NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
..., the Center will devise computational methods for predicting the behavior of entire biochemical pathways that connect to proteases. Another outcome of research at the Center will be the development of a platform for screening small molecular libraries against all proteases encoded by the genome. Indeed, ear...Trial shows which brain cancer patients benefit from temozolomide
...eva today (Wednesday 29 September) that the key to predicting which patients will gain from temozolomide was a gene called O-6-methylguanine-DNA methyltransferase (MGMT) which is involved in DNA repair and its respective methylation status in the patient's tumour. Methylation is one of the ways that cells con...K-State, other universities to study how climate affects plant evolution
.... The results of the project will be important for predicting how plants will respond to future climate change and will help to inform conservation management and crop improvement strategists, he said. "Being on the forefront of the knowledge that will help feed the world of the future is not only gratifying fo...Lecture on ecology of infectious diseases
...to evaluate the importance of landscape setting in predicting these outbreaks. Plague epidemics in prairie dogs, she found, were related to the surrounding landscape in unexpected ways: prairie dog colonies in urban settings were no more or less likely to experience a plague outbreak than such colonies in more...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...nimals. The new findings one day may be useful for predicting whether and when diabetes will develop in humans. Type 1 diabetes is an autoimmune disease in which the body's immune system mistakenly launches an attack on the insulin-producing beta cells of the pancreatic islets. This process may eventually ...Modest climate change could lead to substantially more and larger fires
...co. Montana is the most sensitive, with the models predicting a 5-fold increase in mean area burned over the observed range in climate, the authors write. In Washington and Oregon, the effects will be intermediate because precipitation and temperature are both associated with fire extent in these states, rathe...NASA satellites detect 'glow' of plankton in black waters
...llites provides effective means for monitoring and predicting such events. The link between coastal runoff and black water events is an example of how land and ocean ecosystems are linked together. "Coastal and land managers over large areas need to work together, to alleviate more black water events from taki...What actually influences air pollution over the Indian Ocean?
...hnique of "chemical weather forecasting", that is, predicting the day-to-day changes in the concentrations of gases like ozone and carbon monoxide. These forecasts indicated on which days the "plume" of pollution would be within reach of a research aircraft stationed on Crete. On three occasions, these forecast...Story tips from the Department of Energy's Oak Ridge National Laboratory, August 2004
...to self-organizing systems has also lent itself to predicting the reaction of electric power grids to increasing power demand or system anomalies. One year after the northeastern blackout drew attention to their work, Oak Ridge National Laboratory fusion researcher Ben Carreras, David Newman of the University o...Climate change could doom Alaska's tundra
...ic Global Vegetation Model MC1, an improved way of predicting what certain climate scenarios will mean in terms in of vegetation growth, plant and soil processes, carbon storage or emissions, forest fire, and other important ecological effects. The latest simulations with this model were done with Alask...Activated signaling pathway may predict lung cancer patients' response to gefitinib
... and also whether phosphorylated Akt has a role in predicting gefitinib sensitivity. Although this new report is interesting, they write, "the findings do not supercede better predictors of response to gefitinib. When patients with NSCLC enter the clinic today, treatment decisions must be guided by both clinica...New framework for biodiversity conservation
...m. "Developers and industry do a far better job of predicting land availability and creating investment opportunities than do conservationists," says Andelman. "It goes beyond conservation science to human psychology figuring out how we can get the pieces of land with the biggest conservation impact. It requir...Mapping the evolution of a virus
... vaccination. The approach also offers a route for predicting the relative infection success of emerging virus strains. According to Los Alamos computational biologist Alan Lapedes, "This collaboration was particularly exciting because it involved close interaction between experts in computation and virology an...Gene expression patterns may help predict risk and progression of prostate cancer
...profile model was more than 80 percent accurate in predicting the aggressiveness of the disease. "Since only a fraction of prostate cancers are metastatic, identifying variables that predict the behavior of a prostate cancer tumor based on gene expression patterns should prove important in clinical man...Leading scientists design new framework for biodiversity conservation
...m. "Developers and industry do a far better job of predicting land availability and creating investment opportunities than do conservationists," says Andelman. "Right now conservation planners aren't even using realistic data for the cost of land." Andelmen and Possingham are now leading the charge to revamp th...Carnivore species are predicted to be at increased extinction risk from human population growth
... Biology, could help focus conservation efforts by predicting which species face greatest risk. The model predicts risk based on the density of local human populations combined with various traits of different species of carnivores, such as their population density, gestation length, and habitat range. The rese...Genetic mutation found that is major contributor to type 1 diabetes
... needle in a haystack which narrows the search by predicting which of some 40,000 genes might be involved in a disease based on what scientists already know about the disease and the genes. "You guess the function, you guess the disease possibilities, then you guess which genes might be involved in the pathoge...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...signs of the disease are present, with the goal of predicting the development of kidney disease in lupus patients. David S. Pisetsky, MD, PhD, Duke University Medical Center, Durham ROLE O HMGB1 (HIGH MOBILITY GROUP PROTEIN) IN THE PATHOGENESIS OF SLE. Dr. Pisetsky's research will focus on a protein calle...... change. "But in the short term, we have a problem predicting what aerosols do to the climate. The best current aerosol models give a cooling force, which is larger than we can explain. This must be balanced by other effects that are not properly accounted for in climate models. But eventually, warming caused b......ogens. The finding has important implications for predicting and managing future infectious disease outbreaks. These results counter the conventional assumption that socioeconomic conditions are the most important factor in controlling disease, indicating that global climate change could have far more signific...