Tag: "mouse" at biology news
Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...l to really prevent the development of cancer in a mouse
model. "However, our data fit in with the general picture that lycopene and vitamin E may have chemopreventative effects on prostate cancer. Therefore we would certainly recommend that all men regularly eat lycopene and vitamin E-rich foods: for exa...
Researchers determine genetic cause of Timothy syndrome
...th muscle and testis. In particular, said Keating, mouse
studies showed the gene to be active in brain regions that were known to show abnormalities in autism. Cell culture studies of the mutated version of the channel revealed that it did not react properly to block calcium flow at the appropria...
EMBO Gold Medal 2004 goes to Spanish scientist
...ently Blasco knocked out the telomerase RNA in the mouse
producing a powerful tool to understand the role of telomerase on cancer and aging. In 1997, Blasco started her own research group in mammalian telomeres and telomerase at the National Centre of Biotechnology in Madrid. Most recently, the scientist m...
Half-million dollar landmark achieved for the Methuselah Mouse Prize
...elop the longest living Mus musculus, the breed of mouse
most commonly used in scientific research. This is a critical precursor to the development of human anti-aging techniques. Currently, six teams around the world are vying for the prize, and this new contribution is expected to swell that number. "By ...
Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...ncers that have spread into the lungs of mice. The mouse
study, reported in the Sept. 21 issue of the journal Proceedings of the National Academy of Sciences by scientists at Cerus Corp. in Concord, Calif., employs a genetically engineered listeria bacteria based on a strain created by coauthor and Unive...
Cardiac arrest may hinder ability to learn certain tasks
...for eight days to acclimate them to the maze. Each mouse
had 60 seconds to swim around the circular, two-me...orm. The researchers tracked how long it took each mouse
to reach the platform, as well as how fast and how many meters the animal swam during its search. ...
Gene clusters predict atherosclerosis severity, susceptibility
... The research team plans further studies in animal mouse
models of atherosclerosis to further refine their techniques. Since it is not practical to test samples of aortas in living patients, the also researchers hope to develop a way to correlate their findings in the aorta with possible markers in circula...
Evidence builds for potential new cancer drug target
...s was accomplished by deleting the c-myb gene in a mouse
model. New technology allowed the scientists to delete c-myb from one specific type of tissue in the model rather than from the entire organism. "We removed the c-myb gene from T cells and in the process discovered that c-myb is required for white b...
Marijuana use could cause tubal pregnancies
...bes for the first time how the CB1 receptor in the mouse
regulates muscle contraction to move the embryo do...Kansas City, Dey and his colleagues found that the mouse
pre-implantation embryo, or blastocyst, had much higher levels of the CB1 receptor than did the brai...
Cannabis may help combat cancer-causing herpes viruses
...n the presence of THC. While cells infected with a mouse
gamma herpes virus normally died when the virus was reactivated, these same cells survived when cultured in the laboratory along with the cannabinoid compound further evidence that THC prevents viral reactivation. Furthermore, the researchers showe...
16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'
...py instead of (or before) killing them. Successful mouse
study leads to patient trial. * Professor Eric Van Cutsem: International trial results shows way to measure success of centuximab (Erbitux). Randomised study now under way Chairman: Professor Jaap Verweij (EORTC chairman of conference scientific comm...
Key stimulator of colorectal cancer identified
...hat are believed to be an early stage of CRC. In a mouse
model system for studying polyp formation, PGE2 treatment induced an increase in the number and size of intestinal polyps. Importantly, this effect of PGE2 was not observed in these mice when they lack PPARd. "Our results identify PPARd as a criti...
Research suggests new avenue for stopping, preventing colon cancer
...derbilt, with maintaining the PPARdelta "knockout" mouse
colony that made the study possible. Dey, DuBois and their colleagues previously have demonstrated the importance of PPARdelta in implantation of the embryo during development. The study's lead author was Dingzhi Wang, Ph.D., research associate profe...
Targeted therapy knocks out pediatric brain cancer in mice
...novel therapies." Dr. Curran and colleagues used a mouse
model of medulloblastoma that they had developed t...inct pathways important for tumor cell growth. Our mouse
studies with HhAntag offer the hope that such precise, targeted molecular interventions could spare ...
New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...nflammation-induced tumor growth, the team studied mouse
lung tissue as well as tumor nodules for expression of specific proteins known to modulate the body's normal cell-killing process. Death-inhibiting proteins were abundant in tumors formed by cancer cells with normal NF-kB, but were absent in the tum...
Popular Science announces Third Annual 'Brilliant 10'
...illionth the size of a grain of rice--he witnessed mouse
neurons sprouting new branches in response to unfamiliar tasks, and saw new synapses appear. Svoboda's work contradicted the mainstream view that neural circuitry is fixed after childhood and may lead to methods of repairing the memory-formation syst...
New way to protect brain from stroke damage
..., acidic and ischemic conditions activate ASICs in mouse
brain neurons, leading to an influx of calcium, they showed. Two agents known to block ASICs--the drug amiloride and the tarantula venom called PcTX--protected the nerve cells against acid-induced injury. Cells lacking ASIC1a, the calcium-permeable t...
JCI table of contents September 15, 2004
...Faculty of Medicine, have bred an ath-erosclerotic mouse
model (apoE/) with mice that were deficient in eit... from the Scripps Research Institute, transplanted mouse
or human adult bone-marrowderived stem cells in the retinal nuclear layers of two different mouse
Picking prostanoids to provide protection
...Faculty of Medicine, have bred an ath-erosclerotic mouse
model (apoE/) with mice that were deficient in either the PGI receptor (IP) or the TXA receptor (TP). These mice allowed the authors to examine the effect of loss of PGI or TXA action on atherosclerosis development. Relative to apoE/ mice, the apoE...
Peering inside the body, with a new spinliterally
...spin. What's the angle? Why, magic. Its subject--a mouse
in a form-fitted Plexiglas tube--performs the hono... dead) rabbit flesh. He also has taken disembodied mouse
livers and brains for slow spins around the magnet, revealing chemical spectra in tissue up to 10 ti...
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