Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...ieve the effect also works for at leastthree other rare neurological disorders -- Kennedy's syndrome, Machado-Josephdisease, and Spinocerebellar atrophy I -- that have the same expanded CAGrepeat. "Traditional dogma is that mutant genes produce proteins that eitherdon't work at all or don't work well," s...Tumor Suppressor Gene Located In Liver Cancer Cells
...es of almost every gene, one from each parent. In rare cases, a gene is imprinted, meaning that only one of the parental copies is active. The M6P/IGF2r is especially unusual, because it is imprinted in mice but not in humans. Lacking the back-up that humans have in case one copy malfunctions, mice are...Duke Researchers Find Second Gene Linked To Blood Vessel Disorder
...l Center researchers have linked asecond gene to a rare bleeding disorder -- a discovery that offers insig...es or aneurysms. "By studying these genes for rare disorders, we are hoping to opena window into how the body's vascular system operates," Marchuk, ass...International Research Team Clones New Skin Cancer Gene
....2 The search for the gene began with studies of a rare hereditary disorder, nevoid basal cell carcinoma syndrome (NBCCS). People with this syndrome often develop thousands of skin cancers and may also have birth defects and childhood brain tumors. In 1992, Bale mapped the NBCCS gene to human chromoso...Nutrition Study Reshapes Strategies For Athletes
...to dehydration during theJune trials in Atlanta, a rare error in athletes at that level. The other key, Houtkooper says, is eating enough of the right kinds of foodsand eating them on a schedule coordinated with their competitions. Lighteris not necessarily better, which flies in the face of some training...Salvage Gene Is At The Root Of Many Mutations
...ual mutations are seldom serious, "if you get that rare mutation that causes cancer, you're introuble," Nelson says. "There's every reason to believe that mutagenesis in humans will prove to be very similar to that in yeast," saysLawrence, noting that Rochester scientists have already identified simi...'Juliet' Evades Primate Center Expedition
...rimatologists were unable to capture amate for the rare lemur called Romeo, in an October 2-16 expedition ... his colleagues said Monday they sighted groups of rare diademed sifakaslike Romeo, but were unable to come close enough for a capture. The diademed sifaka...NCAR Scientists Trek To Africa For Biosphere-Atmosphere Chemistry Study
...l African Republic (CAR), and the Congo complete a rare study of the African atmosphere. Ground-based and tower-mounted instruments and a research aircraft will support studies of biomass burning, rainforest-savanna boundaries, and the influence of tropical vegetation on global air chemistry. This fall's ...Scientists Trek to Africa for Biosphere-Atmosphere Chemistry Study
...e Foundation (NSF)-supported scientists complete a rare study of the African atmosphere. Ground-based and tower-mounted instruments and a research aircraft will support studies of biomass burning, rainforest-savanna boundaries and the influence of tropical vegetation on global air chemistry. This...Blood Test Can Identify Some Children With Strep-Related Behavioral Disorders
...gical disorders. "In psychiatry,this offers a very rare opportunity to catch a disorder early and to treat itaggressively," she said. Swedo urges doctors who examine children exhibiting anabrupt onset of OCD or tic symptoms to check the young people for strep, and ifstrep is present to treat it with penic...Team Identifies Switch For Tumor Suppressor Gene
...tation occurs in cells destined to form the eye, a rare butdeadly form of childhood eye cancer known as retinoblastomaoccurs. More commonly, the gene is missing or mutated in manytypes of cancer cells such as those found in the lung, breast,and ovary. "In all cancers, you have cells that proliferateu...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
... gene therapy and to target livercancer. It's also rare for a vaccine to completely eliminate theformation of cancerous tumors in animals or humans. Lead author of the report is Yuman Fong, M.D., one of theworld's leading liver cancer surgeons, at Memorial Sloan-Kettering Cancer Center in New York Ci...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...ne therapy and to target liver cancer . It's also rare for a vaccine to completely eliminate the formation of cancerous tumors in animals or humans. Lead author of the report is Yuman Fong, M.D. , one of the world's leading liver cancer surgeons, at Memorial Sloan-Kettering Cancer Center. Other authors ...Scientists Trace Roots Of Protein That Keeps Antarctic Fish From Freezing
...nstrations of this sort at the molecular level are rare andnoteworthy." Evolution of the antifreeze gene in the Antarctic fishes had a greatimpact on the ecology of the thermally isolated Antarctic Ocean that existstoday, DeVries said. "If they hadn't evolved this gene, then the AntarcticOcean may be qui...Duke Study Shows Early Marrow Transplant Key To 'Bubble Boy' Disease Cure
...ogy. Buckley said early diagnosis of SCID is rare because doctors do notroutinely perform a test in newborns to count white blood cells. Such ablood test could pick up children with SCID as well as those with otherserious immune deficiencies that would not be apparent until the childdeveloped an in...Two Parasitic Wasps Show Promise For Controlling Pest Flies
...a month later. Spalangia endius wasps, although rare or absent in similar studiesin Kansas and Nebraska, were common in southern Illinois. Because thesewasps already are reared and sold as a biological control, mostly for usein California and Northeast dairies, they may be worth a closer look asa biol...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...key virus in the development of mesothelioma, a rare connective-tissue cancer commonly associated with asbestos exposure. In research reported in the August 3 issue of Nature Medicine , Dr. Giordano's team found that simian virus 40 (SV40), a DNA tumor virus from monkeys, targets ke...Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
... they are folded in a particularway-luckily a very rare occurrence so far. The disease-inducing prions appear tocontain clumps of several prion protein molecules, which damage the brain ofaffected humans or animals. Where and how the clumping occurs has not thus farbeen clear. Professors Kurt Wuethrich an...Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer
...anism behind the development of mesothelioma, a rare connective-tissue cancer commonly associated with asbestos exposure. The virus rendered key tumor-suppressor genes ineffective. The finding was particularly significant, Giordano said, because of the different mechanism potentially involv......n and chemical makeup. He also discovered that on rare occasions it had been suspected---though not confirmed---as the cause of anaphylactic shock and asthma in workers who processed the extract. Physicians often confirm the results of allergy skin tests through a radioallergosorbent test (RAST), wh...