Tag: "nci" at biology news

Marijuana use could cause tubal pregnancies

Marijuana use may increase the risk of ectopic (tubal) pregnancies, researchers at Vanderbilt University Medical Center reported this week. ...The researchers studied CB1, a "cannabinoid" receptor that binds the main active chemical for marijuana, delta-9-tetrahydrocannabinol (THC). ...In pregnant mice that lacked the gene for the receptor, or in which the receptor was blocked, the embry...

16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'

The 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics brings 2,000 international cancer experts together to present new data on leading-edge basic, translational and early clinical research....... ...12.30 hrs CET Thursday 30 September... ...Speakers and topics: ... * Dr. Jacqueline Limpens: Study shows lycopene and vitamin E inhibits growth of prostate tumours in mice, u...

16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics

The 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics brings 2,000 international cancer experts together to present new data on leading-edge basic, translational and early clinical research....... News briefing:...... 12.30 hrs CET Wednesday 29 September: ...... Speakers and topics ... ... * Dr Monika Hegi: Trial identifies which brain cancer patients benefit from temozol...

AACR applauds NCI initiative on nanotechnology

To better understand the molecular steps that result in cancer and its spread, scientists and clinicians increasingly are turning to smaller and smaller probes that not only act as microscopic sentinels, but also as tools capable of interfering with these processes.... ...For this reason, the American Association for Cancer Research applauds the new initiative announced today by the National Canc...

Final Alert: 16th EORTC NCI AACR Symposium

There are now only three weeks to go to this joint European Organisation for Research and Treatment of Cancer, US National Cancer Institute and American Association for Cancer Research conference....... ... First-time public presentations on new cancer drug research and development from experts in Europe, North America, Asia and Australia.... Free registration to bona fide media with official p...

Rising childhood leukaemia incidence prompts conference

London, UK: The advances in treating childhood leukaemia over the last forty years have been one of cancer's outstanding success stories but the fall in mortality has diverted attention from a rise in incidence, a London conference will hear (Monday 6 September). ......"The marked disparity between incidence and mortality trends crystallises the problem posed by childhood leukaemia from a public...

Other highlights in the September 1 JNCI

... ...Retinoic acid therapy has been used as a treatment for neuroblastoma, but the drug can also make some neuroblastoma cells resistant to chemotherapy. Because fenretinide, a derivative of retinoic acid, targets a different molecular pathway--one that induces apoptosis, or programmed cell death--in neuroblastoma cells and is well tolerated, there has been interest in using fenret...

Washington University in St. Louis plays key role in sequencing moss genome

Washington University in St. Louis will be involved directly with sequencing the entire genome of the moss, Physcomitrella patens, at the Joint Genome Institute (JGI) in Walnut Creek, Calif. The Community Sequencing Program at the United States Department of Energy chose a proposal submitted by Ralph S. Quatrano, Ph.D., Spencer T. Olin Professor and Washington University biology department chair...

JGI announces community sequencing program portfolio

WALNUT CREEK, CA--Despite the perception that the genetic diversity among animals--ranging from humans to worms--is enormous, the reality is that it pales in comparison to the diversity between the microbes that make up the bulk of the biomass on the planet. ...... Accordingly, to close conspicuous gaps in our understanding of the tree of life, the U.S. Department of Energy (DOE) Joint Genome Ins...

Other highlights in the August 18 JNCI

...... A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibility genes....... Prostate cancer is the second leading cause of cancer death among men in the United States. Family history is one of the most well-established risk factors for the disease, but no genes that confer prostate cancer susceptibility have been found to date....... In an ana...

Medication reconciliation, pharmacist involvement vital to reducing medication errors, study finds

CHICAGO Obtaining complete and accurate medication histories of patients and instituting a medication reconciliation program are vital to reducing medication errors, a new study conducted at Northwestern Memorial Hospital has shown. The study demonstrated that when hospital pharmacists perform medication reconciliation, taking steps to ensure patients receive the correct medication and accurate...

Common call for action on European Research Council (ERC)

August 6, 2004 'Science magazine' today published a letter co-signed by over 50 European scientific organisations calling for urgent action on the establishment of a European Research Council (ERC) a pan-European funding organisation for basic research at a European level. A mass petition of this kind on science policy is almost unheard of in Europe and indicates the importance these organisati...

Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers

A new gene-silencing technique that takes place in the nucleus of human cells, has been demonstrated by researchers at the University of California, San Diego (UCSD) School of Medicine and the VA San Diego Healthcare System. The technique, called transcriptional gene silencing (TGS), provides a new research tool to study gene function and, if continuing studies prove the concept, it could potent...

NHGRI adds 18 organisms to sequencing pipeline

BETHESDA, Md., Wed., Aug. 4, 2004 As part of its ongoing effort to enhance understanding of the human genome, the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health, announced today that the Large-Scale Sequencing Research Network has received the green light to begin sequencing 18 strategically selected organisms, including the orangutan, African savannah...

