Tag: "neurofibromatosis" at biology news

Team Of Max Planck Scientists Elucidates Structure Of A Protein Segment Involved In 'Von Recklinghausen Neurofibromatosis'

...in the pathogenesis of numerous tumors, linking neurofibromatosis to tumor development. The work, published in th...inghausen neurofibromatosis, also called type 1 neurofibromatosis or simply NF1, is an inherited disease that predisposes the formation of certain types of tumors ...

Older fathers more likely to have children with schizophrenia

...ge include prostate cancer, nervous system cancer, neurofibromatosis (fleshy growths of abnormal nerve tissue), the most common type of dwarfism, Apert syndrome (malformation of the skulls, hands and feet), and Marfan syndrome, which involves defects of the eyes, bones, heart and blood vessels. The schizophrenia stu...

New pathway to understanding circadian rhythms

...1 -- A gene implicated in the human nerve disorder neurofibromatosis type 1 has been shown to play an important role in...rd reports from clinicians that some patients with neurofibromatosis type 1 develop sleep disorders. Nf1 is a tumor suppressor gene, and patients with a non-functioning,...

Gene that prevents tumor growth also carries messages from circadian clock

...ts by physicians that many patients suffering from neurofibromatosis also suffer from sleep disturbances. But this is the first time someone has definitively linked Nf1 to the circadian system, said Julie Williams, PhD, first author of the study by scientists at the University of Pennsylvania School of Medicine. Their...

Tiny molecular change inactivates tumor suppressor gene in neurofibromatosis

... 2002 A tiny change in the cells of patients with neurofibromatosis (NF) seems to contribute to formation of aggressiv...lecular variation in some tumor samples taken from neurofibromatosis patients. Neurofibromatosis is a common, inherited genetic disease that affects about one in 3,500 ...

Researchers identify potential treatment for learning disability in neurofibromatosis

...ers studying learning disabilities associated with neurofibromatosis type 1, or NF1, have traced the problem to excessive activity of a crucial signaling molecule and have successfully reversed the disabilities in mice by giving them an experimental drug. The findings provide hope that these learning problems may one...

Making meningiomas: Scientists pioneer animal model of human meningioma

...an be associated with a hereditary disorder called neurofibromatosis type 2. Neurofibromatosis type 2 (NF2) is caused by mutations in the NF2 gene, a tumor suppressor gene whose disruption facilitates the development of cancer. However, both sporadic and familial cases of meningioma development are often associated wi...

Researchers identify cell, genetic environment behind nerve-tissue tumors that lead to cancer

... todays edition of Science, reveals that tumors in neurofibromatosis 1 (NF-1) patients form out of a particular type of... approach to combating NF-1. Zhu has been studying neurofibromatosis since 1995, when as a graduate student he joined the lab of Dr. Luis Parada, director of the Center ...

Study finds link between common neurological disorder and Alzheimer's disease

...nal of Biological Chemistry. The protein shared by neurofibromatosis and Alzheimer's disease is kinesin-1, known to be ... most aspects of their activity in the body and in neurofibromatosis have remained a mystery. Neurofibromatosis is a common disorder, more prevalent than cystic fibrosis...

Neurofibromin: It's so degrading

...sing therapeutic implications for the treatment of neurofibromatosis type I (NF1), a common hereditary disease that res...sing therapeutic implications for the treatment of neurofibromatosis type I (NF1), a common hereditary disease that results from mutations in the neurofibromin gene, as ...

The magic behind merlin

...is encoded by the NF2 gene. Mutations in NF2 cause neurofibromatosis type 2, a hereditary cancer syndrome characterized by a predisposition to develop tumors of the central nervous system. Although NF2 was cloned a decade ago, this paper by Dr. McClatchey and colleagues provides unprecedented insight into the biologic...

Researchers identify important function of NF2 tumor suppressor

... known to be involved in the rare genetic disorder neurofibromatosis type 2 (NF2). The protein, called merlin, plays a key role in cell-to-cell communication and may be involved in other types of cancer. The discovery also may support the theory that some tumors are destined to spread or metastasize from the outset,...

Ancient DNA analysis unveils mystery of history's most horribly deformed man -- The Elephant Man

... that Merrick may have suffered from either type 1 neurofibromatosis (NF 1) or Proteus Syndrome, the DNA evidence did not conclusively prove that Merrick had either on its own or the two together. Based on published clinical features, cancer geneticists and other clinical geneticists believe that Merrick had at least ...

Brain tumor growth requires abnormal neighbors

... St. Louis. In trying to develop a mouse model of neurofibromatosis 1 (NF1), a genetic disorder that predisposes children to certain types of brain tumors, the team discovered that tumors only developed when all brain cells were genetically abnormal, not just the cell type that becomes cancerous. The study is feature...

RICE gets $1.1m from DOD to study neurofibromatosis

...University. "We've developed a fruit fly model for neurofibromatosis that we're using to identify key proteins that reg...esearch Program to develop the fruit fly model for neurofibromatosis and to test several key proteins it has already identified as playing a key role in NF. For example,...

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