Tag: "phosphorylating" at biology news
Scientists Identify New Gene That Controls Sleep/Wake Cycle
...old down the rateof accumulation of PER protein by phosphorylating
it as soon as it's made," saysYoung. "Phosphorylation is often a mark put on a protein that labels it fordegradation. Because the double-time protein is made constantly, unlike TIM andPER, the only way for PER to survive is for TIM to come in and r...
Move Over, Protein Kinase C, You've Got Company: Munc13-1 Is A Novel Diacylglycerol Target That Modulates Neurotransmitter Release
... C. This kinase enhances transmitter release by phosphorylating
proteins of the release machinery and ion channels in the cell membrane. In addition, protein kinase C is involved in numerous biological processes, including cell division and tumorogenesis. Protein kinase C is activated by a gr...
Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
...ed role of phosphorylation. They did so in part by phosphorylating
twoversions of SF-1 - one mutated to be nonphosphorylatable, one a naturallyoccurring form - and observing the ability of both to activate two SF-1 targetgenes. One gene, MIS, is a growth factor that blocks development of theMullerian duct, which wou...
Breast cancer susceptibility gene
...f cancer. DNA damage repair involves a cascade of phosphorylating
enzymes, or kinases, which regulate the action of specific repair proteins. BRCA1 is believed to be one of these repair proteins. In cells that have lost BRCA1 function, there are increased rates of mutation in response to DNA damage, and therefore ...
Study of primitive life form expected to provide clues to biological processes in higher organisms
...icus, the protein kinases that are responsible for phosphorylating
them, and the protein phosphatases that remove the phosphate groups. Ultimately, he hopes to not only identify all the pieces in the phosphorylation network, but to also dissect the functional relationships between them. The end product will be a mo...