Researchers Pinpoint Site For Petit Mal Seizures In Brain
...apse into sleep." To determine where in the neural signaling process the defect lies, Caddick measured the function of GABAb receptors at the junction between nerve cells where signals are transmitted from one nerve to the next. She showed that GABAb receptors that receive signals are normal in the mouse thala...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
...he journal Cell,describes an entirely new cellular signaling mechanism -- the attachmentof nitric oxide (NO) to...that humancells also use NO molecules as a genetic signaling mechanism. "It appears that life uses NO ubiquitously," said the study'sleader, Dr. Jonath...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
...he journal Cell,describes an entirely new cellular signaling mechanism -- the attachmentof nitric oxide (NO) to...that humancells also use NO molecules as a genetic signaling mechanism. "It appears that life uses NO ubiquitously," said the study'sleader, Dr. Jonath...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
... "While this discovery is clearly important in the signaling processes,we have a long way to go in understanding exactly how it functions,"Casey said. "When we understand that, we will be in a better positionto design selective and specific inhibitors or enhancers of the process."...Medicinal Leech May Offer Clues To Neural Regeneration
...at in recent years has been recognized to act as a signaling molecule in vertebrates, including humans. As a signaling molecule, nitric oxide sends chemical messages to other molecules, setting up a chain of command to ...New Sensor Provides First Instant Test For Toxic E. coli Organism
...bone underlying this surface is the color-changing signaling system described by Bednarski and Charych. The Biomolecular Materials Program focuses on adapting nature's biologicalsystems to problems outside the living organism. In this case says Stevens, "Wehave made synthetic surfaces that mimic the un...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
...e crystalstructure of Src. In the cellular signaling event known as signal transduction, proteins clust...ese modular units, Src homology (SH)domain 2, is a signaling molecule that enables interactions and containsdocking units. Normally, Hck, like the other members ...New Study Shows Steps Leading To Colon Cancer
... and on human cells elsewhere has identified a key signaling mechanism required for normal embryonic developmen... potential drugs which might turn off or block the signaling pathway that leads to tumors," he said. Fruit flies are far more important in biology and medicine...Cell-Membrane Proteins Appear To Play Key Role In Squid's Swiftness
...illy, who studies membrane-channel proteins in the signaling of nerveand muscle cells, was surprised by the findings: "I was trained tothink sodium channels were all big and fast. It was difficult to think anythingas noble as a sodium channel could have anything to do with sluggardly behavior,even in slugs." ...Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
...ingto genetically engineer a protein to build in a signaling function, whichis called a "reporter." The group "borrowed" a protein from E coli bacterium thatsenses the presence of maltose, a disaccharide sugar molecule that thismicrobe sometimes feeds on. Using advance computer systems, they studie...Scientists Bridge Gap In Cell Communication
...ve events in cells. Studying a well-known signaling protein called MAD, UW-Madison geneticist Allen La...ing advantage of the well-studied process by which signaling governs wing growth. "We've shown that the MAD protein is a direct regulator of target gene transcri...Research Team Discovers Key Gene For Telomerase Enzyme In Humans
... is thought to act asa molecular clock of sorts by signaling the cell to stop dividing afterrepeated cell divisions. But the telomerase enzyme counteracts telomere shortening by addingDNA back onto the chromosome ends, he said. Normal cells do not containtelomerase, and their telomeres shorten with ea...Female Fireflies Lure Males For Defense Chemical
...niversity chemical ecologists have discovered, the signaling females are of a different genus, Photuris, and they're not especially interested in courtship. Rather, the femmes fatales fireflies are luring males close enough to eat them. The males contain defensive chemicals that females need to repel predator...ACS Aids Cornell Vet School Cancer Research
...Hs, that is a "biological switch" in growth-factor signaling pathways. By determining the three-dimensional st...Cornell researchers hope to explain more about the signaling process and to aid in the identification of new drug targets. The Casey study examines a com...Mathematics Reveals New Pattern Of Brain Cell Activity
... way.” The researchers looked at inhibitory signaling -- when neurons communicateby chemically suppressi...ssing other cells. Scientists observed inhibitory signaling amongbrain cells in the past, but assumed it couldn’t produce the smoothwaves that mark synchro...Molecular Defect Could Be Mysterious Cause Of Blood Disorder
...ia vera patients were much less active orshowed no signaling at all to thrombopoietin in contrast to thrombin. Theresponse to thrombopoietin was found to be due to the presence of an abnormalityin the thrombopoietin receptor. A similar abnormality was observed in themegakaryocytes, the bone marrow cells that...Tiny Worm Reveals Workings Of Suspected Tumor Protein
...ccells tend to become neurons by default. Specific signaling events are necessaryto coax cells to mature into other cell types, much like it takes activesignaling to dissuade a prospective male embryo from its inherent tendency tobecome a girl. Moreover, a separate line of investigation is converging w...MSU Scientists Eavesdrop On Bacterial
... Engineering. Today's report of cell-cell signaling represents the first words in whatmay be a large chemical vocabulary dictating how bacteria do what they do inbiofilms and why. The paper is the first to report on bacterial communication inbiofilms, said Davies, although bacterial communication in o...Human Bone Disorder Reproduced In Mice
...pes may link together, either physically orthrough signaling molecules, to alter normal bone metabolism. Bianco and Gehron Robey hope to use the animal model to develop novel, effective therapies for the bone lesions of McCune-Albright syndrome, currently a majortherapeutic challenge. They also plan to use the......b says. Improved understanding of chemical signaling cascades in the endocrine system could lead to better medical therapies -- perhaps even gene therapy -- for conditions such as hypertension and heart attack, predict McCobb, an assistant professor of neurobiology and behavior, and Xie, a postdoctoral...