Researchers discover why mutant gene causes colon cancer
... controls the conversion of dietary vitamin A into retinoic acid. If this process is impaired, colon cancer ca...we didn't know was that it converts vitamin A into retinoic acid, which is vital for normal colon cell development." Jones' lab had recently demonstrated t...Other highlights in the September 1 JNCI
...chemotherapy. Because fenretinide, a derivative of retinoic acid, targets a different molecular pathway--one that induces apoptosis, or programmed cell death--in neuroblastoma cells and is well tolerated, there has been interest in using fenretinide to treat neuroblastoma. In a study of fenretinide's activity...... They discovered that a family of genes called the retinoic acid receptor-related orphan receptor-a (Rora) cyc...use they are similar in amino acid sequence to the retinoic acid receptor genes, although they do not have the same function and do not bind to retinoic acid. (...XsalF comes to the fore in brain regionalization
...ding members of the Wnt and FGF gene families, and retinoic acid. While there is much evidence to support this model, a number of recent studies have indicated that the specification of the forebrain (an anterior structure, presumed to be induced by the initial signal in the activation-transformation model...Can a plant that acts like poison ivy cure prostate cancer?
...hers also tested TPA in combination with all-trans retinoic acid (ATRA), a vitamin A derivative previously shown to be effective in treating leukemia. "We knew that ATRA is an effective synergist with TPA in treating leukemia cells in the laboratory, but prostate cancer is a different situat...Novel therapies show promise against myeloid leukemia
... Leukemia (Abstract 486) All-trans retinoic acid (ATRA, found in vitamin A) and arsenic trioxi...olved in the control of apoptosis, is fused to the retinoic acid receptor alpha (RARa) gene in PML patients. The PML-RARa oncoprotein is present only in the le...Cancer prevention pioneer receives AACR/Cancer Research and Prevention Foundation Award
High-dose retinoic acid a vitamin A derivative can prevent the occurrence of new head and neck cancers in patients initially cured by surgery, radiation therapy or a combination of the two, according to more than two decades of research by Waun Ki Hong, M.D. He and ...March of Dimes awards $250,000 prize to pioneers in genetic research
...tiple receptor molecules that mediate signaling by retinoic acid (the active derivative of vitamin A) and its chemical relatives. His research has provided some of the most important contributions to our understanding of the consequences of vitamin A deficiency during prenatal development and childhood. A m...Researchers produce motor neurons from embryonic stem cells
...neurons. Two of the key signals, said Jessell, are retinoic acid, which converts mid-brain neural cells into s...ral fellow in Jessell's laboratory, began by using retinoic acid and other chemical cues to induce ES cells to differentiate into mid-brain-type neurons and the...Clonal human (hNT) neurons re-establish connection in rats with severe spinal cord injury
... the original cells. The cells can be treated with retinoic acid in the laboratory to prompt them into becoming fully committd, non-dividing neurons. Research in both animals and humans has shown that these hNT neurons do not revert to cancer cells. The USF team studied three groups of rats with severe SCI. ...Diabetes tied to altering of the heart's circadian clock
... for peripheral clocks, including glucocorticoids, retinoic acid and melatonin. In diabetes mellitus, the 24-hour cycle of many neurohumoral factors are abnormal. Plasma levels of insulin, leptin, glucocorticoids, growth hormone, thyroid hormone, glucose, and fatty acids, as well as sympathetic activity, a...Other highlights in the April 3 issue of JNCI
...tify oncogenes and tumor suppressor genes. TIG1, a retinoic acid receptor-responsive gene, was expressed in normal prostate tissue and in all 51 benign prostatic hyperplastic tissue samples but in only four of 51 malignant prostate tissue samples. After inserting TIG1 into a highly malignant prostate cancer ...Cancer killing gene found by Dartmouth researchers
...her tumor cells. It is activated by treatment with retinoic acid, a vitamin A derivative used in cancer therap...nds derived from vitamin A. The retinoid all-trans retinoic acid (RA) causes remissions in acute promyelocytic leukemia (APL), a rare, but lethal leukemia. This...Cardiovascular system holds a key to circadian clock
...reen to identify new proteins that interact with a retinoic acid receptor (the RXR receptor) when he found tha...protein cycled in a circadian pattern and that the retinoic acid receptors, when bound with vitamin A, modulated the rhythm of the clock in blood vessels. "...New light shed on vitamin A's role in the body's natural defenses
...e's team's paper. The paper is titled, "Effect of retinoic acid in lipopolysaccharide (LPS) and cytokine indu...Then, we gave them a normal physiological level of retinoic acid, the form in which vitamin A is active in the body, and observed an enhanced activity of the in...Vitamin A activates gene to guide kidney development
...idney and other organs. A derivative of vitamin A, retinoic acid, also is an important developmental signal. P... work by Dr. Mendelsohn and colleagues showed that retinoic acid receptors (RARs), the proteins required to bind and respond to retinoic acid signals, are neces......published papers that the enzyme CPY26 metabolizes retinoic acid, an essential derivative of vitamin A. Retin...ce in our understanding of the role and pattern of retinoic acid activity in the developing embryo. Further work to delineate the pathway of CPY26 action will ...UCSF researcher reports on protein therapy to reverse facial birth defects
... limb growth and lung development. Vitamin A, or retinoic acid, is also important -- excess doses during pregnancy, such as from the prescription acne medicine Acutane, can lead to very high incidence of holoprosencephaly and other head and facial defects. Helms and her colleagues discovered a few years ago...Schizophrenia possibly linked to early brain development
...in these genetic instructions;specifically, in the retinoic acid signaling pathway. Retinoic acid is the acidf...nmouse embryos that result from disruptions of the retinoic acid signalingpathway. He and other scientists also have reported craniofacial, heart and limbmalfor......ognize and respond to an essential nutrient called retinoic acid, which skincells make from vitamin A or retin...e U-M Medical School. "The inability to respond to retinoic acid triggers a cascade of biochemicalchanges that upsets the normal balance between healthy and dyi...