Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
... division. "This work provides a molecular picture that basically proves the mechanism [by which the enzyme works]," said Dr. Wang. "This in turn has implications in the design of anticancer drugs." The studies reveal that yeast topoisomerase II is he...New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...ay be triggered in the body -- through damage to a molecular "safety key" that normally holds cell growth in ch... Cortez is a graduate student in the department of molecular cancer biology. The researchers made their discoveries studying an abnormal gene called BCR-ABL, whi...Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...e. Abnormal "triplet repeat" genes constitute the molecular equivalentof stuttering. They repeat the same sequ...d." "This is at least an initial insight into the molecular genesis ofthese diseases," Burke said. "It is a novel interaction that mayexplain the increase in se...Second Breast Cancer Gene Located
...ed," Stratton said."Due to many recent advances in molecular biology, we have managedto shorten the process for BRCA2 to half that time." The researchers do not yet know whether BRCA2 plays a role in the developmentof sporadic, or non-inherited, breast cancers. "Although important in increasi...Transgenic Rice Plants Resist Insects, Drought And Salt Damage
...," said Ray Wu, Cornell professor of biochemistry, molecular and cell biology, and leader of the international ...ents on the transgenic rice technologies. Now that molecular biologists know how to transfer the insect-resistance gene to rice, Wu predicted, it should work aga......ses:cells that wander too far from their source of molecular signals naturallyself-destruct. When the self-destruction mechanism is disrupted, though,cancerous tumors made up of rapidly reproducing cells can result....Florida Researchers Discover Gene For Fatal Childhood Disease
...oteins within cells, said Dr. Stephen Kingsmore, a molecular geneticist atthe Center for Mammalian Genetics at UF's College of Medicine. InChediak-Higashi syndrome, the gene functions abnormally and many proteins failto be delivered to their correct destinations within cells. Scientists also believe th...Genetic Alterations Linked To Cancer In Some Blood Samples
Using a recently developed molecular test, investigators at The Johns Hopkins University School of Medicine have detected genetic mutations specific to cancer in blood samples of six patients with head and neck cancer. Their findings are reported in the September issue of Nature Medici...Low-Protein Diet May Reverse Kidney Disease
...udy's lead author and a professor of pharmacology, molecular sciences and medicine. The study, which was supported in part by the National Institutes of Health, is published in the September issue of the American Journal of Kidney Diseases. "Five patients remain virtually cured, while only one patient's blood-...... researchers say. The technique could be used for molecular investigations about human medical disorders at th...n of a totally unknown molecule. Just knowing the molecular weight at our accuracy level is a big help," said Fred W. McLafferty, Cornell professor emeritus of ...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
... paper's other senior co-author. He isprofessor of molecular and cellular biology at Harvard University. Otherco-authors of the paper are Duke graduate and medical student Timothy Fields,and Harvard graduate student Timothy Hunt. The research was supported bythe American Cancer Society and the National Science...Major Plant Genome Research Project Underway
...established worldwide as the species of choice for molecular genetic studies of plant biology," says Clutter. "Decoding the DNA of this model plant will provide a complete catalog of all the genes involved in the life cycle of the typical plant, from seed to flower and fruit," says Martha Krebs, direct...Discovery Could Help Understand Breast-Cancer Therapies
... researcher BenitaKatzenellenbogen, a professor of molecular and integrative physiology. The research was publ...ational Institutes of Health, was conductedusing a molecular biological technique called alanine-scanning mutagenesis,in which a different form of amino acid is ...Researchers Identify A New Cellular Structure: The "Dumposome"
...olve genetic markers that identify the doomed DNA, molecular scissors to snip it out, and enzymesto degrade it (all of which Allis suspects work in tandem with dumposomes), but they did not anticipate finding aseparate structure devoted to DNA degradation. Dumposomes seem to target heterochromatin, a dist...Green Glow: Not Only For Halloween
...eatures and used to make objects glow green. Now, molecular and cellular biologists have turned this marvel in...amal Shukla, program director in NSF's division of molecular and cellular biosciences, which funded the research. "The green color results from the collapse of ...Cholesterol Anchor Helps Signaling Proteins Direct Development
...ys Philip Beachy, Ph.D., an associate professor of molecular biology and genetics and a Howard Hughes Medical Institute investigator. "I'd be very interested in the effects of cholesterol levels and the presence of substances that affect cholesterol formation." He cautions that many of the patterning events di...Study Examines How Mechanisms Evolve To Regulate Bee Development
...With such simplicity,it may be possible to develop molecular genetic tools for analyzing underlyingbrain mechanisms involved in behavioral changes that could be applied tomore complex genetic systems." For the drones themselves, early maturity brings mixed returns: They canbegin looking for a mate earlier, bu...Cornell Scientists Find Way To Boost Rice Crop Yield -- They'll Walk On The Wild Side
...TL -- that would tend to boost production. Before molecular genetics breeders had no way of finding the genes from the wild species, because there was no way of identifying the functions of the genes in the wild species. Not only is rice being genetically mapped, but other researchers throughout the world ca...Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
...kin cancer. Understanding of these diseases on the molecular levelis minimal. But since the helicase's job is t... that RTP actually interacts with the helicaseon a molecular level. "There's a flexible region on the helicase thatthe RTP seems to interact with," said White. ...