Scientists at Scripps Research describe new strategy for the synthesis of glycoproteins
A team of investigators at The Scripps Research Institute and its Skaggs Institute for Chemical Biology in La Jolla, California has developed a new way of making glycoproteins-proteins with carbohydrates (sugars) attached.... ...Methods for making glycosylated proteins are important to scientists who want to understand the role of carbohydrates in protein structure and function, since the human...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
A team of researchers led by scientists at The Skaggs Institute for Chemical Biology at The Scripps Research Institute have solved the structure of a human protein called AGT that is known to interfere with the action of certain chemotherapy drugs. ... ...AGT repairs damaged DNA inside human cells. Cancer cells can use it to repair DNA that has been damaged in the course of chemotherapythus rende...Protein believed to control formation of memory identified by Scripps & UCSD scientists
Scientists at The Scripps Research Institute and the University of California, San Diego (UCSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder. ... ...They found that when the functions of normal CBP is suppressed in adult ro...22-amino acid bacterium created by Scripps scientists
A team of investigators at The Scripps Research Institute and its Skaggs Institute for Chemical Biology in La Jolla, California has modified a form of the bacterium Escherichia coli to use a 22-amino acid genetic code. ... ..."We have demonstrated the simultaneous incorporation of two unnatural amino acids into the same polypeptide," says Professor Peter G. Schultz, Ph.D., who holds the Scripps...Scripps scientists look deep inside sharks and their high-performance swimming system
Looks can be deceiving, the saying goes, and the same can be said of animals in the marine environment. To the casual observer, it would appear that the mighty great white shark and the common tuna don't have a lot in common. In fact, just the opposite is true, according to new research led by scientists at Scripps Institution of Oceanography at the University of California, San Diego, and their...Scripps research scientist wins 2004 Koch Prize
Professor Bruce Beutler, M.D., of The Scripps Research Institute has won the 2004 Robert Koch Award together with Professor Shizuo Akira of Osaka, Japan and Professor Jules A. Hoffmann of Strasbourg, France, the Robert Koch Foundation has announced. ... ..."I'm completely thrilled," says Beutler, Scripps Research professor of immunology. "I have never won such a prestigious award before, and I a...Scripps Research scientists find deafness gene's function
A group of scientists at The Scripps Research Institute, at the University of California in San Diego, and at the Oregon Hearing Research Center and Vollum Institute at Oregon Health & Science University have discovered a key molecule that is part of the machinery that mediates the sense of hearing. ... ...In a paper that will appear in an upcoming issue of the journal Nature, th...New approach limits damage after heart attack and improves survival, say Scripps Research scientists
A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.... ..."Immediately following a heart attack, blood vessels near the site of injury become leaky, causing fluid...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
A team of scientists at The Scripps Research Institute has described the cellular mechanism underlying the brain's response to alcohol, which suggests a possible method for treating alcoholism.... ......This work, published in the latest issue of the journal Science, ties together the effect of the brain peptide corticotropin releasing factor (CRF) with alcohol. Both appear to influen...Chemical that turns mouse stem cells into heart muscles discovered by Scripps researchers
A group of researchers from The Skaggs Institute for Chemical Biology at The Scripps Research Institute and from the Genomics Institute of the Novartis Research Foundation (GNF) has identified a small synthetic molecule that can control the fate of embryonic stem cells.... ...This compound, called cardiogenol C, causes mouse embryonic stem cells to selectively differentiate into "cardiomyocytes,...Structure solved by Scripps scientists shows one way that body controls gene expression
A group of scientists at The Scripps Research Institute has solved the structure of a protein that regulates the expression of genes by controlling the stability of mRNA -- an intermediate form of genetic information between DNA genes and proteins.... ..."Gene expression can be controlled at many levels, " says Scripps Research Professor Peter Wright, Ph.D., who is chairman of the Department...Scripps scientists say genetic mutation doesn't protect against HIV and plague
A group of scientists at The Scripps Research Institute have provided strong evidence that a popular hypothesis concerning the origins of a genetic mutation common among Caucasians of Northern European descent that protects against human immunodeficiency virus (HIV) is wrong.... ...The hypothesis suggests that the mutation conferred resistance against bubonic plague in the Middle Ages, much as i...Scientists at Scripps Research Institute describe structure of receptor on surface of 1918 flu virus
A team of scientists at The Scripps Research Institute has described for the first time the structure of a protein from the deadly 1918 "Spanish Flu" virus-- a virus that took more lives than World War I and became the largest and deadliest influenza outbreak in recorded history. Their work reveals some of the virus' deadly secrets. ... ..."Why was this so devastating an outbreak?" asked lead inv...Scripps Research receives $3 million anonymous donation
