UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...and to interact with people looking at body-weight regulation from different perspectives," said Dr. Parker. "It will cause us to develop collaborations that we wouldn't have done before." In applying the research to humans, investigators will use participants from the Dallas Heart Study, an investigation of ca...UT Southwestern biochemist honored with NIH Director's Pioneer Award
...o receive the new award. His research involves the regulation of transcription factors, the proteins that switch...work on transcription factors to the study of gene regulation in the brain. One of his current projects has led to the discovery of genes that control the body's ...New molecular link key to cellular proteins involved in cancer progression, other diseases
...tem is one of the best-studied model of epigenetic regulation systems," said Zhang. PcG proteins function in protein complexes to repress transcription of genes that are likely to include key regulators of the cell cycle. The new study demonstrated that a gene normally silenced by the complex becomes switched ...Safety of isoflavones in dietary supplements targeted by Illinois initiative
...ors in breast tumors. They also will examine gene regulation in breast tumor systems, especially those adapted to changes in hormone responsiveness, adipose tissue and the brain. ...A novel, safer strategy for regulating gene expression
...hnologies, we will likely be able to 'tailor' gene regulation systems to respond to any drug or chemical," says ...de range of applications." Current methods of gene regulation usually involve a complicated three-part system that requires a "promoter" (a DNA sequence near the ...NSF announces six 'FIBR' awards to tackle some of biology's most challenging questions
... networks may serve as modular units for function, regulation and evolution -- Washington University, St. Louis (lead), Colgate University, Pacific Northwest National Laboratory, Saitama University (Japan) Separate profiles below provide more details on each of the awards, along with principal investigators, t...JCI table of contents September 15, 2004
... regulator of the Th1/Th2 balance through negative regulation of IL-12 and may therefore be a useful target molecule for improving CpG-DNAguided vaccination. TITLE: A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNAinduced IL-12 production and Th cell differentiation AUTHOR CONTACT: Tetsuya Matsuguchi...Researchers identify distinctive signature for metastatic prostate cancer
...ed suggesting that gene may be "a focal point of regulation in tissue regeneration and tumorigenesis." They also found they could convert low-metastatic cells into highly metastatic tumors by activating the Hedgehog pathway. "We actually found we could interconvert the two kinds of cell lines in mice," said ...Cell's gatekeeper for ammonia revealed in unprecedented detail
...ight differences in their channels and provide for regulation and localization of the ammonia transport, Stroud said. Using X-ray crystallography, the researchers determined the channel's structure down to an unprecedented resolution of 1.35 angstroms, or just over a 100-millionth of a centimeter, they reported......gner beak' must be made through differences in the regulation of cell behaviors," Chuong notes. Beaks are actually a collection of "facial prominences," says Chuong, and these prominences grow at varying rates during chick development to "compose a unique beak." But while early chicken beak development has been...Convulsions in worms mimic epileptic seizures
...worm a powerful model for unraveling the molecular regulation of epilepsy, a condition that affects two percent of the population. Guy A. Caldwell, coordinator of the Howard Hughes Medical Institute's (HHMI) Undergraduate Research Intern Program and assistant professor of biological sciences at the University o...JCI table of contents: 1 September, 2004
... TITLE: Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73deficient mice AUTHOR CONTACT: Jurgen Schnermann National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892, USA Pho...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...Kenneth M. Baldwin. AMP-activated protein kinase: regulation of metabolic and transcription processes in contracting skeletal muscle. Chair Neil Ruderman. Comparative biomechanics and muscle function in terrestrial vertebrates: in vivo studies. Chair Donald F. Hoyt and James Hicks. In addition to the form...The insect police: Why social insects punish cheating comrades
...unimportant--but it does mean that the harmony and regulation of reproduction in social insects is much more complex than expected from simple theoretical expectations based solely on relatedness....UCSD biologists develop 'super-endurance' strain of mice
...rcise and endurance in humans," says Johnson. "The regulation of response to oxygen in muscle is clearly critical in regulating the sensation of exhaustion and is important for avoiding muscle damage during extended exercise." The researchers note in their paper that high levels of mitochondrial enzymes and low...Researchers find clues about how antibodies specialize
...ficity of the mutation," Chaudhuri says. "If this regulation is impaired for some reason, then the B cell would incur a lot of random mutations and that might lead to tumors." The next step, then, is to figure out what sometimes goes wrong and allows the AID-RPA complex to go to the wrong regions, potentially...Breakthrough in understanding of hereditary disease of lymphatic vessels
...ritical for the formation of lymphatic valves, and regulation of the interaction between lymphatic endothelial cells and vascular smooth muscle cells. According to Professor Kari Alitalo, the senior author of the study, the insights gleaned into FOXC2 function may be applicable in the development of therapies ...In gene regulation, small is beautiful
...iet. Their role is crucial, because errors in gene regulation can lead to diseases ranging from diabetes to canc... factors or ATFs, could help scientists probe gene regulation and perhaps lead to new treatment approaches. Both natural transcription factors and their artificia...JCI table of contents, 16 August, 2004
... NFAT TITLE: Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation AUTHOR CONTACT: Riko Nishimura Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan Phone: 81-6-6879-2887; Fax: 81-6-6879-2890; E-mail: rikonisi@...Ovarian cancer sheds tumor suppression with loss of estrogen receptor
...rictive properties of this steroid receptor in the regulation of cell growth, death and motility. The loss of ER beta expression appears to be an important event leading to the development of ovarian cancer." Lazennec was joined in the ER beta studies by Aurlie Bardin, Pascale Hoffman, Franoise Vignon, Pascal P...