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Bacterial Toxin Surprises Scientists

...y power of certain toxins, but on diseases like cystic fibrosis that result from defects in natural membrane channels. "If we could understand how this protein works, we might understand more about how proteins are normally moved across and inserted into membranes...

Gene-Altered Mouse May Provide New Insights To Parkinson's Disease, Substance Abuse And Schizophrenia

...e synapse longer, it prolongs theneurotransmission like cocaine or amphetamine would, even though there isvery little of it. The researchers realized this very dopamine-conservation strategy couldbe used to treat Parkinson's patients. Because Parkinson's patients makevery little dopamine, the trick is to...

Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs

... implications in drug design. "Topoisomerase is like several enzymes in one because its various conformations are so different," Dr. Wang said. "Each one is a potential drug target." Many anticancer drugs, initially recognized for their ability to kill...

New Cancer Switch Discovered By Duke Medical Center Pharmacologists

...ctural features that allow it to fit parts of cABL like a key fits a lock. "This is the first time we've been able to open a window on what activates normal cABL," said Pendergast. "People have been looking for this molecule, or a molecule with these characteristics, for over a decade." In their experimen...

Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"

...unity. The scientists found that the syndrome was like Huntington's disease inthat it was attributed to genes that acquire excess CAG nucleotide sequences. Although the scientists do not know what the roles of the proteins producedby Haw River or any of the triplet repeat diseases are, "Our hypothesisis...

Researchers Pinpoint Site For Petit Mal Seizures In Brain

...see in sleep. In a sense, the petit mal seizure is like a momentary lapse into sleep." To determine where in the neural signaling process the defect lies, Caddick measured the function of GABAb receptors at the junction between nerve cells where signals are transmitted from one nerve to the next. She show...

New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics

...s. Lipid A servesas the outermost coat of bacteria like E. coli. Thus, LpxA is "essentialfor bacterial growth as well as the maintenance of the permeability barrierfunction of the outer membrane," the scientists said. Like all protein enzymes, LpxA consists of a long chain of amino acidsthat folds...

Dating A Caveman

...ina. The dating of cave limestones ("speleothems") like those of Zhoukoudian uses principles of chemistry ... small amount of U-234 and Th-230 found in samples like the Zhoukoudian material. But by upgrading and calibration of instruments pioneered by scientists at...

Children Become Gorillas In VR Zoo

... The virtual gorillas also have to look and behave like realgorillas. Using videos, anthropomorphic data ...n annoyed cough. "People always expect them to be like monkeys, who do run around,"said Lori Perkins, conservation biologist with the zoo's ConservationAct...

From Corn Rootworms To Art, Cornell's Reactor Is At The Core

...s the photographic image on film. The result looks like an X-ray, but it can reveal things X-rays cannot. An example: a toy plastic gun sealed in a 1-inch-thick lead box. The neutron radiograph shows details inside the gun, even its spring mechanism, but X-rays could not even penetrate the lead box. "N...

Duke Researchers Find Second Gene Linked To Blood Vessel Disorder

...ren't rare. Everyone has these genes, and we would like to know howthey operate normally so we can underst...y with the disease, it is very important. We would like tobe able to offer some hope to these families." The protein encoded by the ALK1 gene appears to b...

Mutate Or Die: New Polymerase Gives Desperate Yeast An Option

..., the type often seen in cancer cells or oncogenes like p53 or ras in humans. His laboratoryis now searching for counterparts in humans to the two genes that code for zeta, and scientist Peter Gibbs has found onewhose sequence bears the markings of a zeta polymerase. If zeta is found in humans and wor...

Cornell Researchers Precisely Date Wood From Ancient Tomb In Turkey

...t's ultimate goal is to connect early chronologies like the one described in Nature to the present, to cr...an and Greek civilizations; event-based histories, like the Trojan War and the Exodus; and social evolution, like the Neolithic Revolution and the formation...

Southern Pine Beetle Reaching Outbreak Levels In North Florida

...les cannot survive, regardless ofcontrol measures, like pesticides. The beetles also carry and introduceinto trees the deadly blue stain fungi. Under normal conditions, thebeetles dine only on stressed or damaged pines, but during outbreaks theyattack healthy trees. Females may live a month and lay 160 eg...

Nutrition Study Reshapes Strategies For Athletes

...k, and something else to think about, she said.But like other athletes involved in intense competition, they are lookingfor an edge. And some of the women feel Houtkooper has given them one. Houtkooper said non-athletes also can benefit from her research. "What werecommend to athletes are the same kinds ...

Humble Pocket Gophers Shed Light On The Genetic Fortitude Of Cheetahs

...at a price if you have low genetic variation. It's like having lots of clones of yourself." If animals within a population are similar to each other immunologically, Sanjayan adds, "That doesn't bode well for disease resistance. If a new disease arises, either they'll all be resistant or they'll all be wi...

Researchers Find Possible New Route to Making Cancer Cells Vulnerable

...scientists believed the anti-rejection drugs acted like sludgein a gas tank, clogging the pump mechanism. ...ly halt the cellular pump by removinga vital part, like a valve from a car's fuel pump. "Cyclosporin-related drugs are now being tested for their ability t...

Bee Sting Treatment Should Emphasize Speed, Not Method Of Removal

... a person is to have dangerouswhole-body responses like constriction of breathing or a drop in blood pressure. Additionally, victims of bee stings should leave the area where they arestung since the attack may have been the response of a bee defending itsnest, Visscher said. Once a bee stings, it emits a...

Bark Beetle Infestation Spurs Multifaceted Study

...stumps." An understanding of what the forest was like before European settlement,during logging and how it grew back afterwards, could help environmentalistsand resource managers plan the future of these forests which surround someof the last pristine lakes in the U.S....

Virginia Tech Researchers Receive Patent For Rapid Virus Detection Technology

...Falkinham. Further, the bacterial viruses act more like otherviruses, such as the ones that cause human diarrheal infections,than do cells of E. coli , he says. "Numbers of E.coli viruses may be better indicators of human health riskof drinking and recreational waters than numbers of bacteria." The enz...

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(Date:10/22/2014)... Lexington, Kentucky (PRWEB) October 22, 2014 ... an agreement that will change the current location of ... Road to South Limestone across from the University of ... be a state-of-the-art ambulatory care center, owned and operated ... meet the orthopaedic needs of children and their families ...
(Date:10/22/2014)... Pass, OR (PRWEB) October 22, 2014 ... Southern California’s fresh water supply runs dangerously low, Southern ... change. Southern Oregon’s rivers, despite the lowest mountain snow ... even in late summer and early autumn.* That was ... authors of the new book “Hiking Southern Oregon,” during ...
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(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 ... may be showing a genetic propensity for obesity as toddlers, ... been linked to increased body fat, but the same genes ... the researchers said. At 1 year, kids with these ... 3, however, these genes were linked to excessive weight gain, ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
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