Tag: "preclinical" at biology news
Leader in cancer treatment and prevention research honored
... have advanced cancer prevention from its earliest preclinical
and clinical stages of drug development to definitive, randomized controlled trials. His laboratory and clinical research has emphasized the chemoprevention and treatment of such pervasive and potentially deadly diseases as breast, colon, ovarian, an...
New study shows hope for treating inhalant abuse
... collaborated at Brookhaven Lab on a large body of preclinical
research on GVG as a potential treatment for addic...a.asp , one yet-to-be published]. Results from the preclinical
and early clinical trials show that GVG holds promise as a treatment for addiction to a variety of a...
Chemical derived from vitamin-E shows early promise as cancer drug
...lpha-TEA), to prevent colon and breast cancers in preclinical
animal models. Mice in the study were treated with alpha-TEA for 21 days after an injection of mouse-derived mammary cancer cells that normally would have formed a tumor mass and spread (metastasized) to the animals' lungs. Regardless of whether a...
Safety of isoflavones in dietary supplements targeted by Illinois initiative
...r. "Under the grant, three groups will conduct preclinical
investigations on animal models, looking for a balance of potential effectiveness and safety issues," Helferich said. "We will look at how different doses of isoflavones and the timing of exposure affect breast, brain and adipose tissues (fat). Anot...
Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...isteria to create a vaccine. At the moment, Cerus' preclinical
development programs are focused on two novel cancer antigens, according to a recent company press release. Cerus is collaborating with Johns Hopkins University to develop a listeria-based vaccine targeting pancreatic and ovarian cancers that express...
Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
... following myocardial infarction in a large-animal preclinical
safety study. This study, performed in swine, confirms previous preclinical
work by MacroPore Biosurgery and others suggesting that the Company's proprietary, patented technolo...
Protemix corporation announces discovery of way to repair hearts damaged by diabetes
...oves the excess copper from the body. The study in preclinical
models and in Phase 2 human clinical trials in sub...s. The researchers found reversed heart failure in preclinical
models. They also found that the damaged hearts in the preclinical
models and humans had substantive...
New compound could give some types of cancer the one-two punch
...16, as a model. Although SU-5416 showed promise in preclinical
studies, it did not have the kind of far-reaching effectiveness that researchers had hoped for. -------------------------------------------------------------------------------- "One drug with dual activity means that the body only has to deal with a ...
New designed paclitaxel analog kills more cancer cells than natural product
...eral analogs are in clinical trial, with others in preclinical
development. One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cannot be prepared synthetically in a commercially viable way. "The Holy Grail of paclitaxel research would be to find a c...
Whole body imaging allows better understanding of the immune system
...ny treatment, whether chemotherapy or antibody, in preclinical
and clinical trials." ...
Gene therapy tested to protect bone marrow during chemotherapy
...cells not carrying the gene. Based on those preclinical
animal results, they have begun this clinical trial in patients with advanced cancer. Blood stem cells are collected from patients and exposed to a retrovirus containing the gene, which inserts the gene into the cells. Patients are then infused wit...
Researchers identify two potential protein targets for new drug therapies for pancreatic cancer
...h. Since targeting FAP appears promising in these preclinical
models, we believe our study shows the feasibility of developing such targeted therapy for patients with pancreatic cancer."...
When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
...atory findings hold true in patients. Based on his preclinical
work, a phase I trial of docetaxel followed by erlotinib in patients with non-small cell lung cancer is already under way at UC Davis Cancer Center. Angela Davies, assistant professor of hematology/oncology at UC Davis Cancer Center, is principal inv...
Inhibition of cathepsin proteases inhibits tumor formation in transgenic mice
...traditional) therapies, which could be revealed in preclinical
trials involving this and other mouse models of human cancer."...
A new way to kill cancer: SLU research shows viruses can destroy lung, colon tumors
...esigned to be specific to colon or lung cancer. In preclinical
testing these vectors were highly effective agains...ruses and other related technologies, said: "These preclinical
data are very promising, and support our belief that oncolytic adenoviruses have enormous potential ...
Soy processing influences estrogen-dependent breast cancer growth in mice
... therapies such as tamoxifen. "The results of this preclinical
investigation are especially relevant to postmenopausal women with estrogen-responsive breast cancers who are looking for alternatives to HRT," he said. In the study, mice were fed equal concentrations of the soy isoflavone genistein, allowing Helf...
Dana-Farber launches Center for Applied Cancer Science
...mia, exploiting the predictive value of engineered preclinical
models, and utilizing its vast clinical materials to select the right drugs and patients for specific treatments. The new center's administrative structure will facilitate more effective collaboration with pharmaceutical and biotechnology commercial...
Oregon Stem Cell Center result of OHSU research strides
... involving basic research in stem cell biology and preclinical
trials of therapies in animal models, followed by human trials. "This is something we needed but didn't have," said Grompe, who has long studied gene and cell therapy for metabolic genetic diseases, as well as the molecular genetics of a rare, cancer...
New approach limits damage after heart attack and improves survival, say Scripps Research scientists
...company, TargeGen Inc. in San Diego, is finalizing preclinical
studies to translate these initial research findin...gs into practical human therapies. Using extensive preclinical
models that mirror human heart attacks, TargeGen scientists report that 40 to 60 percent reductions ...
Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
...hrough facilitation of GABA receptor function, and preclinical
studies of alcohol dependence have shown that GABAergic activity decreases during alcohol withdrawal and protracted abstinence--the initial post-acute withdrawal period after the cessation of drinking during which a person is especially vulnerable to...
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