Eviction From Scum Home Makes Disease-Causing Microbe Vulnerable
...film. The gene, lasI,works as a master switch that spurs other genes to action andcause disease. The team showed that by knocking out that gene,the bacteria form only wimpy biofilms that are vulnerable toattack by detergents. Instead of aligning themselves in fancymushroom- and pillar-shaped structures as ...Master Molecule Forms Brains In Frogs And Elbows In Mice
...d no joints and, in addition, exhibited occasional spurs in the cartilage that makes up such tissues. In addition to the likely clinical implications of the work, of particular interest to scientists is the way Noggin influences joint formation (and probably all of its physiological roles in different orga...Autoimmune Diseases May Be Triggered By Cells From Your Mother
... can arise when a triggersuch as a viral infection spurs the foreign cells to begin attacking their host.This reaction disrupts the host's immune system so that it joins the attackagainst the body's own tissues, she believes.......n similarly behaving individuals vary in body size spurs thesearch for genetic, as well as environmental, causes of obesity. In the Octoberissue of Genome Research, Robert Hegele (University of Western Ontario), PhilipConnelly (University of Toronto) and colleagues have discovered that variationsin a gene...Mother nature cleans up human-made mess
...ls - a component of raw sewage and a nutrient that spurs algae growth - and compared their results with data from an earlier 1970s study done during the peak of activity at the base. They found that the phosphorus levels have declined sharply since 1972, which is in keeping with the decreased population of......e story in the X chromosome. Finally, this study spurs researchers to ask if infertility can be inherited, just like color blindness and hemophilia. Previous research from the Page lab had suggested that the genetic defect underlying low sperm count can be inherited by sons from their fathers when infert......, as that reaction is called, is the key step that spurs translation, or protein synthesis in cells, but scientists probing how genes first came to generate life as we know it have been puzzled about how that crucial step came to be taken, without a catalyst to trigger it. "Using an in vitro version of D...'Flap' on protein suggests new therapies for autoimmune diseases
...is an important regulator of the immune system. It spurs B cells to mature and produce antibodies, one of the bodys major defense mechanisms. Mice engineered to make too much Tall-1 develop lupus-like symptoms. People with lupus and rheumatoid arthritis have been shown to have high levels of Tall-1 in thei...Study pinpoints mechanism behind tamoxifen side effect
...In breast cells, however, a coupling with estrogen spurs cell growth increasing the chances theyll become cancerous whereas a coupling with tamoxifen or raloxifene restrains their growth. In uterine cells, estrogen and tamoxifen have the same growth-promoting effect, whereas raloxifene does not. The chal...Loss of lean body mass in HIV-infected men linked to immunological processes
...or-a by peripheral blood mononuclear cells (PBMC), spurs cachexia and increased resting energy expenditure (REE) and protein catabolism, without weight loss. Since rheumatoid arthritis is a system disease like HIV infection, the research team sought to link HIV infection to this process that causes cachex...NIGMS and NSF grants join math and biology
...ector of NIGMS. Other initiatives in which NIGMS spurs mathematicians, computer scientists, physicists and engineers to apply their quantitative expertise to biology are described at http://www.nigms.nih.gov/funding/complex_systems.html . NIGMS also recently established a Center for Bioinformatics and ...Binding studies suggest drug development strategy for lupus
...is an important regulator of the immune system. It spurs B cells to mature and produce antibodies, one of the body's major defense mechanisms. Mice engineered to make too much Tall-1 develop lupus-like symptoms. People with lupus and rheumatoid arthritis have been shown to have high levels of Tall-1 in the...Missing link detected in insulin mechanism
...g how insulin impinging on the outside of the cell spurs these transporter-containing vesicles to move toward and fuse with the cell surface. It involves linking up two specialized areas of cell biology: cell signaling and membrane trafficking. Insulin binding to its receptor on the outside of the cell ...New growth-stimulating cue identified for nerve cells
...Jeroen Pasterkamp, Ph.D., found that semaphorin-7a spurs axon growth by hooking onto proteins called integrins, which are found on nerves and many other cell types. Among their many roles, integrins (pronounced IN-teh-grins) help control cells' interactions with their surroundings by capturing chemical sig...Dartmouth study advances prion disease research
...enetic information to replicate. No one knows what spurs conversion of a normal prion protein to a disease-causing counterpart. Supattapone, with coauthors Nathan Deleault and Ralf Lucassen, has discovered that RNA may be a catalyst for transformation. "It has been well proven that nucleic acids, includ...Gene links hereditary intestinal disorder with stroke danger
...s linked to juvenile polyposis, called MADH4, also spurs the vessel defects characteristic of HHT. In HHT patients, some arteries shunt blood directly to veins, rather than diffusing the flow through capillary networks. The high-pressure blood flow in such junctures makes the vessels susceptible to breaks ......PKA molecule. This interaction, the team believes, spurs the growth of tumor cells in ways that hadn't previously been known. "To better understand how things go wrong in cancer, you need a better understanding of the normal signaling process when things are going right," says Simeone, an associate profes...