Other highlights in the August 4 JNCI

...... Low levels of high-density lipoprotein (HDL) cholesterol--the "good" cholesterol--are associated with an increased risk of postmenopausal breast cancer in overweight and obese women, according to a new study....... Low HDL cholesterol is a component of metabolic syndrome, which is also characterized by obesity, glucose intolerance, and hypertension. Both metabolic syndrome and breast canc...

Ancient life form may help create newest technologies

PORTLAND Diatoms, a single-celled marine life form that has been around at least 100 million years, are being harnessed by researchers at Oregon State University to help make progress in one of the newest and most promising fields of science nanotechnology. ... These ancient, microscopic organisms are found in the fossil record as far back as the time of the dinosaurs and, as a major component...

Ancient brewery discovered on mountaintop in Peru

CHICAGO--Archaeologists working in southern Peru found an ancient brewery more than 1,000 years old. Remains of the brewing facility were uncovered on Cerro Bal, a mountaintop city over 8,000 feet above sea level, which was home to elite members of the Wari Empire from AD 600-1000. ...Predating the Inca Empire by at least four centuries, this Wari brewery was used to make chicha, a fermented b...

Researchers look into components of RNA silencing machinery

COLLEGE STATION, July 27, 2004 - Up to 95 percent of a person's DNA is believed to be junk DNA. In order to prevent these relics of evolution from rearranging chromosomes and causing disease, natural mechanisms exist to silence them, according to contemporary theories of chromosome biology.... ...The RNA silencing machinery silences gene expression, by destroying RNA, a molecule that carries o...

16th EORTC NCI AACR Symposium

The revolution in understanding the molecular basis of cancer has lead to the discovery and development of numerous innovative agents 'designer' diagnostics, new prognostic tests, 'smart' drugs and other entirely novel ways of tackling cancer.... ...To bring these new developments to patients as quickly and efficiently as possible requires international collaboration, early and optimal exchange...

Other highlights in the June 16 JNCI

...... A new study shows that common mutations in genes that regulate estrogen metabolism are not associated with breast cancer risk. ...... Several studies have suggested that circulating levels of sex hormones, particularly estrogen, are associated with breast cancer risk, but it is not clear whether changes in the genes that control these levels are associated with breast cancer risk. .........

Specialized brain helped ancient reptiles fly and hunt

ATHENS, Ohio Pterosaurs, which emerged as the first flying vertebrates during the age of dinosaurs, could grow as large as an airplane but soared through the skies with ease. New research suggests that a specialized brain and inner ear structure helped these ancient reptiles to fly and target their prey, a finding that could give scientists insight into the evolution of the brain and visual syst...

NCI awards $7.6 million to prostate cancer research collaboration

ATLANTA--Teamwork pays. A collaborative group of cancer researchers has won a $7.6 million grant from the National Cancer Institute to study the pathways and mechanism for prostate cancer metastasis to bone. ...... Titled "Prostate Cancer Bone Metastasis: Biology and Targeting," the collaboration consists of three separate but interrelated projects. The overall project will be led by Leland Ch...

Wolves are rebalancing Yellowstone ecosystem

CORVALLIS, Ore. - The reintroduction of wolves into Yellowstone National Park may be the key to maintaining groves of cottonwood trees that were well on their way to localized extinction, and is working to rebalance a stream ecosystem in the park for the first time in seven decades, Oregon State University scientists say in two new studies.... The data show a clear and remarkable linkage between...

War on germs gets cutting-edge weapon from ancient world technique

Alexandria, VA May 9, 2003 Ancient Egyptians used it to keep food supplies safe from fungus and mold. The Phoenicians used it to keep water from being spoiled by germs. Today silver is a key ingredient in new high-tech, powder coated finishes that hospitals and doctors offices are using to protect walls, counters and other germ-gathering surfaces. Tomorrow those finishes may be used in home k...

Experiments reveal ancient blood flow map

Scientists studying how developing blood cells migrate to their proper destinations in fruit flies have discovered the ancestral role of a protein better known for ensuring that tumors have adequate blood supply. The protein, called vascular endothelial growth factor (VEGF), has gained notoriety for guiding the development of new blood vessels that nourish cancerous tumors. When researchers bloc...

Key principles for the foundation of a European Research Council (ERC)

The presidents and chairpersons of Europe's research organisations, known as the European Union Research Organisations Heads Of Research Councils (EUROHORCs), under the leadership of the current president, Professor Ernst-Ludwig Winnacker, President of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), have agreed on the key principles for the foundation of a European Research...

OHSU scientists find gene influencing drug withdrawal

PORTLAND, Ore. -- One of the genes that influences drug physical dependence and associated withdrawal has been identified at Oregon Health & Science University....... The gene, Mpdz, is involved in physical dependence on a class of drugs known as sedative-hypnotics, which are widely used for their euphoric and sedative effects. Drugs in this class include alcohol, inhalants, barbiturates, benzodi...

