Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...inds other proteins critical to glucose and oxygen metabolism in the brain.And the larger the repeat region, the tighter they bind." Authors of the study are from the same team that discovered the major genelinked to Alzheimer's disease. In many ways, "this finding may be morepivotal than our earlier work," sa...Two Long-sought Diabetes Gene Found
...thinking of diabetes purely as a defect in glucose metabolism and starting thinking of it as possibly a defect in gene expression," said Bell. "That makes diabetes a more complicated disorder, but it also opens up new ways of treating it. "The discovery of these genes means that we have to place more emphasis o...Altered Genes, Altered Metabolism--Longer Life?
...gene, named daf-2, which regulates glucose (sugar) metabolism in a tinyworm, Caenorhabditis elegans, may also af... Hospitalspeculates that a downshifting of glucose metabolism in times of stress helpsthe worm live longer. Dr. David Finkelstein, of NIA's Biology of Aging progr...Vitamin C Deficit Linked To Skin Disease
...e low values include dietary insufficiency, faulty metabolism of thevitamin, impaired absorption or increased turnover of the vitamin. In earlier experiments the researchers found that adding vitamin C to culturesof chicken liver cells prevented the light-sensitive porphyrins fromaccumulating in the cells. In ...Human Breast Milk Contains Obesity Hormone
...one that appears to play an important role in body metabolism and obesity, has been found for the first time in ...d adjunct assistant professor of endocrinology and metabolism at the Indiana University School of Medicine, is interested in the role of leptin during transitiona...Infants, Toddlers Should Not Restrict Fat Intake, Experts Say
...y. Bruce Watkins, professor of lipid chemistry and metabolism at Purdue University, and Bernhard Hennig, professor of cell nutrition at the University of Kentucky, say that children under age 5 -- especially infants -- are getting too little fat in their diets. They are suggesting new dietary recommendations fo......t is the single most critical knownelement in iron metabolism has been identified and characterized by scientistsat the University at Buffalo and Children's Hospital in Boston, which isaffiliated with Harvard University. The first protein to be identified as essential for normal intestinaliron absorpti...B-Vitamins Lower Homocysteine Levels In The Blood; May Reduce Vessel Damage In Stroke Patients
...are homocysteine, a natural byproduct of thebody's metabolism of protein and other nutrients, and thrombomodulin...High levels of homocysteine, which result from the metabolism of theamnio acid methionine, are known from laboratory studies to damage bloodvessels. Scien...Low B Vitamin Levels Common In Many People Linked To Increased Heart Disease, Stroke Risk
...m. Homocysteine, a natural byproduct of the body's metabolism of meat and dairy foods, has been shown in earlier research to damage the lining of blood vessels. Low levels of vitamin B-6 can lead to elevations in homocysteine.Regarding the surprising finding about normal levels of homocysteine in people with l......amino acid homocysteine, a natural byproduct ofthe metabolism of food, have been associated with increased risk for heartdisease, stroke and atherosclerosis in blood vessels of the limbs. "Thus, blood homocysteine may be a risk factor for atherosclerosis in asimilar fashion as smoking, high blood pressure ...Genetics May Explain Much Age-Related Hearing Loss
...d throughout the body asby-products of normal cell metabolism can cause extensive damage to livingtissues, including the sensory hair cells in the inner ear, if they are notneutralized by antioxidant enzymes," McFadden said. "We think that SODdeficiencies may increase cochlear vulnerability to environmental in...Lactose-Intolerant People Should Drink More Milk, Expert Says
...ducts extremely well." Research studies on calcium metabolism have shown the effectiveness of this form of treatment, Savaiano says. "We've found that if you do controlled clinical blind trials, where people don't know what they are consuming, and you take out that placebo effect, you can give subjects a glass ...Studies Underscore Link Between Nutrition And Nonmelanoma Skin Cancers
...adical molecules produced as a byproduct of normal metabolism and byultraviolet light have been shown to be potentially important in protectingagainst skin cancers. "Some animal and epidemiologic studies have shown that a higher intakeof Vitamin C can reduce the development of nonmelanoma skin cancer," ...Pharmacogenesis: Postgenomic Drug Discovery Through Developmental Biology
...ntral nervoussystem, hematopoeisis, diabetes, bone metabolism and oncology. For more information and a detailed schedule, please visit our website at: http://www.noonanrusso.com To receive abstracts, or to arrange interviews, please call Renee Solano,Noonan/Russo Communications, 212-696-4455, x227 or re...Nitrate Reductase: A Magical Enzyme?
...efficient enzyme with an important job in nitrogen metabolism in plants,according to Campbell. The problem is--plants don't need much nitrate reductaseto get their job done and so nature doesn't provide enough of the enzyme forscientists to do the studies they need for determining just how the enzymefunctions a...Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat
...abolized or used by the body. Cholesterol metabolism has many steps. First, the liver turns foodingested into fatty acids, carbohydrates, alcohol and some cholesterol into verylow-density lipoprotein (VLDL), the largest type of lipoprotein. VLDL istransported through the bloodstream to the body's tis......6 (5) - May 98) the effects on starch metabolism exerted if the expression of this gene is inhibited in transgenic potato plants using antisense technology. A major observation made is the reduction of the phosphate monoester content of the starch synthesized in the transg...COGA Genome Scan Suggests Linkage On Chromosomes 1,2,4, And 7
...r are known to encode isozymes that accelerate the metabolism of ethanol to acetaldehyde, creating the aversive "flushing reaction" that prevents many Asians from regular or heavy drinking. Evidence for an additional protective chromosome 4 locus in COGA's predominantly Caucasian sample, taken with that from an...Gene May Hold Key To Treating Life-Threatening Cholesterol
...m a study, in which a gene that speeds cholesterol metabolism was turned off, will help scientists develop bette...ochemically design hormonal ligands that can speed metabolism and reduce dietary cholesterol levels in humans. Screening for mutations in LXR-alpha also may help ...Gene Variant Found That Can Help Protect Against Nicotine Addiction
...oup were much more likely tohave impaired nicotine metabolism (and to have one null allele for CYP2A6). Thus, those with a null allele had been "protected" against nicotine addictioncompared with individuals with the normal or wild type alleles. In addition,among a group of people who do smoke regularly, those ...