La Jolla, CA. December 15, 2003--The Scripps Research Institute recently received a $3 million gift to establish The Pearson Center for Alcoholism and Addiction Research that will combine biomedical research with clinical application to fight this deadly and costly disease. ...The donor, who wishes to remain anonymous, stated that the gift is "in memory of my parents whom I lost to alcoholism an...Scientists at Scripps discover a genetic cause for primary iron overload
Three studies to be published in the November/December issue of the scientific journal Blood Cells, Molecules, & Diseases describe the discovery of a genetic mutation that could be responsible for causing the metabolic disorder, primary iron overload, common among people of African descent.... ...Professor Ernest Beutler, M.D., who is chair of The Scripps Research Institute (TSRI) Department of M...Stepping way out: Scripps scientists watch clam feet elongate far from the shell
Scientists at Scripps Institution of Oceanography at the University of California, San Diego, have documented what they are calling possibly the most extreme case of animal structure elongation documented to date. In a paper published in the November 6 issue of the journal Nature, Suzanne Dufour and Horst Felbeck show that a clam from a certain species can extend its foot (clams have only one foo...Scripps scientists link ozone to atherosclerosis
A team of investigators led by The Scripps Research Institute (TSRI) President Richard A. Lerner, M.D., and TSRI Associate Professor Paul Wentworth, Jr., Ph.D., are reporting evidence for the production of ozone in fatty atherosclerotic plaques taken from diseased arteries.... ...Lerner is Lita Annenberg Hazen Professor of Immunochemistry and holds the Cecil H. and Ida M. Green Chair in Chemistry...Scripps team part of collaboration that reveals first ecological genomic 'blueprints'
A broad international collaboration of scientists has uncovered the first genetic blueprints of organisms critically important in the world's ecological makeup.... ...The genetic blueprints, or genomes, are publicized jointly in the August 13, 2003, online editions of the journals Nature and the Proceedings of the National Academy of Sciences. A group from Scripps Institution of Oceanography at t...Protein that fights bacteria and viruses cloned by Scripps scientists
Bacteria and viruses are completely different classes of pathogens, and not surprisingly the body uses completely different molecular "receptors" to detect them in order to mount an immune defense. ... ...Paradoxically, while the detection systems are different, the actual immune defenses the body employs to clear the system of viral or bacterial infection are much the same. As are the symptoms--...Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
A group of scientists at The Scripps Research Institute (TSRI) has designed a "hybrid" anticancer compound that physically combines the potent punch of a cancer cell-targeting agent with the long-lasting dose of an antibody. ... ...Much as a hybrid bicycle is a cross between two bikes--a road bike frame with mountain bike handlebars, for instance--this hybrid compound is a cross between two molec...Scientists at Scripps Research Institute address mysteries of ozone in the human body
In what is a first for biology, a team of investigators at The Scripps Research Institute (TSRI) is reporting that the human body makes ozone. ......Led by TSRI President Richard Lerner, Ph.D. and Associate Professor in the Department of Chemistry Paul Wentworth, Jr, Ph.D., who made the original discovery, the team has been slowly gathering evidence over the last few years that the human body pr...Scripps scientists discover new approach for treating 'misfolding diseases'
Professor Jeffery W. Kelly, Ph.D., and his colleagues in the Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) have demonstrated a new approach for treating "amyloid" diseases--particularly transthyretin amyloid diseases, which are similar to Parkinson's and Alzheimer's.... ...These amyloid diseases are caused by proteins misfolding int...Scripps scientists discover rich medical drug resource in deep ocean sediments
Although the oceans cover 70 percent of the planet's surface, much of their biomedical potential has gone largely unexplored. Until now....... A group of researchers at Scripps Institution of Oceanography at the University of California, San Diego, have for the first time shown that sediments in the deep ocean are a significant biomedical resource for microbes that produce antibiotic molecules....Scripps Institution researchers develop new approach for designing marine reserves
The culmination of hundreds of research dives, scientific analysis, and high-tech mapping software has led to a fundamentally new approach for designing networks of marine reserves. An effort led by researchers at Scripps Institution of Oceanography at the University of California, San Diego, and reported in the Dec. 6 issue of , could become a powerful new method for decision makers charged wit...Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
A group of researchers from The Scripps Research Institute (TSRI) have solved the structure of an enzyme that modulates central nervous system (CNS) functions such as pain perception, cognition, feeding, sleep, and locomotor activity....... The enzyme, described in the latest issue of the journal Science, is called fatty acid amide hydrolase (FAAH), and it breaks down certain fatty signaling mole...Scripps research gives tiny phytoplankton a large role in Earth's climate system
The ecological importance of phytoplankton, microscopic plants that free-float through the world's oceans, is well known. Among their key roles, the one-celled organisms are the major source of sustenance for animal life in the seas.... ...Now, in a new study conducted by researchers at Scripps Institution of Oceanography at the University of California, San Diego, our understanding of the signif...Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
