Tag: "repression" at biology news
Junk DNA yields new kind of gene
...y the complex. In the course of exploring how this repression
happens, Martens came across an even more surprising result. "The usual story when a gene is transcriptionally repressed is that RNA polymerase, TATA binding protein and a host of other factors associated with active transcription, will not be there,...
JCI table of contents, February 2, 2004
...sing microarray technology, the authors identified repression
of the enzyme SCD-1 as a mechanism of leptin action to improve fatty liver degeneration. These findings may have profound effects on the progression of leptin treatment strategies for metabolic diseases. TITLE: Site and mechanism of leptin action in ...
Translational repression in germline development
...t, in the fruit fly Drosophila, this translational repression
is achieved by a newly identified complex formed b...erior pole of the oocyte. This transcript-specific repression
is known to be mediated by the protein Bruno, which binds to the 3' UTR of oskar mRNA, but the under...
JCI table of contents, 15 October, 2003
...tion of HESX1/TLE1 interaction and transcriptional repression
in cultured cells. These results provide a striking example of a clinical disorder associated with the loss of repressor/corepressor interactions. Further study of HESX1 mutations should reveal crucial insights into the functional role of this gene i...
JCI Table of Contents, September 15, 2003
...y and histone deacetylasedependent transcriptional repression
mediated by the atypical homeodomain protein Hop AUTHOR CONTACT: Jonathan A. Epstein University of Pennsylvania, Philadelphia, Pennsylvania, USA. Phone: (215) 898-8731 Fax: (215) 573-2094 E-mail: email@example.com View the PDF of this art...
Discovering new regulators of the immune system
...regulate this protein. They then checked that this repression
was caused by the introduced gene and was not a side effect of the procedure. After three rounds of selection, 33 individual genes were cloned. Some of these were already known to play a role in the immune response, some already had unrelated functio...
UNC researchers identify protein crucial to gene silencing
... the modulation of gene expression - activation or repression
- throughout the genome. Studies at UNC and elsewh...e demonstrated both in vitro and in vivo that gene repression
is dependent on trimethylation."Zhang and his team are studying the biological significance of their...
Scientists identify molecular link between estrogen receptors and invasive growth in breast cancer
...d the MTA3 pathway failed to function, causing the repression
of other molecules, including E-cadherin. In clinical samples of breast cancer tissue, the scientists found that tumors containing estrogen receptors expressed MTA3 and E-cadherin, while tumors without estrogen receptor did not. "Our findings have ...
Newly identified molecules contribute to normal silencing of most human genes
...of a family of molecular complexes involved in the repression
of extensive sets of tissue-specific genes throughout the body. Additionally, one member of the family involved in repressing brain-specific genes in other types of tissues has been found to include a gene thought to be responsible for X-linked menta...
Scientists discover cause of common muscular dystrophy
...th the function of a protein complex that controls repression
of genes. This leads to over-activity of several genes that may play a role in the disorder. This type of genetic problem has never before been identified in a human disease. "For scientists, our research provides a starting point to think about t...
GM row delays food aid
...ld be stopped altogether if this form of political repression
continued. Now Harare has said that it doesn't want USAID's maize, despite the spectre of famine looming over six million of its citizens. "The position is that no GM foods are allowed in Zimbabwe," a spokesman at the Zimbabwe High Commission in Lon...
Researchers discover molecular 'switch' that tells body to store or burn fat
...ion the researchers asked was: to what extent does repression
of SCD-1 contribute to leptin's actions? They hypo... of leptin deficiency on energy expenditure. "The repression
of SCD-1 accounts for a significant proportion, perhaps even all, of the effects of leptin on energy...
The genetics behind hair loss
...s mediates thyroid hormone receptor-dependent gene repression
provides the first molecular insight into the role of Hairless in congenital hair loss disorders. This discovery represents a stepping stone upon which researchers can further delineate the genetic pathway of hair loss, and eventually design therapeu...
Fox Chase Cancer Center molecular biologist named V Foundation Scholar
... DNA is lost each time the cell divides due to the repression
of a specialized enzyme, telomerase, which is responsible for the replication of telomeric DNA. Thus, telomeres become shorter as we age. In most tumor cells, telomerase is active and telomere length is stabilized. The current hypothesis is ...
Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
...that FXR is one ofthe key regulators that controls repression
and further synthesis in the liverand increases the production of other proteins that transport bile acids in theintestine. "People can't live without bile acids as a way to rid the body ofcholesterol, so our work characterizing these orphan ...