Chemical genetics identifies SARS inhibitors
Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) recently emerged as the causative agent of an atypical pneumonia. Within a year the virus infected more than 8000 people in 29 countries and claimed more that 900 human lives. Lack of knowledge about the novel virus and the absence of therapeutics were the primary reasons that the outbreak could not be contained and managed effic...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
Bethesda, MD (July 30, 2004) Researchers in New York City and Guangzhou, China applied the rapidly-developing carbohydrate microarray technology to study an inactivated SARS-coronavirus (SARS-CoV) vaccine and discovered autoimmunogenic activity of this newly identified human viral pathogen. ... ...Using glycan microarrays, the researchers characterized the carbohydrate binding activity of SARS-C...Genomic changes reveal evolution of SARS virus
Careful study of changes in the genetic make-up of the SARS virus through the recent epidemic has allowed researchers from China and the University of Chicago to bolster the evidence for the animal origins of SARS and to chart three phases of the virus's molecular evolution as it gradually adapted to human hosts, becoming more infectious over time. ......The earliest phase involved cases that a...SARS coronavirus part bird, part mammal: study
Severe Acute Respiratory Syndrome (SARS) is formed by a combination of mammalian and avian viruses, says a new study from the University of Toronto.... ...The study, published in the January issue of the Journal of Virology, sheds light on the SARS coronavirus, a deadly form of pneumonia caused by the same viral family as the common cold. By tracing its evolutionary history, researchers theorize...Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model
PITTSBURGH, Dec. 4 -- Research by scientists at the University of Pittsburgh School of Medicine and the Graduate School of Public Health (GSPH) in collaboration with colleagues at the Centers for Disease Control and Prevention (CDC) in Atlanta has shown that an adenoviral-based vaccine can induce SARS-coronavirus (SARS-CoV)-specific T-cell and virus-neutralizing antibody responses. ... ...The stu...Communication is key to successful U.S. SARS quarantine
LOUISVILLE, Ky.-Good communication with the public is key to a successful quarantine for severe acute respiratory syndrome, or SARS, says a report submitted today to the U.S. Centers for Disease Control and Prevention....... Public education and support for quarantine are essential to high rates of compliance with voluntary quarantine, and communication plays a key role, according to the report f...SARS virus can change quickly and unpredictably, analysis indicates
ANN ARBOR, Mich.---The SARS virus is capable of changing rapidly and unpredictably, which could present serious challenges for managing the disease and developing drugs and vaccines to combat it, research at the University of Michigan suggests. ... ...Ever since the SARS virus suddenly appeared in humans, scientists have been speculating about its origins and relationships to other, similar virus...McMaster University researchers race to SARS vaccine development
Hamilton, ON (October 1, 2003) -- Researchers at McMaster University have turned a corner in the race to develop a vaccine for severe acute respiratory syndrome (SARS).... ...A breakthrough has come with the work by professor Jim Mahony who cloned the gene that marks an important nuclear protein of the SARS virus. A research team at McMaster then inserted the nuclear protein gene into an engineer...SARS information for antiviral drug design released by Protein Data Bank
NEW BRUNSWICK/PISCATAWAY, N.J. -- The Protein Data Bank (PDB), an international resource for biomedical research with facilities at Rutgers, The State University of New Jersey, has released to the public a three-dimensional crystal structure of the SARS virus main protease enzyme. Its availability to medical researchers worldwide is crucial because this enzyme is considered the primary target fo...SARS pre-screening protocol developed for AACR Annual Meeting in Washington, D.C.
To provide an additional line of defense against the spread of SARS, the American Association for Cancer Research (AACR) has entered into an agreement with International SOS to pre-screen registrants and exhibitors from SARS-affected areas attending its upcoming Annual Meeting in Washington, D.C....... International SOS, the world's largest medical and security assistance company, will be pre-scr...Drug design expert sets his group's sights on SARS
Three days after the genome for the virus that causes SARS was released, biologists at The Johns Hopkins University identified a protein made by the virus that may provide a good target for drug development. Work is currently under way to produce the protein in recombinant form in sufficient amounts for drug design studies to begin....... The researchers found a protease, a protein essential to v...Public health measures can contain SARS, two modeling studies suggest
The SARS virus is contagious enough to cause a very large epidemic if left unchecked, but could nonetheless be controlled with rigorous public health measures, two research teams report. These results are being released today by the journal , published by the American Association for the Advancement of Science (AAAS). ...... Both teams used data about recent SARS cases to make projections about...Hospital disinfectant effective against Coronavirus (SARS virus) in decontaminating surfaces
Rockville, MD A strain of the Coronavirus has been identified as the cause of Severe Acute Respiratory Syndrome (SARS). Independent laboratory tests using EPA Guidelines have confirmed that Sporicidin Disinfectant kills Coronavirus within ten minutes. The tests concluded that Sporicidin is "an effective virucidal agent" against the Coronavirus on environmental surfaces. ......Studies have sh...... ......