The researchers, led by Andrzej Fertala, Ph.D., assistant professor of dermatology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, analyzed a mutation in the gene for a type of collagen, collagen II, found in five unrelated families with seve...Jefferson scientists use gene repair technique to change albino mice hairs to black
. Editor's Note: This information is embargoed for release on Dec. 28, 1999, at 3 p.m. EST. . The technique may someday be used in treating inherited disease.. . Researchers at Jefferson Medical College have used an innovative "gene repair" technique to genetically change white albino mice hairs to black. The technique has not only turned hairs black, but has showed that such changes are stab...Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
. .Glucosidase inhibitors may have a future as broad-based hepatitis drugs. Researchers at Jefferson Medical College may have found a promising drug.against the hepatitis C virus (HCV). While they are quick to point out that the.drug, N-nonyl-DNJ, stopped only a surrogate virus - and not the actual HCV -.from reproducing in the labora...Jefferson scientists propose mechanism to control the body's red blood cell and platelet production
. The new work may provide essential background for new therapeutic strategies in.red blood cell and platelet disorders . . Researchers at Jefferson Medical College have uncovered a potential.switch that helps control the manufacture of red blood cells and blood-clotting.platelets. By better understanding how the body keeps tight reins on this.process, the scientists hope to someday thera...... ............... For many women under 40 with breast cancer, surgery to remove the...cancerous lump and accompanying radiation seem the best way to get rid of the...disease and preserve the natural breast. But for women who carry a damaged...version of BRCA1 or BRCA2, genes predisposing them to breast cancer, such...treatment may not be enough. Researchers at Jefferson Medical College...... The work could lead to laboratory production of blood cells for transfusions and...to clinical innovations in bone marrow transplants and gene therapy ... ............ Scientists at Jefferson Medical College have found a way to isolate...hard-to-find hematopoietic stem cells. The researchers, in identifying a...chemical beacon-- a protein marker-- on the cell, believe the new work w...Jefferson scientist hopes to answer the question, 'Why is it so hard to quit smoking?'
. . . Some people would never think of trying to quit smoking. The daily.routine of reaching for a cigarette after morning coffee is too ingrained..Grabbing a smoke after lunch, or after a hard day at the office -- there's.nothing quite like a cool long drag, and the expected nicotine buzz. You can.quit anytime you like.. . For many, however, quitting smoking is next to impossible....Jefferson scientists create first transgenic mouse model of hepatitis B-based liver disease
. . . The work holds promise for understanding the mechanisms of disease and for drug.discovery . Researchers at Jefferson Medical College have developed the first mouse.model of chronic liver disease caused by hepatitis B virus (HBV), which promises.to accelerate the discovery of drugs against the disease. Such a model may.provide a better understand.... Those receiving prenatal care and antiviral treatments already were more likely.to get AZT . . How well are medical advances translated into the community practice? In.the case of HIV-infected pregnant women, where they get their care may matter.the most.. . In 1994, researchers were stunned when they found that the anti-HIV drug.AZT, taken during the second and third trimester,...Jefferson scientists further develop gene repair technique
. Researchers, in creating new gene repair molecules, are edging closer to.potential applications . . Molecular geneticists at Jefferson Medical College are inching closer to.using a novel gene repair technique to treat diseases such as cystic fibrosis.and sickle cell anemia. While the work remains in the early stages, the.scientists are hopeful that their technique will eventually be abl...Jefferson scientists detail mechanisms of programmed cell death
. By detailing the precise molecular pathways of apoptosis, or programmed.cell death, scientists at Jefferson Medical College hope to someday develop new.drugs against cancer, Alzheimer's disease and Parkinson's disease. . . In the June 10 issue of the journal Nature, Emad Alnemri, Ph.D.,.associate professor of microbiology and immunology at Thomas Jefferson.University in Philadelph...Jefferson Scientists Find Further Proof Of Damage To The FHIT Gene In Breast Cancers
.Scientists at Thomas Jefferson University in Philadelphia, the.University Hospital of Iceland in Reykjavik, and the National Human Genome.Research Institute in Bethesda have found further evidence linking damage to the.tumor suppressor gene FHIT to the development of breast cancer. . . In a study of 92 Icelandic women, the researchers, led by Kay Huebner,.Ph.D., professor of microbiolog...Jefferson Scientists Find Link Between Learning And Preventing Alzheimer's
. A new study suggests that a stimulating, learning environment early in.life might actually help ward off neurodegenerative diseases later. The findings.indicate that nurture may be more influential than nature when it comes to the.brain's resilience against injury.. . Researchers at Jefferson Medical College of Thomas Jefferson University.in Philadelphia and at the University of.... Can the AIDS virus still be dangerous even if it can't be detected in.the body?. . Apparently so. Scientists at Jefferson Medical College have found that.the AIDS virus, HIV, is still present in an inactive 'latent'--and potentially.infectious--form in the semen of infected men undergoing treatment with.powerful, new antiretroviral therapies, even if no measurable virus can be.de...Jefferson Scientists Use Gene Repair Technique To Change Albino Mice Cells To Black
