Washington University Licenses Its New Antibacterial Technology
...lueprint for the development ofnovel antimicrobial therapeutics and strategies," Hultgren says. E. coli is covered with hair-like structures called pili. The tips ofthe pili carry proteins that fit into receptors in the kidney or bladder lininglike keys into locks. Firmly anchored, the bacteria go about t...Hultgren Receives Prestigious Eli Lilly Award
...have a blueprint fordeveloping novel antimicrobial therapeutics and strategies," Hultgren says. Hultgren has received three other recent honors. In 1997, he was awardedan honorary doctorate from Umeå University in Sweden. Next summer, he will go tothe Medical Nobel Institute for six months as the re...Cystic Fibrosis Foundation Launches Innovative Therapeutics Development Centers
....3 years, CF remains fatal. Therefore, life-saving therapeutics must be developed. The mission of the Cystic Fibrosis Foundation is to assure the development of the means to cure and control cystic fibrosis and to improve the quality of life for those with the disease....Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
... anddevelopment of small molecule drugs to enhance therapeutics and safety profilesand to address unmet patient needs in cancer, women's and men's health and skindiseases, as well as osteoporosis, metabolic, cardiovascular and inflammatorydisease. This document may contain certain forward-looking statemen...Antisense Therapy Prevents Burkitt's Lymphoma In Mice
...ach to the treatment of disease using nucleic acid therapeutics orvectors." He adds that "the ability to turn off or correct individualdisease-causing genes, or to replace them at will in a patient's cells providesa powerful therapeutic intervention in genetic diseases. Gene-specific nucleicacid therapy ......ically advance the development of new vaccines and therapeutics designedto prevent and treat this widespread disea...ritical step in discovering anddeveloping targeted therapeutics and vaccines against HCV and HCV-induceddisease, and greatly increases our knowledge about the biolo......es." Idun Pharmaceuticals creates innovative human therapeutics with a primary focuson controlling apoptosis, or programmed cell death. In addition to its focus onsmall molecule inhibitors of apoptosis for applications in central nervoussystem disorders, cardiovascular disease, inflammation, and organ damage, Id......n the broadpotential of ribozymes for use as human therapeutics and other areas, includingthe identification of gene function and therapeutic target validation. RPI isdeveloping an anti-angiogenesis compound ANGIOZYME® that is in Phase I ClinicalTrials. The Company has also entered into a collaboration with...Novel Viral Vaccine Protects Aids In Animal Model
... is a privately heldcompany developing proprietary therapeutics based on recent scientific advancesin basal lamina and related technologies. The company's drug candidatesare directed against novel basal lamina extracellular targets involved indegenerative and invasive disease processes fundamental to diabetes and...Researchers Find How Two Cancer Genes Interact To Cause Malignancy
...signal, Nevinssaid. "The key to developing better therapeutics for cancer," said Nevins, "is usingthe information...gulate these activities opens theway to developing therapeutics that specifically target the abnormal function,leaving the normal functions alone," he said. Ot...Osiris Therapeutics Reports Key Findings in SCIENCE Verifying Existence of Adult Stem Cells
... the development and commercialization of cellular therapeutics for the regeneration and functional restoration of damaged or diseased tissue. Osiris has developed proprietary technology to isolate and greatly expand adult stem cells for their use as cell therapeutic products for the regeneration of tissues damag...Study Furthers Understanding Of Critical Alzheimer's Disease Gene
...oves true, it couldlead to significant advances in therapeutics research by showing us how tointervene before plaques form."...Immune Response To Hepatitis B Spares Liver Cells
...ne processes couldbecome an important focus of HBV therapeutics research." The authors conclude that by limiting HBV's vulnerability to T-cell attack, thesame noncytolytic process could be beneficial to the virus, and contribute topersistent HBV infection. "Indeed, both scenarios could even be operative in the sa...New Gene Holds Promise For Controlling Crohn's And Other Inflammatory Diseases
...covery willutilize LITAF to produce small molecule therapeutics which can be more easilyand economically used to treat chronic inflammatory conditions like Crohn'sdisease. The research leading to this discovery was supported by the National Instituteof Craniofacial and Dental Research of the National Institutes o...Experimental Staph Vaccine Broadly Protective In Animal Studies
...ion,and would therefore be logical targets for new therapeutics or vaccines,"explains Gerald B. Pier, Ph.D., who led the research team that developed the newS. aureus vaccine. The researchers found that although tissue from humans and mice infected with S.aureus contained a staph polysaccharide molecule known as ...Scientists image key steps in bacterial infection
...borating with a drug developmentcompany to develop therapeutics that will block the formation of bacterial piliand which therefore would be useful in the prevention and treatment of bacterialinfections in humans. Stefan D. Knight, Ph.D., associate professor of molecular biology, andpostdoctoral fellow Devapriya C...... TAPET, a drug delivery platform, and three cancer therapeutics (Promycin, Triapine and Sulfonyl Hydrazine Prodrugs). TAPET has been shown in preclinical models to effectively deliver anticancer agents while having a minimal toxic effect on healthy normal tissues. TAPET uses genetically altered strains of Salmo...Millennium and Wyeth-Ayerst announce the discovery of key potassium ion channel modulating proteins
...fic manner. This may allow for the development of therapeutics for CNS disorders that do not cause unwanted side effects in other non-brain tissues such as the heart. "We have found that KChIPs restore many important features of the physiological properties of native A-type potassium channels," said Frank An, ...ZymoGenetics discovers potential new therapy for autoimmune diseases
...gnize the powerful opportunity to identify protein therapeutics from genomics approaches," said ZymoGenetics President and CEO, Bruce L.A. Carter, Ph.D. "Our discovery that the soluble TACI receptor inhibits symptoms of autoimmune disease provides further validation of our strategy, which combines expertise in ......f. Their study has implications for the search for therapeutics in cases of MYC-induced breast cancer. MYC is an oncogene, a gene that has the potential to cause cells to grow out of control, resulting in tumor growth, said Lewis A. Chodosh, PhD, associate professor in the Department of Molecular and Cellular...