OHSU-VAMC study sheds light on estrogen's benefit for MS
PORTLAND, Ore. For years, doctors have suggested the best treatment for multiple sclerosis is pregnancy. Now, an Oregon study is delivering solid evidence to support the theory.... ...Researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center have uncovered the mechanism by which estrogen, produced in high volumes during pregnancy, boosts the expression an...New OHSU lab will speed drug discovery process
PORTLAND, Ore. Oregon Health & Science University researchers will more quickly move benchtop discoveries toward drug discoveries with the help of a new, service-oriented laboratory focused on bioanalysis and pharmacokinetics.... ...The Bioanalytical Shared Resource, or BSR, located in the Department of Physiology and Pharmacology, OHSU School of Medicine, will analyze drugs, drug metabolite...OHSU researchers discover possible method for early detection, prevention of premature birth
PORTLAND, Ore. — Researchers at Oregon Health & Science University have discovered a method for detecting intra-amniotic infections in pregnant women using state-of-the-art methods. The finding may result in the development of a test for these hard-to-diagnose, but common infections during pregnancy. Early testing followed by treatment could likely prevent numerous pre-term births and the...OHSU researchers discover molecular signaling system controlling aspects of embryonic development
Researchers at Oregon Health & Science University (OHSU) have identified a secreted signaling protein that regulates smooth muscle development in fruit flies. In the absence of a protein called "Jelly Belly (Jeb)," primitive smooth muscle cells fail to migrate or differentiate, according to study results published in the October 2 issue of Nature. ...... "Our research shows that Jelly Belly is re...OHSU scientists find gene influencing drug withdrawal
PORTLAND, Ore. -- One of the genes that influences drug physical dependence and associated withdrawal has been identified at Oregon Health & Science University....... The gene, Mpdz, is involved in physical dependence on a class of drugs known as sedative-hypnotics, which are widely used for their euphoric and sedative effects. Drugs in this class include alcohol, inhalants, barbiturates, benzodi...Ritalin may improve Parkinson's symptoms, OHSU study says
PORTLAND, Ore. A well-known drug used to treat hyperactive children boosts the potency of another drug that reduces Parkinson's disease symptoms, an Oregon Health & Science University study has found.... ...Scientists at the OHSU Parkinson Center of Oregon found that methylphenidate, known commercially as Ritalin, bolsters the effects of levodopa, a drug converted in the brain to dopamine. Methy...New proteomics core at OHSU will speed discovery process
PORTLAND, Ore. Cory Bystrom, Ph.D., remembers not so fondly how it once took him and two laboratory technicians a full day to prepare a total of 60 gel samples.... ...Thanks to the mapping of the human, mouse and other genomes in recent years, the process grew increasingly labor-intensive as demand for faster, more precise protein identification swelled. Technology couldn't keep up with di...OHSU researchers discover possible connection between infant hormone exposure, obesity
PORTLAND, Ore. Scientists at Oregon Health & Science University have discovered a link between exposure to the hormone leptin early in life, and brain formation that likely impacts weight regulation later in life. ......The research was conducted in mice at the OHSU Oregon National Primate Research Center. Results of the study are printed in the April 2 edition of the journal Science. ......"We...Oregon Stem Cell Center result of OHSU research strides
PORTLAND, Ore. -- Oregon Health & Science University's fast-growing stem cell research program, which already has made significant strides in the hunt for human disease therapies, now has a place to call home. ......The multidisciplinary Oregon Stem Cell Center, the first of its kind in the Northwest, is studying cell and gene therapy as an alternative to organ transplantation for pancreatic and...OHSU-led research examines role of copper, iron in diseases
PORTLAND, Ore. For years, scientists have worked to pinpoint what causes the short-circuit of copper metabolism in human cells that leads to two deadly neurodegenerative disorders known as Wilson's disease and Menkes disease.... ...Now, a research team led by scientists at Oregon Health & Science University is working full time at the molecular level of medicine to find out.... ...These "meta...OHSU team discovers compound that lacks estrogen's risks
PORTLAND, Ore. A team of Oregon Health & Science University researchers has discovered a compound that offers the benefits of estrogen but lacks the popular hormone replacement therapy's suspected side effects and risks.... ...Scientists in the OHSU School of Medicine's Department of Physiology and Pharmacology, in collaboration with an organic chemist at the University of California, San Franc...OHSU researchers reveal relationship between weight gain and female hormones
NEW ORLEANS, La. Oregon Health & Science University researcher Judy Cameron, Ph.D., and her colleagues have announced research findings that help explain the relationship between weight gain and menopause. The study helps demonstrate how female hormones appear to play a major role in America's obesity epidemic. The findings may also provide new methods for fighting obesity. Additional data from...OHSU scientists uncover key protein for Fanconi anemia, cancer susceptibility
PORTLAND, Ore. Isolation of a new protein in the Fanconi anemia (FA) pathway is a major step in understanding how proteins associated with the rare, inherited disorder function to ensure normal development and prevent cancer....... The study will appear online during the week of Sept. 14, 2003, and is scheduled for publication in the October 2003 edition of the journal Nature Genetics....... Sci...OHSU researchers publish final results of groundbreaking smallpox vaccination study
PORTLAND, Ore. Final results of a smallpox vaccine study conducted by researchers at Oregon Health & Science University show America's preparedness for a smallpox outbreak may be greater than initially thought. The research shows 90 percent of those vaccinated 25 to 75 years ago maintain a substantial level of immunity. In addition, researchers concluded that in the long term, repeated vaccinatio...OHSU researcher publishes first measurements of 'free-base' nicotine in cigarette smoke
PORTLAND, Ore. -- When it comes to nicotine content, all cigarettes are not created equal, according to a new study by researchers at Oregon Health & Science University. In fact, the study finds that some commercial cigarette brands contain 10 to 20 times higher percentages of nicotine in the so-called "free-base" form -- the form thought to be most addictive -- than believed up to now. The study...OHSU scientists define adult stem cell healing abilities
PORTLAND, Ore. Researchers at Oregon Health & Science University (OHSU) have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells. The study results will be released online March 30 p...OHSU researchers discover brain cell mechanism possibly linked to mental retardation
PORTLAND, Ore. Researchers at Oregon Health & Science University (OHSU) have discovered a key cellular mechanism in the brain possibly involved in mental retardation. The research may be used to develop new drugs or therapies to combat the condition. The research, which was conducted in mice, also may provide scientists with an animal model for mental retardation that will be of use in future st....September 21, 1999, Portland, Ore.-- It's the same story for thousands of overweight Americans.fighting the battle of the bulge. They diet to lose weight, only to regain those.extra pounds once they return to their normal eating habits. Now, thanks in part.to the work of researchers at Oregon Health Sciences University, the actual.neurons involved in coordinating appetite and metabolism control....Scientists at Oregon Health Sciences University have discovered that.mice.lacking a certain brain cell receptor for the chemical messenger dopamine are.supersensitive to alcohol, cocaine and methamphetamine. Their findings appear.in the September 19, 1997, issue of the journal Cell and detail the increased.locomotor activity of mice who lack the D4 receptor. . ."Branching nerve cells communic...