DNA lends scientists a hand, revealing new chemical reactions
...werful way of mining the chemical universe for new reactions by piggybacking collections of different small org...rcher can evaluate thousands of potential chemical reactions in a two-day experiment. "A conventional approach to reaction discovery, in which different reaction...Martin Saunders to receive the James Flack Norris Award
... main species of reactive intermediates in organic reactions including the formation of many natural substances...d mechanisms and rates of very rapid rearrangement reactions of the cation intermediates. Saunders received his Ph.D. from Harvard University, came to Yale as a...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...al infections. In turn, NF-kB sets off a chain of reactions that lead to cancer. Mice used in the new study were given colon or breast tumor cells which metastasized to the lung. Some of these cancer cells served as "controls," while other cells were given a protein that specifically inhibited activat...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...l1, causing it to set off a cascade of biochemical reactions that eliminates the molecular brake controlling ce...es be brought together in a specific manner so the reactions can take place quickly," Schulman said. "That's where the E2 tail comes into play. The shape and loc...Disruption of protein-folding causes neurodegeneration, mental retardation
... processing factory as the location of biochemical reactions leading to brain cell death in children with this disease. "Our finding is exciting because children with GM1 gangliosidosis are severely affected and their outlooks are dismal," said Alessandra d'Azzo, Ph.D., member of the St. Jude department of Ge...Natural mineral locks up carbon dioxide
... these chemicals providing large surface areas for reactions to occur in solution at room temperature. Carbon dioxide passed through the solution of magnesium sulfate and magnesium hydroxide converts both to magnesium carbonate or magnesite, which becomes a solid and falls to the bottom. This solid can be us...Analysis of biological clock may lead to greater understanding of human disease
...neurons of the brain of the fruit fly, setting off reactions of proteins at a certain rate depending on the amount of light. The reactions set the clock. There are key proteins and two key feedback loops involved, making the system a hiera...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...His work sheds light on the molecules and chemical reactions that may have been responsible for the origin of l...s all the time. Stars are born, gasses collide and reactions are set in motion. Here on Earth, physical chemists are tapping new techniques -- including nano-hel...Scientists reinvent DNA as template to produce organic molecules
...f molecules in laboratory reactors. In nature, the reactions between these highly dilute molecules are directed by enzymes that selectively bring certain biological reactants together. Liu and his colleagues are now using DNA as a similar type of intermediary to bring together synthetic small molecules that ar...Sweet success in targeting sugar molecules to cells in living animals
...ey are also developing new bio-orthogonal ligation reactions with azides that will give them additional sugar-tagging techniques....When is a mouse like a test tube?
...the mouse as a reaction vessel, designing chemical reactions that will teach us about biology and disease witho...ears ago, she conceived of the idea of instigating reactions in the body between unnatural chemicals - ones created by humans and never before seen by living org...The first engineering of cell surfaces in living animals
..., literally "at right angles" to biology: chemical reactions artificially induced on the cell surface must be h... what Bertozzi calls "a future arsenal of chemical reactions used to probe the biology of living animals."...UC Riverside researcher takes snapshots of the movement of molecules in a billionth of a second
... advance in surface science, the study of chemical reactions taking place on the surface of solids. The results are reported in the current issue of the Journal Science and were also reported in the June 24 issue of Science Express ... the online prerelease of the most important articles in Science . The a...Plant respiration not just an evolutionary leftover, study shows
...e enzyme that initiates both the light-independent reactions of photosynthesis and photorespiration would favor photosynthesis to a greater extent and minimize photorespiration. The result, they have thought, would be more productive crop plants that make more efficient use of available resources. But the new...Anxiety during pregnancy affects child behavior
...as treatments to reduce anxiety and neuroendocrine reactions to stress throughout the pregnancy, or even before conception. They may benefit not only the mother but also the developing child....UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins
...and KGB1, controlled two "pathways" of biochemical reactions that are essential in allowing roundworms to survive a 30 minute exposure to a high dose of Cry5B toxin. Roundworms missing either of the two genes were hypersensitive to Cry5B and quickly died after such an exposure to a high dose of toxin or to a l...Gene therapy alternative to calcium channel blockers
...ction, is directly involved in the electrochemical reactions that allow muscle cells to contract as part of a regular heartbeat. In the researchers' experiments, standard adenoviral transfer of the Gem gene was made to the AV node of heart muscle, which is where the heartbeat originates. Calcium is vital to m...Researchers discover how worms' noses sense oxygen
...uanylate cyclase, triggering a cascade of chemical reactions that make the muscle relax, opening up the vessel ...or 4 thousandths of an inch) thick - to study worm reactions to oxygen levels. Built at UC Berkeley by UCSF postdoctoral fellow Hang Lu, it has speeded behaviora...Plant pathologists look to forensics to aid in biosecurity
...edge on the genetics, evolution, biology, and host reactions of key microbes. "Guidelines for sample collection and attention to non-pathogen contaminants, such as spores or other microorganisms in the samples, are necessary. Research guidelines and policies also ought to be designed to allow legitimate invest...... research in this arena has focused on identifying reactions at the maternal-fetal interface in the placenta. Adrian Erlebacher and colleagues, from Harvard School of Public Health, have now, however, identified new means by which maternal immune activation can lead to pregnancy failure. Here, the authors prov...