Other highlights in the July 7 JNCI

... ...One purpose of a phase I clinical trial of a new cytotoxic drug is to determine the side effects associated with increasing drug dose, i.e., determine the dose that produces the maximum effect at which the toxicity can still be tolerated. New targeted, non-cytotoxic anticancer agents, such as small-molecule kinase inhibitors, pose challenges to this paradigm because they can achieve their...

Combination of gene therapy and gene silencing prevents neurodegenerative disease

University of Iowa researchers have shown for the first time that gene therapy delivered to the brains of living mice can prevent the physical symptoms and neurological damage caused by an inherited neurodegenerative disease that is similar to Huntington's disease (HD).... ...If the therapeutic approach can be extended to humans, it may provide a treatment for a group of incurable, progressive ne...

Kangaroo hops in line for genome sequencing

SAN FRANCISCO, Tues., June 8, 2004 The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced a partnership with the Melbourne-based Australian Genome Research Facility Ltd. (AGRF) to sequence the DNA of one of Australia's best-known animals: a member of the kangaroo family known as the tammar wallaby. ......"This scientific collaborat...

VIB presents its annual results at BIO2004 in San Francisco

San Francisco, BIO2004; The North American biotech convention 'BIO' has blossomed into the place to be. Every year, the international biotech community gathers together at this mega-happening, which this year boasts 20,000 participants. VIB (the Flanders Interuniversity Institute for Biotechnology) is coordinating the Belgian delegation to 'BIO 2004' in San Francisco, where it will present its...

Other Highlights in the June 2 JNCI

...A new study shows how testing for an immune response to the prostate cancer biomarker alpha-methylacyl-CoA racemase (AMACR) could be used to help detect prostate cancer in men with intermediate prostate-specific antigen (PSA) levels.... ...Although PSA screening for prostate cancer has become widespread in the United States, the test has a high rate of false positives because benign diseases,...

Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth

NEW ORLEANS May 26, 2004 -- The discovery of millions of micro-microbes surviving in a 120,000-year-old ice sample taken from 3,000 meters below the surface of the Greenland glacier will be announced by Penn State University scientists on 26 May 2004 at the General Meeting of the American Society for Microbiology in New Orleans, Louisiana. The discovery is significant because it may help to def...

Other highlights in the May 19 JNCI

... ...Combinations of docetaxel, cisplatin or carboplatin, and the monoclonal antibody trastuzumab are feasible for the treatment of patients with HER2-positive advanced breast cancer in which tumor response rates are high, according to two new studies.... ...Human epidermal growth factor receptor 2 (HER2) is overexpressed in the tumors of 20-30% of breast cancer patients and is associated with...

Busy sequencing technique saves money and time

A computer scientist at Washington University in St. Louis has developed a novel technique to extract more DNA from a single sequence reaction than is normally possible, reducing both cost and time of the sequencing process. ... Michael R. Brent, Ph.D., associate professor of computer science, has applied software developed in his Washington University laboratory that sorts through the maize of...

Archaeologists announce discoveries at the ancient Maya site of Waka' in northern Guatemala

DALLAS (SMU) -- An international archaeological project, sponsored by Southern Methodist University, headed by Dr. David Freidel of SMU, and Guatemalan archaeologist Hctor Escobedo of Universidad de San Carlos de Guatemala, is attempting to combine scientific research of the ancient Maya past of Guatemala with conservation and development in an effort to save a vital section of tropical rainfores...

Other highlights in the May 5 JNCI

...... Higher plasma selenium levels are associated with a decreased risk of advanced prostate cancer, according to a new study. This may indicate that higher selenium levels could slow prostate cancer tumor progression....... Haojie Li, M.D., Ph.D., of Brigham and Women's Hospital and Harvard Medical School, and colleagues analyzed plasma samples, obtained in 1982, from a subset of healthy men...

Chromatin remodeling may open up DNA to RNA-mediated silencing

In a finding that deepens our understanding of epigenetic regulation, researchers at the Gregor Mendel Institute of Molecular Plant Biology in Vienna have identified a novel protein in Arabidopsis that may help so-called short guide RNAs and silencing effector proteins target specific DNA sequences for modification.... ...The 'nuclear side' of RNA interference (RNAi) is increasingly recognized...

What it Takes: Design principles to broaden participation in SET

(Capitol Hill, Washington, D.C.) Building Engineering and Science Talent (BEST) today announced the results of its final assessment of best practices in pre-kindergarten through grade 12 math and science education to keep women, minorities and persons with disabilities on the educational path to careers in science and engineering.... The report, titled "What it Takes: Pre-K-12 Design Principles...

Ancient Greeks help scientists build environmentally friendly nano devices

A new generation of materials inspired by the ancient Greeks have been developed by scientists for use in miniaturised devices. The materials are robust, flexible films with perforations on the nano scale and have nano coatings. They are environmentally safe and will enable ultra-fast optoelectronic communication. They are produced by the self-assembly of an intricate 3D jigsaw which is then fill...
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