Tag: "livers" at biology news

Purdue Researchers Prod Plants To Clean Up Pollution

...nant. Cadmium recently was found at high levels in livers of British sheep grazing on a pasture fertilized f...ety of Animal Science, cadmium levels in the sheep livers were high enough to cause concern but probably not high enough to cause serious health problems for ...

Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders

...ing the genetically-altered RCRs directly into the livers ofmice (through the portal vein), the researchers reported a 100-fold higherexpression of the gene compared with mice who received injections of naked DNA. The more DNA that was incorporated into the RCR complex, the higher the geneexpression was -- ...

Gene Therapy Enables Transplantation Without Immunosuppressive Drugs

... ina rodent model, have succeeded in transplanting livers without the need forimmunosuppressive drugs. In a scientific first, a gene therapy strategy was usedto alter the donor liver prior to surgery so that the immune system of therecipient became permanently tolerant of the new organ. The new findings are...

University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth

...tliver regeneration in rats that had part of their livers removed. The animalssuffered no toxic side effects. Researchers at UPCI are at the forefront of experimental work usingvitamins A, D and K to prevent and treat various forms of cancer in laboratoryanimals and in clinical trials with patients...

Baker's Yeast Causes Chemical Reactions And Sweet Smelling Labs

...ly use comefrom inconvenient sources such as human livers and disease-causingbacteria. They also need a helper molecule, or co-factor, to perform areaction. Also, in current reactions, chemists use a chemical reagent as acatalyst, but those reagents are toxic and explosive. "We want to solve those p...

Cedars-Sinai Scientist Finds Malignancy Gene In Tumor Cells

...eaction (PCR)band kept appearing in specimens from livers from patients with advancedcirrhosis or liver cancer. Further exploration led to the conclusion that it wasa gene associated with malignancy. In her paper, Dr. Ljubimova wrote,"Analysis of 30 liver and five brain disease cases for MAG expression ha...

Idun Pharmaceuticals Identifies Cell Type And Molecular Pathway Involved In TransplantationRelated Liver Damage

... added acompound known to inhibit caspase-3 in rat livers at various points of the liverpreservation process. This compound, IDN-1965, is being developed by Idun. Thedata show that addition of IDN-1965 reduced apoptosis by 63 percent, as measuredby the TUNEL assay. "This research demonstrates that apopto...

Exotic Species, Migratory Birds, Sea Level Rise, Wetlands, And Contaminants...USGS Scientists Discuss Innovative Chesapeake Bay Restoration Studies

...ay in spring 1995, and their intestinal tracts and livers were analyzed for 13 metals including copper, lead, and zinc and for an acidic ash characteristic of sediment. Sediment samples also were analyzed for the same metals. The results suggest that comparative evaluation of sediment contamination levels a...

Beer Inhibits Action Of Carcinogenic Mutagens

... suppressed DNA-carcinogen adduct formation in the livers of laboratory mice, according to Arimoto. "This adduct formation is a 'biomarker'for the cancer-causing action of a compound," she notes. Red and white wines, brandy and Japanese sake also were effective ininhibiting mutagens, the report sta...

Duke Scientists Engineer 'Stealth Virus' To Deliver Genes

...he blue marker, the modified viruspersisted in the livers of the treated animals for greater than two months. Incontrast, the virus was essentially eliminated within three weeks from thelivers of animals in a control experiment using an unmodified adenovirus vector. "Our modification of the adenovir...

New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection

...e production ofcytokines or to deliver them to the livers of infected patients in sufficientquantities or in enough time for elimination. This work provides fundamental newinsights into the immunological mechanisms of infection control." The study was funded by the National Institutes of Health....

Immune Response To Hepatitis B Spares Liver Cells

...t of hepatitis B virus DNA in the chimps' bloodand livers peaked eight weeks after infection. The HBV DNA levels then rapidlydecreased - by week 12 more than 90 percent of the HBV DNA had been eliminated. Surprisingly, the dramatic reduction in HBV DNA occurred before the chimps'immune systems counter-atta...

Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover

...e marrow-derivedhepatocytes by transplanting whole livers from one rat species without aspecific tissue mark...xperimental injury, thetransplanted L21-6-negative livers showed evidence of repair with L21-6-positivecells, suggesting they came from a source outside the l...

Duke scientists reverse a rare form of muscular dystrophy in mice using gene therapy

...e mice that received the modifiedGAA gene in their livers subsequently had reduced accumulation of glycogen inmuscles throughout the body. "The heart and diaphragm muscles appeared to be especially responsive tothe treatment," said Amalfitano. "This is significant because failure of theheart or resp...

Study: breath test effective in showing patients who should get less cancer drug

...arious solid tumors -- sometimes kill people whose livers cannot clear the drug at the normal rate. Doctors ...lt of the treatment." Conversely, patients whose livers clear a given chemotherapy rapidly may not get a dose strong enough to be effective against their ca...

Can heavy alcohol use lead to some kinds of cancer?

...bility to remove normal blood cholesterol in their livers often died before they reached 30 years of age. He added: "Our findings open a new area, both for screening and preventive research, with respect to gastrointestinal tract cancer. I hope we will be able to one day use our findings about microbially...

Researchers zero in on first drug that may be helpful in treating common liver disease

...rug to obese, insulin resistant mice who had fatty livers and studied them in comparison with similar mice w...f tumor necrosis factor alpha (TNF alpha) in their livers than those who had not. TNF alpha is a protein produced by the body during inflammation. It also pro...

K-State professor develops vaccine to stop liver abscess in cattle

...f is less expensive for consumers. About 5 million livers are condemned each year because of liver abscess. With livers selling at an average of $5 each, five million condemned livers means a $15 to $20 million loss to t...

Antibiotics, yogurt seen as potential treatment for common liver disorder

...archers found that all of the obese mice had fatty livers and, when they aged, they produced roughly five times more ethanol than their lean counterparts. In a third experiment, Diehl and her colleagues significantly reduced the amount of alcohol produced in obese mice by giving them oral antibiotics to k...

Carolina scientists the first to identify and purify liver stem cells

...f the liver. In addition, according to Reid, whole livers used for organ transplantation are exquisitely sensitive to a lack of oxygen, or ischemia, especially when at body temperature (warm ischemia). This means they must come from the 1% of donors who have undergone brain death but not heart arrest. "By ...

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