A group of scientists at The Scripps Research Institute (TSRI) have developed a compound that could potentially be used as a new treatment for Gaucher disease, the most common genetic disorder affecting Jewish people of Eastern European ancestry. Although not tested in humans, the compound has shown great promise in human cell lines cultured from patients who suffer from the disease.... ...Patien...Kurt Wthrich of The Scripps Research Institute wins 2002 Nobel Prize in Chemistry
La Jolla, CA, October 9, 2002--Kurt Wthrich, Ph.D., who is Cecil H. and Ida M. Green Visiting Professor of Structural Biology at The Scripps Research Institute (TSRI) and a member of TSRI's Skaggs Institute for Chemical Biology; and Professor of Biophysics at Eidgenssische Technische Hochschule Zrich (ETHZ), Switzerland, was awarded the 2002 Nobel Prize in Chemistry today for applying the techniq...Scientists at Scripps Research develop new technology to map spread of malarial drug resistance
Scientists at The Scripps Research Institute (TSRI), Harvard University and the Genomics Institute of the Novartis Research Foundation have found a way to use a relatively new but readily available technology to quickly detect markers in the DNA of the most deadly type of malaria pathogen. ...... The technology could enable scientists and public health workers to identify the particular strain of...Scientists at the Scripps Research Institute discover how a plant times its flowering cycle
Two scientists at The Scripps Research Institute (TSRI) have described how a plant grown in their laboratory uses two sets of proteins to detect the seasons so that it can flower at the right time. And by tinkering with those proteins, the scientists were able to make the plant flower at will....... "We have demonstrated, for the first time, how plants can anticipate the seasons so that they can...Scientists at the Scripps Research Institute design gene-tipped tumor regressor 'smartbombs'
A group of researchers from The Scripps Research Institute (TSRI) have demonstrated what, in principle, could be a new way of treating cancer and several other diseases where angiogenesis occurs. Angiogenesis, the formation and differentiation of new blood vessels, is a crucial process in cancer, and, when blocked, improves a patient's prognosis....... In cancer-related angiogenesis, tumors devel...Scripps scientists find ignored species play key role in ecosystem interactions
New research at Scripps Institution of Oceanography at the University of California, San Diego, has shown that in nature, size may not necessarily matter as much as we think. ...... Scripps scientists Enric Sala and Michael Graham have produced a new study showing that so-called "intermediate" players in natural communities can often have as much and greater impacts than larger species. .........A disease that was once thought to be the most common genetic disorder of Europeans has now been shown by scientists at The Scripps Research Institute (TSRI) to be relatively rare....... In what was one of the largest DNA-based genetic epidemiological studies ever conducted, TSRI researchers working with the Health Appraisal Clinic at Kaiser-Permanente in San Diego examined the DNA and clinical...A potentially potent inhibitor of angiogenesis, the process whereby new blood vessels are formed from existing ones, can be found in one of the very molecules involved in the same process. This finding, made by two scientists from The Scripps Research Institute (TSRI), may lead to new therapies, as abnormal angiogenesis is the leading cause of vision loss in the United States.... ...In the curren...Simultaneous reports by two teams at The Scripps Research Institute (TSRI), led by Professor Paul Russell, Ph.D., and Associate Professor Clare H. McGowan, Ph.D., identify the "resolvase" enzyme that may be responsible for generating genetic diversity during sexual reproduction and could be a target for improved anti-cancer therapy....... In the current issues of the journals Cell and Molecular...La Jolla, CA, September 28, 2001 -- Professor Jeffery W. Kelly, Ph.D., and his colleagues in the Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) have uncovered a potentially useful strategy to treat the rare disease familial amyloid polyneuropathy (FAP) -- an approach that may be generally useful for intervention in other amyloid dise...Scientists at The Scripps Research Institute discover a previously unknown role for antibodies
La Jolla, CA, September 7, 2001 -- A team of scientists lead by Professor Richard Lerner, Ph.D., President of The Scripps Research Institute (TSRI) have discovered that antibodies have a novel catalytic abilityunique among proteinswhich could possibly mean they do more to protect our bodies than scientists had previously thought.... ...In the current issue of the journal Science, the team demonst...La Jolla, CA, September 7, 2001 -- A scientist at the Scripps Research Institute (TSRI) has published an x-ray crystal structure on the cover of the current issue of the journal Science that provides the first detailed glimpse of a membrane transporter protein, a finding that could be useful for improving cancer therapy and fighting antibiotic-resistant bacteria.... ...Antibiotic-resistant bacter...Scripps chemist wins national award for neurodegenerative disease research
What we do is design and utilize small molecules to change the course of biology, said Kelly, a chemistry professor and vice president of the Scripps Research Institute in La Jolla, Calif. In particular, we work to prevent neurodegenerative diseases simi...Scientists at the Scripps Research Institute find a way to block prions that cause mad cow disease
La Jolla, CA, August 16, 2001 -- Scientists working at The Scripps Research Institute (TSRI) and at the University of California, San Francisco, have published a paper in the current issue of the scientific journal Nature that describes an antibody that clears prion infection in cell culture. This finding may point the way to a treatment for mad cow disease and its human equivalent.... ..."[The a...