Tag: "modify" at biology news

Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival

...death. That could help physicians determine how to modify therapies to improve chances of success in the future. The findings were based on a retrospective study of samples taken from osteosarcoma tumors of children treated at St. Jude during a 20-year period. Telomerase is an enzyme that helps cancer cell...

Poplar DNA code cracked -- a step in combating global warming?

... thorough genetic knowledge enables researchers to modify trees genetically for the benefit of humankind and the environment. The genome sequence can contribute to strategies for improving trees more rapidly or for modifying them genetically. Today, trees are the earth's lungs - and, for example, they can ...

Students build submarine to track Octopuses

...between the buoy and the boat." The team also will modify Shadow's buoyancy system. Water flows into a ballast ring that circles the center of the sub. The amount of water that it takes on determines the sub's buoyancy, allowing it to submerge to any depth. Compressed air tanks on the sides of the sub blow ...

22nd amino acid synthesized and added to genetic code of e. coli bacteria

... recent years, researchers learned to artificially modify a set of translator enzymes so that new amino acids can be genetically programmed in cells to produce novel proteins for biotechnology," explained Joe Krzycki, a professor of microbiology. "Now it looks like nature has been doing the same kinds of ex...

Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets

...the best way to respond rapidly is for the cell to modify a particular protein that already exists, rather t...s that make up the workshop that prepares NEDD8 to modify Cul1 are variations of a larger family of similar enzymes, according to the researchers. These other...

Proteins show promise for mosquito control

...oach, she says, researchers are working on ways to modify the malaria mosquito so that it cannot transmit disease, but it can still take a blood meal. The problem with that approach, she says, is that there are many uncertainties about releasing genetically modified organisms into the environment. Lan bel...

Sandia experiments may reduce possibility of future water wars

...d location and time of watering. That will help us modify the design and operation of the greenhouses." The solar way Experiments are also being planned to use the blocked light to create another asset: solar-generated electrical power. (Greenhouse pumps, timers, and se...

For imitative parrots, wagging tongues may be key to vocalization

...unication, researchers have shown that parrots can modify the sound of their vocalizations by articulating their tongue. Tongue placement is known to be a fundamental mechanism in human speech, but evidence that similar mechanisms can shape vocalizations in other species has been difficult to obtain. In hum...

Genetic map of important tree genes outlined

...ould not produce novel characteristics, but simply modify existing genetic characteristics, he said. Just ...Knowing so many genes in a tree, and being able to modify them easily in poplars with asexual biotechnology methods such as gene transfer, provides a tremendo...

Molecular staples shape a cancer killer

... cells to trigger their suicide. "Our goal was to modify the natural peptide sequence only enough to stabilize or reinforce its shape to improve its pharmacological properties," said Walensky. The researchers used the hydrocarbon stapling strategy to brace the peptide from within. "We substituted non-natu...

Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers

...separate, contaminated rivers. Future studies that modify sediment nutrients from contaminated sites with little or no bacterial activity also could reveal ways to coax poor PCB-eaters into developing healthy appetites for these toxins. Ultimately, PCB-digesting microbes will need to be examined in each con...

PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists

...inant life-forms in sediments. Future studies that modify nutrients in sediments from contaminated sites with little or no bacterial activity also could reveal ways to transform sites with poor eaters into areas that grow microbes with healthy appetites for PCBs. Ideally, the investigators could identify a...

The first engineering of cell surfaces in living animals

...cedent for what we were trying to do, which was to modify the cells of a living animal so that they could undergo a chemical reaction without physiological harm," says Bertozzi. "It was a particular challenge because the living animal is such a complex reaction vessel." The researchers report their results ...

Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers

...fects of different genes, and has the potential to modify gene expression in disease, such as knocking out expression of genes required for tumor growth. He cautioned, however, that further studies are needed to prove the general applicability of this concept. An understanding of siRNA begins with a look...

Clusters of alterations on PIK3CA gene found in brain cancers

...y of genes that encode lipid kinases, enzymes that modify fatty molecules and direct cells to grow, change shape and move. Kinases have been the focus of recent drug development strategies, with some tumor-inhibiting compounds such as Gleevec, which is a protein kinase inhibitor already in use clinically to...

New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine

...dentify an alternative cell line or to genetically modify the Vero E6 cell line by altering its glycosylation pathway, thereby producing vaccines with enhanced efficacy without autoimmunogenic activity." Wang and Lu note that the experimental approaches developed in their research are likely applicable for...

New research suggests previously unrecognized mechanism by which blood vessels are patterned

... vessels. This research could lead to new ways to modify the growth of blood vessels because this receptor seems to tell blood vessels in which direction they should grow," says Epstein. With this finding, researchers hope to one day be able to manipulate where blood vessels go, which may lead to the deve...

UNC research accelerates discovery of novel gene function

...ncluding drug design, Kafri added."We could easily modify the library to find peptides or small molecules with potential to act as inhibitors for a particular cellular state or pathway. Doing so would drastically accelerate the process of high-throughput drug design and testing, taking gene candidates from ...

The key to cell motility

...ps to other molecules inside the cells in order to modify their function. Pak attaches its phosphate to two serine residues within the portion of RhoGDI that Rac normally binds to. These bulky and negatively charged phosphates disrupt the normally cozy bond Rac shares with RhoGDI. Freed from the RhoGDI, ...

Herpes tool allows researchers to customize Alzheimer's vaccine

...m to shuffle the immune response, a flexibility to modify the approach to create a vaccine that is safe and efficacious," says Howard Federoff, M.D., Ph.D., professor of neurology and director of the Center for Aging and Developmental Biology. "This points the way toward shaping and modulating the exact imm...

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