St. Jude researchers use DNA chips to determine how leukemia cells respond to different drugs
(MEMPHIS, TENN.April 21,2003) Investigators at St. Jude Childrens Research Hospital have discovered numerous genes that alter their level of activity in characteristic patterns in response to specific chemotherapy treatments. The genes were identified in the leukemia cells of children undergoing chemotherapy for acute lymphoblastic leukemia (ALL). ...The researchers say this finding is a signifi...St. Jude researchers create image of enzyme that orchestrates natural genetic engineering
New insight into the structure of a virus enzyme that orchestrates a natural type of genetic engineering in bacteria provides important clues into how similar enzymes control the same process in human cells during DNA replication and repair. These findings from investigators at St. Jude Children's Research Hospital are published in the April issue of ...The St. Jude researchers developed a 3-D i...St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules
Investigators at St. Jude Children's Research Hospital have demonstrated for the first time that--contrary to the long-held belief among scientists that proteins must maintain a rigid structure in order to perform an assigned task--many proteins actually exploit disorderliness in their structure to perform a variety of different jobs. The findings of this research appear in the current, online is...St. Jude/Mayo Clinic study finds direct link between CBP gene and lymphoma
(MEMPHIS, TENN.--Feb. 24, 2004) Inactivation of the gene CBP in certain immature white blood cells of mice causes lymphoma, a type of cancer also found in humans. The cancer is accompanied by changes in the expression of specific genes associated with development of the disease. These findings, from researchers at St. Jude Children's Research Hospital and the Mayo Clinic, are published in the Feb...St. Jude ranked among top 500 supercomputer centers
MEMPHIS, TENN.--December 22, 2003 - St. Jude Children's Research Hospital has joined the ranks of world-class supercomputer users around the world with the installation of an IBM computer system that can perform more than 600 billion operations per second. ...The supercomputer, an IBM eServer® BladeCenter™, which is equivalent to 280 servers working at once, puts St. Jude in 251st plac...St. Jude researchers reverse blood disease using genetically modified stem cells
(MEMPHIS, TENN.--May 1, 2003) Researchers at St. Jude Children's Research Hospital have overcome two major technical obstacles that currently limit the success of gene therapy for human red blood cell diseases such as beta-thalassemia and sickle cell disease. ...The St. Jude team overcame the obstacle posed by the large number of defective hematopoietic stems cells (HSCs) producing faulty red bl...St. Jude develops vaccine against potential pandemic influenza virus H5N1 using reverse genetics
(MEMPHIS, TENN.--April 2, 2003) Scientists at St. Jude Children's Research Hospital announced today the development of a vaccine against H5N1, a new lethal influenza virus that triggered the World Health Organization (WHO) to declare a pandemic alert in February 2003. ... ...The virus appeared in birds in Hong Kong late last year and subsequently killed one of two infected people with rapidly pro...St. Jude researchers decipher structure, activity of enzyme key to biochemical pathways of life
(MEMPHIS, TENN.-- March 26) Scientists at St. Jude Children's Research Hospital have discovered how a single enzyme called E1 performs a rapid-fire, three-part chemical makeover of a protein that helps control some of the most fundamental biochemical processes of the human cell. The enzyme uses two different parts of its own structure to juggle four different molecules as it completes three diffe...St. Jude researchers show that the Six3 gene is vital in the creation of the brains complexity
(MEMPHIS, TENN.Jan. 31, 2003) Researchers at St. Jude Childrens Research Hospital have discovered a critical, early step in the growing vertebrate embryo that is required for the proper development of a major part of what is often called the most complex structure in the universethe human brain. ...That vital step is orchestrated by the product of a single gene called Six3, which guides the form...St. Jude researchers discover genetic reason why some patients resist HIV therapy
... Study sheds light on how cells evade anti-HIV drugs in absence of drug-resistant...virus ... .....................MEMPHIS, TENN, August 30, 1999 -- The gene MRP4 appears to help T cells, key...components of the human immune system, "pump out" certain anti-HIV drugs and may...allow the development of drug-resistant strains of HIV, report a team of St....Jude Children's Research Hospital scie...