Tag: "susceptibility" at biology news

New study indicates arsenic could be suitable as first-line treatment in type of leukaemia

... and the blood, resulting in anaemia, bleeding and susceptibility to infections. It occurs in people of all ages, although it is more common in older people. The five-year survival rate for patients receiving the current optimum treatment of chemotherapy plus ATRA (All Trans-Retinoic Acid a vitamin A-based substan...

Gene clusters predict atherosclerosis severity, susceptibility

...n the inflammation process, while those related to susceptibility tend to mediate cellular responses that occur prior to the inflammatory process. "While the methods we used to identify these genes do not have immediate clinical applications, they do play an important role in identifying genes for further...

AAAS expert panel calls for voter-system research and reform

... the error rates ofexisting technologies and their susceptibility totampering and fraud; trade-offs between opensource and proprietary software in electronicvoting systems; the impact of ballot design onvoters' understanding of the process; and studiesof security in technologies similar to votingmachines, such as A...

NSF awards 22 new projects for plant genome research

...etics plays in plant development, metal tolerance, susceptibility to diseases and other economically important characteristics. NSF's PGRP is part of the National Plant Genome Initiative established in 1998 as a coordinated national plant genome research program by the Interagency Working Group on Plant Genomes of ...

JCI table of contents September 15, 2004

...ostanoid Promotes Renal Pressure TITLE: Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP AUTHOR CONTACT: Fumitaka Ushikubi Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, Japan Phone: 81-166-68-2362; Fax: 81-166-68-2369; E-mail: ush...

TANGO: towards faster prognosis of Alzheimer's and Parkinson's diseases?

... TANGO - a statistical method that can predict the susceptibility of proteins to sticking together. Thus, for the fi...ctural characteristics in proteins determine their susceptibility to sticking together. Using this information, Joost Schymkowitz and Frederic Rousseau have develope...

The impact of genetic variations on the treatment of early rheumatoid arthritis

...r genetic marker in the HLA region associated with susceptibility to RA (the so-called shared epitope), as well as genetic variants in the TNF gene region. Results of genetic testing were then correlated with treatment responses. Among patients treated with standard-dose etanercept, those with two copies of the sha...

Hunting illusive signs of natural selection

..., but one of the genes, TRPV6 might be involved in susceptibility to aggressive prostate cancer and since there is a large difference in the prevalence of prostate cancer between the European- and African-American populations, TRPV6 may be the selected gene. TRPV6 and TRPV5 are involved in calcium absorption. Nort...

Adaptive changes in the genome may provide insight into the genetics of complex disease

...s were scarce, but isnow detrimental and increases susceptibility to diseases such as diabetesand obesity. "The env...ed turn out to betrue for some genes that increase susceptibility to complex diseases. Ifthis is true, finding genes that have been affected by natural selection maya...

Rising childhood leukaemia incidence prompts conference

...dicines in pregnancy and delayed transgenerational susceptibility through the germline.(ends) Notes to Newsdesk: The conference is taking place at Church House, Dean's Yard, Westminster, London, from Monday 6 September to Friday 10 September. All sessions of the conference are open to the media and there is a staff...

Recent evolution at a single gene may have brought down heart disease risk in some human groups

...had natural selection not shifted the frequency of susceptibility genes over the past few tens of thousands of years...s, they showed that the variation in heart disease susceptibility is partly attributable to a so-called mutational "hotspot" that has naturally occurred in MMP-3's re...

Convulsions in worms mimic epileptic seizures

...uite possible that other gene mutations might show susceptibility to convulsions in worms," said Caldwell's undergraduate co-author Locke, who, with support from HHMI and a National Science Foundation Career award, has developed a computer database of candidate epilepsy genes to test in the worm model. Named to USA...

Scientists discover proteins involved in spread of HIV-1 infection

...ino acids which it uses to recruit the human tumor susceptibility gene 101 (TSG101). The virus then uses TSG101 to take control of the protein sorting and vesicle formation machinery and use it for its own purposes. Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two o...

Streptococcus infects humans by thwarting blood clotting

...rmal and transgenic mice, they both showed similar susceptibility to infection. In another experiment to demonstrate...mong humans could partially explain differences in susceptibility to certain infection in different people. Thus, he said, his laboratory is exploring the genetic var...

2nd media alert First Scientific Conference on Childhood Leukaemia

...etus of damaging agents, delayed transgenerational susceptibility through the germline, the presence of pre-leukaemic cells in babies that make them vulnerable to environmental triggers, and so on. The conference will also be told of the latest research relating to the precautionary principle, which questions wheth...

Penn scientists identify novel pathway in aneurysms

...have shown in an atherosclerotic animal model that susceptibility for developing aneurysms increases significantly when an inflammation pathway important in asthma is activated. Mice without the inflammation gene were protected from aneurysms. Colin D. Funk, PhD, former Professor of Pharmacology and Medicine, and ...

Heartless worms hold clues to cardiac arrhythmias, sudden death

...y is very interested in finding ways to screen for susceptibility to acquired long QT syndrome and in discovering ho...modulating factors -- are influencing HERG channel susceptibility to drug block. That's where the worm came in. "This paper is really a proof of principle of the uti...

Study narrows search for genes placing men at increased risk for prostate cancer

...th in Bethesda, MD. "If we could identify men with susceptibility genes, we can target our surveillance to them and ...on, she noted, prostate cancers in men who possess susceptibility genes tend to be more aggressive--and more often fatal--than prostate cancers in men who are not gen...

Other highlights in the August 18 JNCI

... regions that are likely to harbor prostate cancer susceptibility genes. Prostate cancer is the second leading cause... disease, but no genes that confer prostate cancer susceptibility have been found to date. In an analysis of 426 families with histories of prostate cancer, Jeffrey M...

Tips from the journals of the American Society for Microbiology

...mine Gum Disease in Humans Genetics may determine susceptibility or resistance to the bacteria that causes periodon...iated with the pathogenesis, severity, and genetic susceptibility to human periodontal disease," say the researchers. In the study researchers compared gene expressio...

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