16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...edical Center, Washington, D.C.) Using genomic and proteomic techniques to investigate exercise adaptation in u...and overweight men and women. Comparative mRNA and proteomic profiling provides unique insight into underlying metabolic crisis in chronically untrained muscle a...Joslin President awarded medal from international diabetes organization
... institutions involved in the use of DNA chips and proteomic techniques to study diabetes. A native of Louisville, Kentucky, Dr. Kahn received his undergraduate and medical degrees from the University of Louisville. After training in internal medicine at Washington University, he worked at the National Instit...OHSU researchers discover possible method for early detection, prevention of premature birth
...d other collaborators in 2002. The company employs proteomic and functional genomics technology to discover, develop, manufacture, and commercialize biomarkers for fetal, maternal, pediatric and adult applications. ...Tufts researchers identify a novel target for cancer therapy
.... "These results indicate a role for a functional proteomic approach in addition to genetic screens and suggest anti-hsp90 antibodies may be potential options for cancer treatment." Jay and colleagues collaborated with scientists at the National Cancer Institute and Xerion-Pharmaceuticals AG of Germany on thi...New papillomavirus target could lead to specific antiviral drugs for precancerous cervical lesions
...the entire package in vivo. Using a relatively new proteomic approach developed by Yoshihiro Nakatani, HMS professor of biological chemistry and molecular pharmacology at Dana-Farber Cancer Institute--she extracted E2 plus its many interacting partners and then set out to identify each member in the complex. I...Researchers identify unifying code among diverse classes of natural antibiotics
...nt, PhD, and Michael Yeaman, PhD, integrated novel proteomic methods with established microbiologic techniques ...ise remain unknown. Using a unique combination of proteomic methods, Yount and Yeaman discovered the antimicrobial peptide signature, which integrates inverse a...Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal
...es them to the interior or the embryo. In their proteomic analysis, the Carnegie Mellon scientists found changes in the abundance of many types of proteins well before gastrulation. These included proteins that control metabolism, protein breakdown, protein production and the formation of the cell's interio...New, comprehensive tumor classification combines molecular biology and classic pathology
.... Patterns identified from the gene expression and proteomic data from tumor samples can then be integrated as new groups within this classification. Berman writes: "Some of these groupings will prove to have a specific biologic feature, for example an increased tendency to metastasize, a higher response to a...Children's Memorial, TGen announce partnership
...earchers access to a range of genomic, genetic and proteomic technologies, bioinformatics, high-throughput sequencing, and gene expression profiling capabilities. "Our partnership with TGen recognizes the critical role that science and technology play in unraveling the genetic components of common and complex ...Other highlights in the March 3 issue of JNCI
...hortcomings of one technique used to analyze serum proteomic patterns, surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry. He explains why he thinks it is unlikely that SELDI-TOF will be a useful approach for the diagnosis of cancer. He identifies artifacts that could bia...Proteomics and alcoholism research
... involved in neurochemical pathways. An alternate proteomic approach is to study as many proteins as can be se...of two important species, points to the promise of proteomic screening as a tool to better understand the pathophysiological characterization of alcohol abuse an...Pacific Northwest National Lab unveils most complete human blood-plasma proteome map to date
...e change from normal levels." A fast and sensitive proteomic analysis is necessary for such massive screenings of bodily fluids as needed to confidently identify biomarkers and to bring into sharp focus proteins that are signs of trouble to come. Proteomics is akin to reading the proteins like tea leaves, minu...Proteins may help identify patients who will respond better to treatments in certain cancers
Scientists today presented studies of proteomic and genomic markers that could help oncologists devise better treatment approaches for specific patients, and may improve clinical outcomes. The studies were presented here today at the International Conference on Molecular Targets and Cancer Therape...Cyclacel's biomarker technology shows that CYC202 induces cancer cells to commit suicide
...y Cyclacel's Biomarker Team is the study of plasma proteomic profiles allowing the precise comparison of the proteins present in a patient's plasma before and after treatment with CYC202. Using this approach markers were detected that are only present in plasma following CYC202 treatment. Phase I trials are n...Q Fever microbe's genome is deciphered
...er vaccines and diagnostic tests using genomic and proteomic approaches. The CDCs Thompson, co-editor of the book Q Fever: The Biology of Coxiella burnetii, says, Q Fever research on all fronts will benefit from this new knowledge. Over the last several years, he says, consideration for both the organism Coxi...Proteomics drives new generation of medical treatment
... Cancer Detection The infant process of serum proteomic pattern diagnostics has generally relied on low-re...ercent accurate. Researchers report that multiple proteomic patterns do exist within human sera mass spectra, and that finding multiple patterns provides an ext...New proteomic techniques reveal workings of bacteria linked to cystic fibrosis
...is signaling system by the use of new quantitative proteomic technology that analyzed Pseudomonas samples from ...brosis patients. The highly sensitive quantitative proteomic analysis of a whole bacteria performed in this study implicates a cell signaling system, Pseudomonas...Toxicogenomics provides insight on assigning breast cancer drugs
...ssigning them with a computer-system tool to their proteomic mass spectroscopy, to generate a complex protein "barcode" serum, the computer can datamine between different known toxicities for patients, and have a better basis upon which to assign a drug treatment. Work by Richard Paules at the National Institu...UC Riverside receives $1.25 million from W. M. Keck Foundation
... at the Genomics Institute use the latest genomic, proteomic and bioinformatic techniques to also address questions in mammalian molecular cell biology and human health. The Center for Plant Cell Biology, or CEPCEB, was established in early 2002 and attempts to answer significant outstanding questions in plant...... launched a major initiative to develop innovative proteomic technologies by creating 10 special centers of res...centers' activities. "NHLBI also plans to promote proteomic research by making products gained at the centers readily available to other scientists. These prod...