. Researchers at Jefferson Medical College have used an innovative 'gene.repair' technique in the laboratory to genetically change white albino mice.color-producing cells to black. Not only have the cells turned black, but the.scientists showed for the first time that such changes are both permanent and.can be passed to offspring. . . The work holds promise as a potential treatment...Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy
. Scientists at Jefferson Medical College believe they have taken the next.step toward gene therapy trials for lung cancer. . They have demonstrated for the first time in laboratory animals that a.normally protective anticancer gene, pRb2/p130, can actually block tumors from.growing. A damaged version of the gene, termed a "tumor suppressor," has been.implicated in several cancers,...Jefferson Researchers Provide Leads To Potential Parkinson's Treatment
. A Natural Substance In The Cell Membrane May Either Protect Or Stimulate Brain.Cell Activity . A naturally occurring substance in the cell's membrane may improve.symptoms in Parkinson's disease patients and perhaps even help slow down the.progression of Parkinson's, according to studies by researchers at Jefferson.Medical College of Thomas Jefferson University in Philadelphia. . Jay S............. Scientists at Jefferson Medical College of Thomas Jefferson University...in Philadelphia appear to have an important clue to the workings of a gene that...normally protects against cancer. Ultimately, by understanding how both the...normal and the damaged gene work, scientists may be able to find ways to...interfere with the development of cancer.... Charles Brenner, Ph....Jefferson Scientists Devise Way To Treat Animals Chronically Infected With Hepatitis B
............ Scientists at Jefferson Medical College may have helped devise a new way...to fight the hepatitis B virus (HBV). Timothy Block, Ph.D., professor of...biochemistry and molecular pharmacology and medicine at Thomas Jefferson...University in Philadelphia, and his colleagues at several institutions have...found that by interfering with a specific step in the life cycle of the...w...Jefferson Scientists Link Some Cases Of Scleroderma To Damage From Lingering Fetal Cells
. . Researchers hope that the work will ultimately lead to. new treatments. . In some women, scleroderma, a potentially life-threatening. skin disease that can affect joints and internal organs, may. be linked to long-dormant fetal cells stirring an immune. system reaction. . Sergio Jimenez, M.D., Dorrance H. Hamilton Professor of. Medicine and professor of biochemistry...Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
. . . . .Researchers at Jefferson Medical College are for the first time attempting to use gene therapy to treat Canavan disease, a rare, fatal metabolic brain disorder. . .A team of neurosurgeons are treating a four-year-old Illinois girl at Thomas Jefferson University Hospital, Thomas Jefferson University, Philadelphia. The group includes Andrew Freese, M.D., Ph.D., associate professor of...Jefferson Researchers Find Correlation Between Gene And Endometrial Cancer
Researchers at Jefferson Medical College have found that. the less a particular "protective" gene is present. in endometrial cancer cells, the more aggressive the disease. will be, and the greater the likelihood the woman will die. from the disease. The finding may eventually lead to a test. that can predict disease severity and help guide treatment. . Antonio Giordano, M.D.,...Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
...Embargoed until Tuesday, February 17, 1998 at 12:30 p.m. EST....Dr. Jouni Uitto will present study results at the 1998 American Association for...the Advancement of Science (AAAS) annual meeting at the Pennsylvania Convention...Center, Philadelphia, Pa.... ...Jefferson Researchers First to Create Genetically Engineered Mouse to Study...Photoaging ...Transgenic mouse leading to better understa...Jefferson Scientists Develop Botulism Vaccine
Molecular biologists at Thomas Jefferson University,. Philadelphia, have created an oral vaccine against botulism.. The researchers believe that such a vaccine could be used as. a prototype in developing future vaccines for other diseases. such as diphtheria, whooping cough and tetanus. Eventually,. they say, their discovery may lead to a range of oral. vaccines that could be i...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
. . The Finding May Lead To. Improved Therapeutics And Understanding Of Both Normal And. Cancer Development . Cancer geneticists at the. Kimmel Cancer Center of Thomas Jefferson University,. Philadelphia, studying specially bred "knockout". mice, have found that two genes that normally protect against. cancer may play a greater role than previously suspected in. female de...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
.Findings could. lead to improvements in cancer diagnostics. Cancer researchers led. by Antonio Giordano, M.D., Ph.D., associate professor of. pathology, anatomy and cell biology at Jefferson Medical. College, have for the first time found direct evidence of a. potential mechanism of a monkey virus in the development of. mesothelioma, a rare connective-tissue cancer commonly....