Tag: "mutations" at biology news
Tumor Suppressor Gene Located In Liver Cancer Cells
...rocess of screening the large gene for one or more mutations
that might disable it. Using a method to detect m...ells and surrounding normal tissue, and discovered mutations
in the tumor samples. The discovery of identical mutations
in more than one tumor indicated potenti...
Second Breast Cancer Gene Located
...ases of early-onsetbreast cancer that did not have mutations
in BRCA1. Using DNA from these families, ...gene resides, Futreal said. The inherited mutations
appear to damage the cell's ability to avoid theabnormal growth that characterizes cancer, Futreal s...
Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...lackshear'sgroup will soon begin a study to see if mutations
in the gene correlatewith autoimmune disease in people. "The TTP-deficient mouse is an exciting new model of arthritis,"said Haynes, chairman of medicine at Duke and director of the Duke UniversityArthritis Center. "It also provides important new ...
Mutate Or Die: New Polymerase Gives Desperate Yeast An Option
...but it does so bydramatically boosting the type of mutations
that, in humans and other animals, sometimes becom...e for the enzyme have only about 5 percent as many mutations
as "normal"yeast. Mutations are a risk wherever there is damaged DNA -- and damaged DNA is an ...
Salvage Gene Is At The Root Of Many Mutations
... researchers has unexpectedly discovered that most mutations
in yeast are causedby the activity of an enzyme th...nisms, they made a startling discovery: Almost all mutations
inDNA, ironically, result from the activity of one of the DNA repair enzymes, REV1. "We really ...
Genetic Alterations Linked To Cancer In Some Blood Samples
...niversity School of Medicine have detected genetic mutations
specific to cancer in blood samples of six patients with head and neck cancer. Their findings are reported in the September issue of Nature Medicine. "Although quite preliminary, these findings are interesting, because the presence of DNA alteration...
Green Glow: Not Only For Halloween
...rs, including orange and red, by introducing other mutations
into the protein. The uses for GFP are almost unlimited, they say. In gene therapy, doctors could inject GFP along with the therapy substance, and by checking for fluorescence, determine whether the therapy had been properly delivered. By "...
Researchers Find Genetic Clues To Intestinal Disease
...ated that the disease, which is probably caused by mutations
in several yet unidentified genes, may be made worse when there are numerous copies of these mutations, called a triplet repeat. "Our finding of genetic anticipation in Crohn's disease will help researchers look for the genes responsible for the dise...
Scientists Identify Retrovirus-Like Components In Corn Genome
...mutations, you could wind up with more than 30,000 mutations
per individual plant, and a dead host." Instead, the retrotransposons insert themselves in positions where they tend to be inactive, allowing them to sit quietly and not drain energy from the host, he says. The result is that the mobile DNAs "hide" w...
Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
... years ago using X-ray crystallography.Engineering mutations
at the molecular level, the scientists changed oneamino acid in RTP to test their hypothesis that it interacts with a specificregion on the helicase. "Identifying the corresponding proteins from a human system andthen finding a mutant protein w...
Two Long-sought Diabetes Gene Found
...d Hughes Medical Institute, traced the disorder to mutations
of two similar genes one on chromosome 12 and one ...s from MODY3 families had one of several different mutations
in the gene for hepatocyte nuclear factor 1 alpha (HNF-1-alpha) but healthy subjects had normal copi...
Scientists Identify Gene For Sexual Behavior In Male Flies
...fly Drosophila melanogaster . Male flies with some mutations
in the fru gene become bisexual -- they cannot tell other males fromfemale flies when courting. With this research, the team of geneticistscloned and isolated the fru gene, and showed that it controlsmuch more than the male's choice of partners. ...
Bigger Biology Tackled Through Keyboards
...ferent scalesand timelines, from the rapid genetic mutations
of certain viruses to thelong-term impact of species extinctions on global ecological processes. Fortunately, a relatively new field of science known as computational biologyis coming of age, according to a review paper in the Jan. 17 issue of thewe...
Ten Years of Progress For Superfund Basic Research Program
...-heterocyclics." Many compounds in thatgroup cause mutations
and can lead to cancer. Brian Kinkle,assistant professor of biological sciences, says Sphingomonasshows great promise for bioremediation work. "It's an interesting genus of bacteria they keep finding inmore and more polluted sites. We find it in grou...
NIH Team Discovers Endocrine Tumor Gene
... The researchers say they wouldn't be surprised if mutations
of MEN1 also contribute to the growth of other mor...rchers applied a powerful method of searching for mutations
called dideoxy fingerprinting. If no mutations
were found, a candidate gene was excluded. After te...
New Evidence For Corn's Ancestry Could Lead To Insect And Drought Resistant Crops
...intes. Most other experts believe natural genetic mutations
actually causedthe spikes of some wild teosinte plants to directly evolve into the firstprimitive ears of corn, Eubanks said. Under that hypothesis, Native Americansthen improved the first corns through accidental or intentional breedingefforts. But...
Evolutionary Advantage Found For Sex
...ulations are better at removingundesirable genetic mutations
than single-sexed yeast. "Why sex evolved is one of the big unanswered questions of evolutionarybiology," Zeyl says. "This is one of the first examples of finding anevolutionary advantage for sex. "Vertebrates are almost all sexual, a...
Second Look Acquits Gene Of Role In Breast Cancer
...nd in other cells. They found nosign of deletions, mutations
or other damage to TSG101 in any of the cells. The cancer cells introduced mistakes into the gene's protein-buildinginstructions,Feinberg says, but did so after "reading" the gene, which was not mutated. "The cell encodes genetic instructio...
Second Gene Responsible For Tuberous Sclerosis Complex Identified
...y family--regardless of genetic history. Sporadic mutations
arebelieved to occur around the time of fertilizat... and in the UK and the Netherlands. In the study, mutations
in the TSC1 gene were identified in 42 TSC patients orfamilies and in about half the mutation consis...
Evolution Re-Sculpted Animal Limbs By Genetic Switches Once Thought Too Drastic For Survival
...res in every animal studied. Butbecause laboratory mutations
in these genes can cause monstrosities--such as afly with legs where its antennae should be--many scientists doubted that naturalvariation of homeotic genes could underlie the incremental, survivable changesthat accrued over eons as animals gradually...
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