Tag: "mice" at biology news
Gene-Altered Mouse May Provide New Insights To Parkinson's Disease, Substance Abuse And Schizophrenia
...cell biology at Duke,said initial studies with the mice
already have yielded surprising insightsthat chall...hetamine drugs derived from studying the"knockout" mice
should yield new strategies for treating amphetamineaddiction, Caron said. "Much of what we know ab...
Researchers Pinpoint Site For Petit Mal Seizures In Brain
...Previously, the Duke researchers had reported that mice
with petit mal seizures have an overabundance of a...at inhibit GABAb receptors control seizures in the mice
genetically prone to petit mal epilepsy. The new information will allow the research team to pinpoin...
Tumor Suppressor Gene Located In Liver Cancer Cells
...o researchers because it could help to explain why mice
appear to be more prone to liver tumor formation t... is especially unusual, because it is imprinted in mice
but not in humans. Lacking the back-up that humans have in case one copy malfunctions, mice
Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...University Medical Center have identifieda gene in mice
that, when malfunctioning, causes a joint-destroyi...nflammatory autoimmune response. By comparingtheir mice
with other animals that had similar clinical signs, the researchershypothesized the animals were pro...
Florida Researchers Discover Gene For Fatal Childhood Disease
... offer genetic therapy for it." People and mice
who have Chediak-Higashi syndrome are much moresus...e said. Meanwhile, researchers discovered that mice
with Chediak-Higashisyndrome are protected against some forms of autoimmune disease, especiallythe c...
Protein Glitch May Be Early Problem In Inherited Alzheimer's
...ael Lee studied presenilin in cell cultures and in mice
that contained copies of the human presenilin gene...ease. Hopkins researchers currently are looking at mice
in which the gene for presenilin is knocked out so that presenilin's function may be revealed by its...
A Genetic Skeleton Key
...s." Many cancer-causing genesalready identified in mice
and otherlaboratory animals are thought tohave ana... that we think of humans asmore closely related to mice
than tochickens," Pevzner notes. Even when the starting point ofthe reconstruction was target materi...
Pinpoint Gene Control Holds Promise For Nervous System Studies
...of the technology: permanently turning on in adult mice
the genefor nerve growth factor (NGF), a substance...ence that kept the genes turned off. Then, whenthe mice
were several months old, scientists injected a viralvector that shuttled into the cells an enzyme th...
ORNL Mice Helping Researchers Isolate, Identify Causes Of Cancer
...e cancer." Included in ORNL's inventory of 120,000 mice
are 1,000 strains, some ofwhich were originally br...st developed, scientists didn't know thereason the mice
developed leukemia. Now, however, Justice and colleaguesknow that the mice
get cancer because of mur...
ORNL Finds Common Genetic Cause For Epilepsy, Migraine
...graine, ataxia andepilepsy, meaning that tottering mice
-- aptly named for their lack ofmuscle control -- represent mouse models for both diseases. These models,developed with the help of a human chromosome 19 map from the Human GenomeCenter at Lawrence Livermore National Laboratory (LLNL), are likely to ...
Researchers Find Production Point Of Key Protein In Fragile X Syndrome
...mal nerve cells resulted fromstudies of transgenic mice
that cannot produce the fragile X protein. Previou...versity in the Netherlandsdeveloped the transgenic mice
for the project....
Summer Science: Firefly Babies Advertise Their Bitter Taste, UD Researchers Say
...ted theaposematic display theory on ordinary house mice
raised in a laboratory. Butfirst, the UD researchers needed to find out whether mice
think firefly larvaetaste bad. In previous laboratory studies, vertebrate predators have consistentl...
Resistance To Leptin Contributes To Obesity
... regulateits fat stores, contributes to obesity in mice
according to the firstformal study of leptin intol...cans, the researchers note. "We knew obese mice
and humans generally have high levels of leptinin their blood, which suggested that the protein was ...
Huntington's Disease Findings Pave Way For Potential Cure
... Columbia researchers found. Usingnew "transgenic" mice
developed by Dr. Bates to contain a disease-causin...e. The NII werepresent in the brain cell nuclei of mice
with symptoms very similar to HD andabsent in non-transgenic control mice. "This radically...
Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
...Ph.D. and Tina Bocker, M.D., report that female mice
that lack a pair of tumor-suppressor genes, p53...R. et al., Cell, 74:1027, 1993). Knockout mice
lack a working gene or genes and are used as models to study the effects of cancer gene altera...
Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections
... lethal to mice. But when the scientists infected mice
with Candida strains with both pathways knocked out, the mice
survived and did not succumb to the infection. Based on Dr. Fink's work, other scientists at Purdue ...
OHSU Scientists Discover Mice Lacking Dopamine Receptor Are Supersensitive To Alcohol, Cocaine And Methamphetamine
...Cell and detail the increasedlocomotor activity of mice
who lack the D4 receptor. "Branching nerve cells ...ne, methamphetamine and opiates. "We examined mice
that were genetically engineered to lack the D4dopaminereceptor to investigate the role of this rece...
Smoking Mice Lead To Emphysema Breakthrough
...s emphysema, Shapiro and otherscreated a strain of mice
that lacked the enzyme. He calls them "mighty mice... it down." Researchers put both the mighty mice
and normal mice
into smokingchambers twice a day, six days a week. The mice
didn't actually have cig...
New Form Of Gene Therapy Holds Promise For The Future
...en needed. They have developed a system in mice
in which the level of a geneticallyengineered protein responds to inflammatory signals produced by the micethemselves. This method of gene therapy, described in the October issue ofNature Biotechnology, may have great potential for treating chronic r...
Study Shows Hereditary Legacy Of Radiation Exposure
...ose exposed. In the past, researchers have shownin mice
that some effects -- in the form of genetic mutati...dreds of thousandsof mice. Hers uses only about 75 mice
at a time. According to Wiley, whatis new about her findings is that she saw the radiation effects i...
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