Tag: "simplex" at biology news

Northwestern Scientists Discover How Herpes Simplex Virus Infects Cells

... a human protein that provides a pathway forherpes simplex virus to infect lymphocytes, important cells of th... is not only the first "portal of entry" forherpes simplex virus to be identified, but is also a previously unknownmember of an important family of cell surfac...

Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine

...ays Dr.Federoff. The physicians used a herpes simplex virus -- the same onethat causes blisters and cold... most people and animals. It takes the herpes simplex viral amplicon vectors onlyabout 20 minutes to slip genes into cells, Dr. Federoff says,much faster ...

Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine

...," says Dr. Federoff. The physicians used a herpes simplex virus -- the same one that causes blisters and col...ic to most people and animals. It takes the herpes simplex viral amplicon vectors only about 20 minutes to slip genes into cells, Dr. Federoff says, much faste...

Gene Therapy Trial Takes Aim At Deadly Brain Cancer

...involves inserting a gene derived from a herpes simplex virus into glioblastoma tumor cells. When intro...d mouse leukemia virus that includes the herpes simplex gene for thymidine kinase. This genetically engineered “composite” virus will infect ne...

Harvard Medical School Researchers Present Atomic Structure Of DNA-Replicating Enzyme Widely Used In DNA Sequencing

...ncluding theAIDS drug AZT and drugs against herpes simplex virus, inhibit DNA polymerase. Inaddition, this work may guide the development of better reagents for DNAsequencing--highly sought-after products in this age of the Human Genome Project. This is the largest protein complex ever to be revealed by the ...

New Company To Turn UNC-CH, Army Inventions Into Improved Vaccines

...suchas HIV -- the virus that causes AIDS -- herpes simplex virus and human papillomavirus. Dr. Robert E. Johnston, UNC-CH professor of microbiology and immunologyand one of the company's founding scientists, said the technology has obviousadvantages over other vaccine methods. The new technique is ef...

UF Researchers Identify Virus That May Cause Epidemic Disease In Sea Turtles

...netically similar but not identical tohuman herpes simplex virus 1 and 2 and varicella zoster virus,which causes chickenpox, Klein said, but researchers do not believethe virus can transmit the disease to people. "Isolating a virus is a major first step in incriminatingan infectious agent as a cause...

Study Links Viruses And Vascular Diseases

... in AIDS patients. Theextremely common herpesvirus simplex 1, the cause of cold sores, is a moredistant relative. "These viruses are now legitimate candidates for initiatinghuman vascular disease," Virgin says. "It's a possibility that deserves furtherinvestigation." Despite repeated efforts, researchers hav...

New Gene Therapy Technique Results In 60 Percent Tumor Regression Rate

...ls: They stimulated cellular expressionof a herpes simplex virus-thymidine kinase (HSV-TK) gene in tumors, then treatedthe tumor-bearing animals with the drug ganciclovir. In their studies, 30percent of the tumors were permanently eliminated. While similar tests of the HSV-TK/ganciclovir protocol ha...

New Model Makes It Possible To Predict Emergence Of Antiviral Drug Resistance

...ynamics of drug-sensitive anddrug-resistant herpes simplex virus in the general population, was designed topredict how much drug resistance could be expected to emerge over the next 50years if treatment rates increased, and to identify the key factors that woulddetermine the emergence of drug resistance. Usi...

New Herpesvirus Receptor Discovered That Allows Entry of Both Herpes Simplex-1And -2 And Animal Herpesviruses Into Human Cells

...fferent types of herpesvirus, including two herpes simplex viruses(HSV), to infect human cells. This...mmunology at the Medical School. Herpes simplex virus is highly prevalent in humans, in part because itcan establish latent infections in nerve cell...

Common Anti-Viral Medication Prevents Severe Eye Herpes

...vere forms of the eye disease, thecausative herpes simplex virus persists between disease episodes in the ner...ns. Herpes of the eye is usually caused by herpes simplex I virus,which also causes fever blisters or cold sores around the face and mouth. The study, which w...

Social Stress Causes Dormant Herpes Virus To Resurface In Mice

...y social reorganization triggered a dormant herpes simplex virus type 1 (HSV-1) infection. HSV-1 causes cold sores around the mouth and on the face in humans and genital disease. Glaser conducted the study with David...

University Of Chicago Professor Wins $50,000 Bristol-Myers Squibb Award For Distinguished Achievement In Infectious Disease Research

...izman, Sc.D., the world's leading expert on herpes simplex virus(HSV), and Joseph Regenstein Distinguished Service Professor in the departmentsof molecular genetics & cell biology and biochemistry and molecular biology atthe University of Chicago , has been namedthe winner of the eighth annual Bristol-Myers...

Science Announces Top Ten Research Advances Of 1998

...rders and infections such as Lymedisease or herpes simplex virus 1. In some people these infections turn intodebilitating long term illnesses even though the bacteria or virus that causedthe infection is long gone. Researchers have now confirmed earlier suspicionsthat the infection causes the immune system t...

Topical Agent Found To Kill Papillomavirus

...ncluding human immunodeficiency virus (HIV),herpes simplex virus type 2 (HSV-2) and human papillomaviruses (HPVs). Theseviruses cause AIDS, genital herpes and genital warts, respectively. "This is a major step toward our goal of producing a practical,non-toxic, inexpensive, discreet product which wom...

Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertex's Investigational IMPDH Inhibitor VX-497

...tomegalovirus, respiratory syncytial virus, herpes simplex virus type 1, parainfluenza-3 virus, and Venezuelan equine encephalitis virus. Preliminary data suggests VX-497 may be more potent than ribavirin against bovine viral diarrhea virus and as potent as ribavirin against dengue virus. In another study, u...

Scientists clear hurdle in effort to destroy experimental brain cancers with viruses

...g this responseallowed a modified strain of herpes simplex virus to reach the brain tumors, enabling it to attack--and in some cases destroy--thetumors. The study is published in the August Nature Medicine. "This treatment is more efficient than anything we have done before," says Chiocca, who led the study....

New molecular clues to herpes control

...l Hill mayhave identified a new way to halt herpes simplex virus in its molecular tracks. The findings, though still too basic for clinical use, shed new light on howthis stubbornly persistent virus reproduces itself within nerve cells and maysuggest possible ideas for designing therapies aimed at specific m...

Novel antiviral drug concept targets number of human viruses

...ial support of their life cycles. Using the herpes simplex virus (HSV) as model target, the Penn team discovered that by inhibiting a particular set of cellular enzymes upon which the virus depends they can successfully block all viral activity while causing the host cells no ill effects. "To date, all ef...

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