Martin Saunders to receive the James Flack Norris Award
...steroids. The approach Saunders took was to create stable solutions of these normally highly reactive species, so that they could be studied by NMR. This allowed him to discover the detailed mechanisms and rates of very rapid rearrangement reactions of the cation intermediates. Saunders received his Ph.D. ...Amyloid fibers sprout one step at a time
...rage the rapid formation of a relatively inert and stable amyloid might deplete the toxic oligomers and therefore be beneficial," he said. Weissman emphasized that basic studies of amyloid formation must be extended beyond the yeast prion model before the monomer-addition mechanism can be considered a gene...Two Virginia Tech energy-related inventions win R&D 100 awards
...ports in the R&D 100 entry that Battellion remains stable in the fuel cell's highly oxidative environment, is easy to manufacture, using some commercially available materials and new processes, and is highly conductive, to name a few advantages. McGrath's group has been developing fuel cell materials for a...Molecular staples shape a cancer killer
...ed SAHB's properties, they found that it assumed a stable alpha-helical shape, bound to the right protein to trigger apoptosis, and resisted degradation by proteases. They also found that SAHB specifically triggered the cell's power plants, the mitochondria, to release a protein that participates in launchi...Chernobyl study: Risk of thyroid cancer rises with radiation dose
...'s senior administration for helping him establish stable working relationships with their overseas colleagues. "The incredible support and flexibility of the center, especially in the early stages, really made this happen. That can't be overstated," Davis said....Modest climate change could lead to substantially more and larger fires
...Kenzie says. "The losers are the ones needing more stable environments."...How an insidious mutation fools DNA replication
...h this mispair, and that could potentially lead to stable incorporation of a lethal mutation," said Beese. In further analyses, Hsu confirmed that bacterial polymerase would behave just as did the human polymerase in preferring to incorporate the mismatch and failing to recognize it. Also, they found, if th...Researchers improve detection of diverse anthrax strains
... were highly stable. Only one SNP was not entirely stable across the entire study, which means that diagnostic and forensic tests developed using this information will have extremely low false positive, or misidentification rates, a crucial criterion for advanced tests. False positives from anthrax environm...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...In contrast, the "head" of the VP4 protein is very stable at room temperature and easy and relatively cheap to produce, Dormitzer says; he believes the same is true of the "body." A vaccine based on these proteins could be very practical, especially for developing countries where rotavirus causes the most s...Listen up! Mice may hold key to restoring human hearing loss
...ed from the mouse inner ear to establish long-term stable cell lines. This is the first step toward the ultimate goal of creating implantable human hair cells that will grow happily; eventually repairing damaged hearing and restoring balance. Corwin, a neuroscience professor from the University of Virgin...No longer just for biology, RNA can now be built into 3-D arrays
... of connected RNA building blocks. The arrays are stable and resistant to a wide range of environmental conditions, such as temperature, salt concentration, and pH." Peixuan Guo From experts at NSF: "The discovery of this viral RNA machine is quite remarkable and provides yet another example of the flexib...Scientists reinvent DNA as template to produce organic molecules
... strands used by Liu's team are large enough to be stable at room temperature and in theory can encode thousands of individual small organic molecules. Liu's co-authors are Zev J. Gartner, Brian N. Tse, Rozalina Grubina, Jeffrey B. Doyon, and Thomas M. Snyder, all of Harvard's Department of Chemistry and Ch...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...d showed rapid and robust improvements, which were stable over an extended period post-therapy. The study, ...on within the host myocardium, can contribute to a stable beneficial outcome on contractile function and ventricular remodeling in the infarcted heart." Going...When is a mouse like a test tube?
...taining molecules that react with azides to form a stable phosphorous-nitrogen compound. Both types of molecules have shown no harmful effects in the body, based on use of the AIDS drug AZT (azidothymidine) and phosphine-gold compounds for treating arthritis. Bertozzi figured that if she could attach an az...The first engineering of cell surfaces in living animals
...he ligation product formed from these compounds is stable under physiological conditions. The trick is to get the azide half of the reaction to show up on cell surfaces. In cell cultures, this is done by diffusing into the cells a precursor, containing the azide group, of a commonly expressed form of oligo...Infants sighs may 'reset' breathing regulation mechanism as well as help lungs develop
... The data showed that a "highly regulated and stable negative feedback loop system exists in healthy infants and that sighs represent a mechanism for improving the memory associated with neuro-respiratory control of breathing." They explain that prior to a sigh, infant breathing seems to become more r...News tips from the Journal of Neuroscience
...l environment, creating a map that tends to remain stable on reentering that space. However, even within a single environment, place cells can change their preferred firing locations, presumably to convey contextual details. This week, Moita et al. show that fear conditioning can induce such a re-mapping pr...Manatee population rising in some regions, likely stalled or declining in others
...large enough that it is possible the population is stable or slightly declining. In the Southwest region, the estimated population growth rate is negative (1.1 percent per year); however, the margin of error in this estimate is larger than in the other regions. "The estimates for the Atlantic and Southw...Activated signaling pathway may predict lung cancer patients' response to gefitinib
...(which includes complete and partial responses and stable disease), and time to progression than patients with P-Akt negative tumors. There was no difference in outcome according to MAPK phosyphorylation (P-MAPK) status. P-Akt positivity, but not P-MAPK positivity, was associated with a reduced risk of dise......e proverbial heap, the Gulf may have entered a new stable phase marked by the presence of expansive kelp beds and the near absence of sea urchins. These findings could signal the likelihood of significant biological changes in other heavily fished parts of the world's oceans as well. The authors of ...