Award winning researchers reveal potential new role for Glivec
...t a gene called the platelet-derived growth factor receptor B (PDGFB) was re-arranged in DFSP, involving a translocation between chromosomes 17 and 22. "It was intuitive to try imatinib in the disease because this translocation results in over expression of PDGFB and imatinib is an inhibitor for the PDGFB re...Marijuana use could cause tubal pregnancies
.... The researchers studied CB1, a "cannabinoid" receptor that binds the main active chemical for marijuana,... lacked the gene for the receptor, or in which the receptor was blocked, the embryo failed to go through the oviduct the tube leading from the ovaries to the u...Pollutant causes delayed flowering in plants
...sion. Also, he said, the researchers will seek the receptor that nitric oxide plugs into in plant cells -- an activation process like a key fitting a lock. "This study will validate the concept that nitric oxide is an important plant hormone," Pei said. "It provides the hard evidence that is needed to demonst...'Smart antibiotics' may result from UCLA research
...age that was able to change to recognize different receptor molecules on the surface of bacteria. The phage genome contains a series of genes, identified by Miller's team, that enable this fast-change routine. The researchers discovered that the phage's genome contains a "little genetic 'cassette' that functi...Scientists find nanowires capable of detecting individual viruses
...d to snag them and because each virus binds to its receptor for a characteristic length of time before dislodging -- leaving only a minuscule risk of a false positive reading. "The fact that a nanowire array can detect a single virus means that this technology is the ultimate in sensitivity," Lieber says. "Ou...Key stimulator of colorectal cancer identified
...and progression. Peroxisome proliferator-activated receptor d (PPARd), a regulator of cell survival, has also been linked to CRC. Dr. Raymond N. DuBois from the Department of Medicine at Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center in Nashville, Tennessee and colleagues investigate...Research suggests new avenue for stopping, preventing colon cancer
...ovided the first evidence that blocking a cellular receptor can inhibit the development of pre-cancerous colon polyps in mice. The research suggests a new avenue for stopping or preventing colon cancer, which kills more than 50,000 Americans each year, said the paper's senior author, Raymond N. DuBois, M.D., ...New way to protect brain from stroke damage
...t brain injury through the therapeutic use of NMDA receptor antagonists have been disappointing," they wrote. The new study pinpoints a new target underlying toxic levels of calcium in the brain, disclosing a potential new therapeutic target for stroke, the researchers added. Blockers of ASIC1a, either alone ...JCI table of contents September 15, 2004
.../) with mice that were deficient in either the PGI receptor (IP) or the TXA receptor (TP). These mice allowed the authors to examine the effect of loss of PGI or TXA action on atherosc...Picking prostanoids to provide protection
.../) with mice that were deficient in either the PGI receptor (IP) or the TXA receptor (TP). These mice allowed the authors to examine the effect of loss of PGI or TXA action on atheros...... Pathology at the University of Chicago examined a receptor on CTL cells called NKG2D that can be activated by stress-induced chemicals and has been linked to tissue damage. The researchers found that the immune stimulator IL15 induces a series of biochemical changes in the NKG2D signaling pathway that conver...A probable cause for high blood pressure identified - shows links with diabetes
...f Sciences identified the molecule that binds to a receptor (a molecule on the cell surface that triggers a re... "We have known for decades that when a particular receptor in the brain is over-stimulated, blood vessels constrict and blood pressure rises," said George Prel...Molecule awakens and maintains neural connections
...e synapses are silent, meaning they lack a type of receptor called AMPA receptors, which receive neurotransmit...ing with Dasm1 function drastically decreased AMPA receptor function. Their experiments also revealed that Dasm1 was responsible for "awakening" silent synapses...Sugar-coated sea urchin eggs could have sweet implications for human fertility
... protein called bindin connecting with the correct receptor in the plasma membrane on the surface of the egg. The sperm have to pass through a jelly-like coating, made up of complex carbohydrates, or sugars, to reach the egg surface. They react to the jelly coating by exposing the bindin protein. It was thou...Joslin President awarded medal from international diabetes organization
... Dr. Kahn's laboratory discovered that the insulin receptor is an insulin-stimulated enzyme with protein tyrosine kinase activity. His laboratory also demonstrated how insulin signaling is altered in insulin-resistant states, such as type 2 diabetes and obesity; the impact of genetics and environment on thes......n another apoptotic process -- that triggered by a receptor protein called TNF alpha, which also triggers the inflammation process. The researchers found that Compound 3 also switched on apoptosis in cells treated with TNF alpha. Thus, said Wang, Compound 3 might also be used as an anti-inflammatory drug. "A...Diabodies act as guided missiles targeted to mammary tumor growth
...ografts in mice. "The diabodies bound to the HER2 receptor produced by certain breast tumor cells." said Adam...enetrate these tumors," Adams said. Using the HER2 receptor protein on tumor cell membranes as a portal into the cells, the radioactive diabody gained access in...Essential smell gene may provide key to new insect repellents
... designing insect repellents." An anomalous smell receptor The sense of smell is very direct. In order for h...ene codes for each kind of receptor, and the Or83b receptor is unusual in two ways. First, nearly all the olfactory neurons in the fly have the Or83b receptor, ...Select research highlights from current AACR journals
...issue of Cancer Research: Aberrations in the receptor protein dystroglycan may lead to either muscular dystrophy or the development of carcinomas. Whereas several molecular defects in muscle disease have been characterized, little is known about such changes in carcinoma cells. Singh et al. identified m...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
...e multiple diseases because they use a very common receptor on the host cell membrane as an anchor point to attack. They target a receptor responsible for regulating one of the important human immune responses, known as Decay Acceleration ...