Tag: "punch" at biology news

Bacterial Toxin Surprises Scientists

... anemone toxins share the same strategy--they punch huge holes in the cell membranes of their victims. Pharmaceutical companies harness this strategy in the potent antifungal medications amphotericin and nystatin. Yet until recently, researchers have known little about ...

Emory Researchers Advance Gene Therapy Studies For Metastatic Melanoma Treatment

...ifference," adds Ansel. "It may pack a much bigger punch than when it is coursing through the circulatory system." Most clinical gene therapy for melanoma now being conducted around the country treats patients systemically, and results have not been particularly promising. "We are experimenting not on...

Researchers Take Major Step Toward Cracking Ebola Code

...plicating. The second part of the glycoprotein 1-2 punch comes from the transmembraneversion of GP. This version attaches to endothelial cells, possibly clearingthe way for the Ebola virus to enter into the cell where it begins itsdestructive process. "These study results provide insight into the strategi...

Dark Honey Has More Illness-Fighting Agents Than Light Honey

...s buckwheat flowers packs 20 times the antioxidant punch as that produced by bees that lap up California sage. Clover, perhaps the most common plant source tapped by honey bees, scored in the middle of the rankings. Antioxidants -- substances that slow the oxidation of other substances -- counter the tox...

Security Code Helps Immune Cells Attack Foe And Spare Self

... of the cell that detects harmful organisms has to punch in acode before the cell will go on the offensive, the researchers have found.Punching in just part of the code is as useless as entering the wrong securitycode into a lock. "People have been trying to identify the steps that occur in the res...

Study Suggests Weekly Hurricane And Rainfall Patterns Are Linked To East Coast Pollution

... that even mighty Atlantic hurricanes may feel the punch of theworkweek, according to a study by two Arizona State University researchersappearing in the journal Nature. Examining some basic data sets in a way that has never been triedbefore, ASU climatologists Randall Cerveny and Robert Balling, J...

Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery

...rly always fatal. In a biochemical one-two punch to brain cancer cells, O'Rourke andcolleagues inactivated a common cell-surface receptor called the EpidermalGrowth Factor Receptor (or erbB for short) to arrest cell growth in humancell lines, which further sensitized the cells to radiation. This ap...

Brookhaven, Carnegie Scientists Report First 'Morphing' Of Plant Enzyme Function

...mical changes. "Picture an enzyme as anindustrial punch press and its active site as the die," said Shankl... done is learned how to change the die to make the punch pressproduce a different product." This achievement, Shanklin continued, means that enzymes...

Head trauma damages DNA repair mechanism

...lt, harsh biochemicals called oxygen free radicals punch holesin the cell membrane, and intracellular proteases called calpains attack thecell's internal skeleton, both of which cause the cell to collapse. Immediatelyafter trauma, various drugs are given to stop calcium entry. But, this cascade of event...

Sports massage of little physical benefit

...d massagewas also unable to prevent a reduction in punch power during the secondperformance. The authors suggest that either blood flow was not affected bymassage, or that it was not sufficiently increased. None of the other bodyindicators differed between the two groups. But the boxers who had been given...

Vaccine controls AIDS in monkeys, researchers report in Science

...d with an extra immune protein, delivers a one-two punch that appears to control a highly pathogenic AIDS virus and prevent the development of the disease in monkeys, a team of researchers reports in the 20 October issue of the international journal, Science . This "vaccine-plus" did not keep these monkey...

Secret to Listeria's virulence provides clues to workings of other deadly intracellular pathogens, UC Berkeley scientists report

...'s normal toxin, the altered bacteria were able to punch their way out of a vacuole, but then they killed the host cell. This made Listeria totally avirulent, Portnoy said, because the immune system efficiently mopped up the exposed bacteria. Portnoy and Decatur compared the genetic sequences of the two to...

Nanopore detector shows discriminating taste in DNA molecules

...on channel, produced by Staphylococcus bacteria to punch holes in cell membranes. Because of the toxin's role in staph infections, it has been studied extensively and its structure is known in great detail. "We know the environment of the ion channel very well, which helps us to understand how DNA molecul...

Bacteria's natural foe fights drug-resistant infections

...ing their next host. Special phage enzymes, which punch holes in the bacterial cell wall, ensure the phage a rapid exit; without this outer layer of protection the bacteria essentially cannot hold themselves together, and, they explode. Fischetti discovered that the phage enzymes also work when applied t...

UT Southwestern researchers link human lymphomas to polio vaccine tainted with monkey virus

... carefully done studies present a powerful one-two punch against skeptics....

Honey the darker the better Has potential as dietary antioxidant

...ey, especially buckwheat, provided more protective punch than lighter-colored honeys. It still is too early to say definitively, but honey seems to have the potential to serve as a dietary antioxidant, said principal researcher Nicki Engeseth, a professor of food chemistry in the UI College of Agricultura...

Promising new therapies for deadly form of leukemia

...ow in clinical trials -- will pack the same potent punch that has made Gleevec (STI571) so effective against chronic myelogenous leukemia. The scientists reported on studies of the new drugs, called PKC412 and CT53518, in two articles that will be published in the June 18, 2002, issue of the journal Cance...

Frozen 'lake' beneath Antarctica ideal to test sterile drilling techniques

...ing techniques needed before scientists attempt to punch through the ice into pristine liquid lakes elsewhere in Antarctica in search of exotic microbes. Techniques that avoid contaminating a drill site with microbes also would prove useful for future drilling into Mars' polar caps in search of life. "This...

Making the most of lymphopenia

... they could be inhibited from growth by the onetwo punch of tumor and T cell injections following lymphopenia. The article "T cell homeostatic proliferation elicits effective antitumor autoimmunity" is authored by Wolfgang Dummer, Andreas G. Niethammer, Roberto Baccala, Brian R. Lawson, Ralph A Reisfeld, a...

The frontier of microelectronics: Building nano-machines, part by part

...Once we decide on the right fit, I'd be pleased as punch if we have one next year that would scuttle across the table and avoid objects." Ellenbogen will also discuss ongoing developments of nanocomputers. "We overestimate what we can achieve in a year and underestimate what we can do in ten years. Nowher...

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